Louisville vs Ole Miss Prediction, Picks & Odds | 06 Sep 2026

College Football Betting Preview: Louisville vs Ole Miss

Louisville square off against Ole Miss at Vaught-Hemingway Stadium, with kickoff scheduled for 19:30 on Sunday, September 6.

We’re confident of backing Ole Miss to cover the -6.5 spread when they face Louisville. This is a generous line and the Rebels look a value bet at odds of -115.

Louisville Cardinals finished last season with a 27-22 win over Toledo Rockets in the Boca Raton Bowl at L&N Federal Credit Union Stadium.

Ole Miss Rebels enjoyed a deep postseason run last season, reaching the College Football Playoff semifinals before suffering a 31-27 loss to Miami Hurricanes at State Farm Stadium.

Head-to-Head Statistics

The last matchup between Ole Miss and Louisville saw the former win. It was a 43-24 scoreline at L&N Federal Credit Union Stadium.

Quarterbacks

Lincoln Kienholz

205.5 Passing Yards

Over -112

Under -112

Trinidad Chambliss

272.5 Passing Yards

Over -112

Under -112

Louisville vs Ole Miss Prediction & Picks

From our key match prediction to correct score pick, top player prop insights and a builder tailored for value — our Louisville vs Ole Miss betting tips covers it all.

Game Prediction

Back the moneyline favorites with a -6.5 spread in the college football matchup. This is a good number and we're confident Ole Miss can cover this appealing line at odds of -115.

We put solid research behind every CFB pick, starting with recent form and a clear read on injuries. From there, key stats and advanced metrics help complete the picture and support smarter betting decisions.

Key Louisville vs Ole Miss stats:

• The -6.5 line has been covered by Ole Miss in 4 of their last 5 games at home.
• The -6.5 line has been covered by Ole Miss in 14 of their last 20 games at home.

Ole Miss -6.5 Probability

The top sportsbooks are estimating that there is a 53.5% likelihood of this pick winning. In our opinion, there’s actually a probability of success closer to 60%. This is why we regard this as a value wager.

There are many betting alternatives to the spread and we particularly like the Winning Margin lines. It’s great whether you’re expecting things to be close or comprehensive.

Get more from your bet. Explore our updated guide featuring the hottest betting offers and best welcome bonus deals.

Our Game Prediction

Ole Miss -6.5 @ -115 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Sep 5, 02:25). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Lincoln Kienholz Under 213.5 Passing Yards -114

Lincoln Kienholz (Louisville) is available at -114 to finish with fewer than 213.5 passing yards. He is likely to fall short of the line, making this QB Passing Yards bet an appealing option.

Latest Lincoln Kienholz Player Prop Odds

Touchdown

Anytime

+210

First

+1700

Passing Yards

Over 205.5

-112

Under 205.5

-112

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Kewan Lacy Under 16.5 Receiving Yards -120

Kewan Lacy (Louisville) is available at -120 to finish with fewer than 16.5 receiving yards. He is likely to fall short of the line, making this Player Receiving Yards bet an appealing option.

Latest Kewan Lacy Player Prop Odds

Touchdown

Anytime

-222

First

+360

Receiving Yards

Over 14.5

-112

Under 14.5

-112

Rushing Yards

Over 90.5

-112

Under 90.5

-112

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Louisville 17 - 28 Ole Miss

There are some huge returns lying in wait if you can get the correct score right. With this in mind, we’ll have a play on the Rebels to enjoy a 28-17 winning scoreline.

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Louisville vs Ole Miss Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

With the sportsbooks giving them a 72% probability of winning this college game, Ole Miss might be a popular parlay pick. That is reflected in their -263 Moneyline betting odds. The market suggests that Louisville are least likely to win at +215.

The current spread is 6.5 and total points is 55.5. A Total bet relates to the number of points that will be scored overall. Those that want to back Under 55.5 can find odds of -115 available.

If you’re betting on college football, we recommend heading to the top betting apps and scanning through the many team props and game lines. There’s a chance to wager pre-game and in-game.

Moneyline

Louisville

+215

Ole Miss

-263

Point Spread

Louisville +6.5

-104

Ole Miss -6.5

-118

Total Points

Under 55.5

-115

Over 55.5

-105

Kewan Lacy is the market leader at +360 to be the First TD Scorer. Should you think he will score the final touchdown, then a similar price can be found.

