Louisville vs Ole Miss Prediction, Picks & Odds | 06 Sep 2026
College Football Betting Preview: Louisville vs Ole Miss
Louisville square off against Ole Miss at Vaught-Hemingway Stadium, with kickoff scheduled for 19:30 on Sunday, September 6.
We’re confident of backing Ole Miss to cover the -6.5 spread when they face Louisville. This is a generous line and the Rebels look a value bet at odds of -115.
Louisville Cardinals finished last season with a 27-22 win over Toledo Rockets in the Boca Raton Bowl at L&N Federal Credit Union Stadium.
Ole Miss Rebels enjoyed a deep postseason run last season, reaching the College Football Playoff semifinals before suffering a 31-27 loss to Miami Hurricanes at State Farm Stadium.
Head-to-Head Statistics
The last matchup between Ole Miss and Louisville saw the former win. It was a 43-24 scoreline at L&N Federal Credit Union Stadium.
Quarterbacks
Lincoln Kienholz
Trinidad Chambliss
Louisville vs Ole Miss Prediction & Picks
From our key match prediction to correct score pick, top player prop insights and a builder tailored for value — our Louisville vs Ole Miss betting tips covers it all.
Game Prediction
Back the moneyline favorites with a -6.5 spread in the college football matchup. This is a good number and we're confident Ole Miss can cover this appealing line at odds of -115.
We put solid research behind every CFB pick, starting with recent form and a clear read on injuries. From there, key stats and advanced metrics help complete the picture and support smarter betting decisions.
Key Louisville vs Ole Miss stats:
Ole Miss -6.5 Probability
The top sportsbooks are estimating that there is a 53.5% likelihood of this pick winning. In our opinion, there’s actually a probability of success closer to 60%. This is why we regard this as a value wager.
There are many betting alternatives to the spread and we particularly like the Winning Margin lines. It’s great whether you’re expecting things to be close or comprehensive.
Get more from your bet. Explore our updated guide featuring the hottest betting offers and best welcome bonus deals.
Player Prop Picks
Lincoln Kienholz (Louisville) is available at -114 to finish with fewer than 213.5 passing yards. He is likely to fall short of the line, making this QB Passing Yards bet an appealing option.
Kewan Lacy (Louisville) is available at -120 to finish with fewer than 16.5 receiving yards. He is likely to fall short of the line, making this Player Receiving Yards bet an appealing option.
Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.
Same Game Parlay Pick
Our same game parlay pick is Ole Miss -6.5 on the spread, Under 54.5 and Lincoln Kienholz (Louisville) to have Under 213.5 passing yards.
A football same game parlay is a single event wager where you make predictions that are going to happen in a particular game. Should a bettor get these picks correct, then they can achieve a big return from a small stake.
Correct Score Prediction
17
-
28
Ole Miss
There are some huge returns lying in wait if you can get the correct score right. With this in mind, we’ll have a play on the Rebels to enjoy a 28-17 winning scoreline.
Louisville vs Ole Miss Odds
The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.
With the sportsbooks giving them a 72% probability of winning this college game, Ole Miss might be a popular parlay pick. That is reflected in their -263 Moneyline betting odds. The market suggests that Louisville are least likely to win at +215.
The current spread is 6.5 and total points is 55.5. A Total bet relates to the number of points that will be scored overall. Those that want to back Under 55.5 can find odds of -115 available.
If you’re betting on college football, we recommend heading to the top betting apps and scanning through the many team props and game lines. There’s a chance to wager pre-game and in-game.
Kewan Lacy is the market leader at +360 to be the First TD Scorer. Should you think he will score the final touchdown, then a similar price can be found.
Touchdown
Receiving Yards
Rushing Yards
Passing Yards
Micro betting provides a rollercoaster ride for college football bettors. It can be great to enjoy the live lines, with the opportunity to wager on the Next Scoring Play. Watch the live action before deciding which way to go.
Can Ole Miss Continue Strong Home Form?
Ole Miss own a 10-0 mark in their past 10 home games, averaging 37.70 points scored and 15.40 points allowed.
Louisville own a 8-2 mark in their past 10 games on the road, posting 29.10 points per contest while yielding 25.60.
Ole Miss defeated Louisville 43-24 in their last meeting at Vaught-Hemingway Stadium.
| Last 10 Games | W-L | P | PF | PA | O54.5 | U54.5 | |
|---|---|---|---|---|---|---|---|
 Ole Miss Home Stats |
10-0 | 53.10 | 37.70 | 15.40 | 4 | 6 | |
 Louisville Away Stats |
8-2 | 54.70 | 29.10 | 25.60 | 5 | 5 | |
- W-L = Wins-Losses
- P = Avg. Points
- PF = Avg. Points For
- PA = Avg. Points Against
- O54.5 = Games Over 54.5 Points
- U54.5 = Games Under 54.5 Points
Latest regular season and playoff games stats.