Touchdown

Kewan Lacy (Ole Miss)

First TD

+360

Anytime TD

-222

Isaac Brown (Louisville)

First TD

+700

Anytime TD

-110

Trinidad Chambliss (Ole Miss)

First TD

+800

Anytime TD

-110

Deuce Alexander (Ole Miss)

First TD

+1000

Anytime TD

+145

Darrell Gill jr. (Ole Miss)

First TD

+1100

Anytime TD

+180

Keyjuan Brown (Louisville)

First TD

+1200

Anytime TD

+150

Lincoln Kienholz (Louisville)

First TD

+1700

Anytime TD

+210

Tre Richardson (Louisville)

First TD

+1700

Anytime TD

+210

Johntay Cook II (Ole Miss)

First TD

+1800

Anytime TD

+290

Makhi Frazier (Ole Miss)

First TD

+2000

Anytime TD

+250

Lawayne McCoy (Louisville)

First TD

+2000

Anytime TD

+260

TreyShun Hurry (Louisville)

First TD

+2200

Anytime TD

+310

Luke Hasz (Ole Miss)

First TD

+2200

Anytime TD

+380

Brody Foley (Louisville)

First TD

+2500

Anytime TD

+310

Caleb Odom (Ole Miss)

First TD

+2700

Anytime TD

+480

Jackson Voth (Louisville)

First TD

+3000

Anytime TD

+470

Caleb Cunningham (Ole Miss)

First TD

+3000

Anytime TD

+500

Receiving Yards

Deuce Alexander (Ole Miss)

Over 57.5

-112

Under 57.5

-112

Tre Richardson (Louisville)

Over 52.5

-112

Under 52.5

-112

Johntay Cook II (Ole Miss)

Over 40.5

-112

Under 40.5

-112

Luke Hasz (Ole Miss)

Over 30.5

-112

Under 30.5

-112

TreyShun Hurry (Louisville)

Over 29.5

-112

Under 29.5

-112

Kewan Lacy (Ole Miss)

Over 14.5

-112

Under 14.5

-112

Rushing Yards

Kewan Lacy (Ole Miss)

Over 90.5

-112

Under 90.5

-112

Isaac Brown (Louisville)

Over 67.5

-112

Under 67.5

-112

Trinidad Chambliss (Ole Miss)

Over 27.5

-112

Under 27.5

-112

Passing Yards

Trinidad Chambliss (Ole Miss)

Over 272.5

-112

Under 272.5

-112

Lincoln Kienholz (Louisville)

Over 205.5

-112

Under 205.5

-112

Micro betting provides a rollercoaster ride for college football bettors. It can be great to enjoy the live lines, with the opportunity to wager on the Next Scoring Play. Watch the live action before deciding which way to go.

Can Ole Miss Continue Strong Home Form?

Ole Miss own a 10-0 mark in their past 10 home games, averaging 37.70 points scored and 15.40 points allowed.

Louisville own a 8-2 mark in their past 10 games on the road, posting 29.10 points per contest while yielding 25.60.

Ole Miss defeated Louisville 43-24 in their last meeting at Vaught-Hemingway Stadium.

Last 10 Games		W-L	P	PF	PA	O54.5	U54.5
Ole Miss Home Stats		10-0	53.10	37.70	15.40	4	6
Louisville Away Stats		8-2	54.70	29.10	25.60	5	5

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O54.5 = Games Over 54.5 Points
• U54.5 = Games Under 54.5 Points

Latest regular season and playoff games stats.

Louisville Cardinals Stats

Ole Miss Stats

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 8 wins and 2 defeats in the last 10 games on the road

Moneyline

• 8 wins and 2 defeats in the last 10 games
• 9 wins and 1 defeat in the last 10 home games

Point Spread

• +6.5 Betting Line: Have covered the spread in 9 of the last 10 games
• +6.5 Betting Line on the Road: Have covered the spread in 9 of the last 10 games on the road

Point Spread

• -6.5 Betting Line: Have covered the spread in 6 of the last 10 games
• -6.5 Betting Line at Home: Have covered the spread in 6 of the last 10 home games

Total Points

• Game Totals: An average of 49.70 pts in the previous 10 games
• Game Totals on the Road: An average of 54.70 pts in the previous 10 games on the road
• Over 54.5: Covered in 4 of the previous 10 games
• Over 54.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 27.00 pts and allowed 22.70 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 29.10 pts and allowed 25.60 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 57.30 pts in the previous 10 games
• Game Totals at Home: An average of 54.90 pts in the previous 10 home games
• Over 54.5: Covered in 6 of the previous 10 games
• Over 54.5 at Home: Covered in 5 of the previous 10 home games
• Team Totals: Have scored an average of 35.10 pts and allowed 22.20 pts in the last 10 games
• Team Totals at Home: Have scored an average of 37.80 pts and allowed 17.10 pts in the last 10 home games

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