Louisville Cardinals Stats
Ole Miss Stats
- 6 wins and 4 defeats in the last 10 games
- 8 wins and 2 defeats in the last 10 games on the road
- +6.5 Betting Line: Have covered the spread in 9 of the last 10 games
- +6.5 Betting Line on the Road: Have covered the spread in 9 of the last 10 games on the road
- -6.5 Betting Line: Have covered the spread in 6 of the last 10 games
- -6.5 Betting Line at Home: Have covered the spread in 6 of the last 10 home games
- Game Totals: An average of 49.70 pts in the previous 10 games
- Game Totals on the Road: An average of 54.70 pts in the previous 10 games on the road
- Over 54.5: Covered in 4 of the previous 10 games
- Over 54.5 on the Road: Covered in 5 of the previous 10 games on the road
- Team Totals: Have scored an average of 27.00 pts and allowed 22.70 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 29.10 pts and allowed 25.60 pts in the last 10 games on the road
- Game Totals: An average of 57.30 pts in the previous 10 games
- Game Totals at Home: An average of 54.90 pts in the previous 10 home games
- Over 54.5: Covered in 6 of the previous 10 games
- Over 54.5 at Home: Covered in 5 of the previous 10 home games
- Team Totals: Have scored an average of 35.10 pts and allowed 22.20 pts in the last 10 games
- Team Totals at Home: Have scored an average of 37.80 pts and allowed 17.10 pts in the last 10 home games
| Southeastern | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
Georgia
|
6 | 1 | 301 | 111 | 190 | 4-1 | 2-0 | 1L |
Kentucky
|
6 | 1 | 229 | 181 | 48 | 3-1 | 3-0 | 5W |
Tennessee
|
6 | 1 | 234 | 103 | 131 | 4-1 | 2-0 | 3W |
|
Ole Miss
|
5 | 1 | 225 | 143 | 82 | 4-0 | 1-1 | 2W |
Alabama
|
5 | 2 | 275 | 150 | 125 | 3-1 | 2-1 | 2L |
Florida
|
5 | 2 | 277 | 198 | 79 | 3-1 | 2-1 | 1W |
LSU
|
5 | 2 | 283 | 111 | 172 | 5-0 | 0-2 | 1W |
Missouri
|
5 | 2 | 218 | 137 | 81 | 4-0 | 1-2 | 1L |
Auburn
|
4 | 2 | 161 | 131 | 30 | 3-1 | 1-1 | 1W |
Mississippi State
|
4 | 2 | 195 | 171 | 24 | 2-1 | 2-1 | 2L |
Texas
|
4 | 2 | 181 | 107 | 74 | 3-1 | 1-1 | 2L |
Oklahoma
|
3 | 3 | 128 | 109 | 19 | 3-1 | 0-2 | 1L |
Texas A&M
|
4 | 3 | 206 | 120 | 86 | 4-1 | 0-2 | 1W |
South Carolina
|
3 | 3 | 226 | 153 | 73 | 2-2 | 1-1 | 1W |
Arkansas
|
3 | 4 | 147 | 187 | -40 | 2-2 | 1-2 | 1W |
Vanderbilt
|
3 | 4 | 165 | 208 | -43 | 3-2 | 0-2 | 4L |
| Atlantic Coast | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
Miami
|
6 | 0 | 291 | 84 | 207 | 3-0 | 3-0 | 6W |
Wake Forest
|
6 | 1 | 262 | 136 | 126 | 2-1 | 4-0 | 4W |
SMU
|
5 | 1 | 196 | 128 | 68 | 4-0 | 1-1 | 3W |
Clemson
|
4 | 2 | 134 | 129 | 5 | 3-1 | 1-1 | 1W |
North Carolina
|
4 | 2 | 141 | 115 | 26 | 1-1 | 3-1 | 2W |
|
Louisville
|
4 | 3 | 271 | 192 | 79 | 3-1 | 1-2 | 2W |
Duke
|
5 | 2 | 209 | 112 | 97 | 3-1 | 2-1 | 1W |
Pittsburgh
|
5 | 2 | 230 | 115 | 115 | 4-1 | 1-1 | 2L |
Virginia Tech
|
5 | 2 | 260 | 148 | 112 | 3-1 | 2-1 | 1W |
California
|
3 | 4 | 167 | 194 | -27 | 2-3 | 1-1 | 1L |
Stanford
|
4 | 4 | 159 | 284 | -125 | 4-1 | 0-3 | 2W |
Virginia
|
4 | 4 | 226 | 157 | 69 | 4-2 | 0-2 | 2L |
Boston College
|
3 | 3 | 122 | 138 | -16 | 3-1 | 0-2 | 1W |
Georgia Tech
|
2 | 4 | 160 | 163 | -3 | 2-2 | 0-2 | 1L |
Florida State
|
3 | 4 | 221 | 195 | 26 | 3-1 | 0-3 | 2L |
NC State
|
3 | 4 | 226 | 197 | 29 | 3-1 | 0-3 | 2L |
Syracuse
|
2 | 4 | 190 | 154 | 36 | 1-2 | 1-2 | 2L |
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