Chiefs vs Giants Prediction, Picks & Odds | 21 Sep 2025

NFL Betting Preview: Chiefs vs Giants

The Kansas City Chiefs battle the New York Giants in this NFL Week 3 matchup at MetLife Stadium, with kickoff scheduled for 20:20 on Sunday, September 21. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

The Giants should be able to battle hard and our prediction is that they will cover the spread against the Chiefs. It’s set at an attractive +5.5 and you can get -102.

Kansas City Chiefs suffered a second consecutive defeat when losing 20-17 in their previous game. This was at home to Philadelphia Eagles at GEHA Field at Arrowhead Stadium. The Chiefs generated 294 yards, including 173 passing and 121 rushing yards. The offense picked up 17 first downs and scored 2 touchdowns. One passing and one rushing TD.

New York Giants have been defeated in back-to-back games. On the road, they recently suffered a 40-37 (OT) loss against Dallas Cowboys at AT&T Stadium. The Giants totaled 506 yards, with 422 through the air and 84 on the ground. The offense converted for 22 first downs along with 4 touchdowns.

Head-to-Head Statistics

It was the Chiefs who came out on top when they last played the Giants. At GEHA Field at Arrowhead Stadium, a 20-17 win was recorded.

Quarterbacks

Patrick Mahomes

234.5 Passing Yards

Over -112

Under -112

Russell Wilson

224.5 Passing Yards

Over -112

Under -112

Chiefs vs Giants Prediction & Picks

Our Chiefs vs Giants betting guide delivers expert insight, including a main match pick, scoreline advice, standout player props and bet builder recommendations. Dive into each section below for more.

Game Prediction

We’re really sweet on the Giants putting up a fight in this NFL showdown and that compels us to bet the underdogs against the spread. You can get -102 when it comes to the +5.5 that is available.

We use the latest team news and injury updates to help shape the best possible NFL picks. You’ll also notice we take a stats-led approach by factoring in the key numbers that truly make a difference.

Key Chiefs vs Giants stats:

• The +5.5 line has been covered by Giants in 12 of their last 20 games at home.
• The +5.5 line has been covered by Giants in 3 of their last 5 games at home.
• The -5.5 line hasn’t been covered by Chiefs in 4 consecutive games.
• The -5.5 line hasn’t been covered by Chiefs in 6 of their last 10 games.
• The -5.5 line hasn’t been covered by Chiefs in 11 of their last 20 games.

Giants +5.5 Probability

The top NFL sportsbooks make it a 50.5% chance that our pick is settled as a winner. Our cappers think there’s a stronger chance of success and calculate the probability to be closer to 60%. It is therefore regarded as a value bet.

Looking for more juice from your spread pick? By moving the betting line, you are able to get bigger odds although you will need to take a riskier wager.

Getting ready to place a wager? Check our updated guide for the latest betting offers, including free bets and the newest promos codes.

Our Game Prediction

Giants +5.5 @ -102 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Sep 20, 02:26). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Russell Wilson Over 226.5 Passing Yards -114

Russell Wilson (Giants) is available at -114 to exceed 226.5 passing yards. He looks capable of covering the line and that leads us to taking this QB Passing Yards bet.

Latest Russell Wilson Player Prop Odds

Touchdown

Anytime

+700

First

+3000

Passing Yards

Over 224.5

-112

Under 224.5

-112

Rushing Yards

Over 19.5

-112

Under 19.5

-112

---

Tyrone Tracy Jr. Over 30.5 Rushing Yards -114

Tyrone Tracy Jr. (Giants) can be backed at -114 to surpass 30.5 rushing yards. The line for him on the Overs looks attractive and bettors can get plenty of juice from this Player Rushing Yards wager.

Latest Tyrone Tracy Jr. Player Prop Odds

Touchdown

Anytime

+310

First

+1800

Receiving Yards

Over 13.5

-112

Under 13.5

-112

Rushing Yards

Over 21.5

-112

Under 21.5

-112

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Chiefs 24 - 23 Giants

Don’t pass up the opportunity to have a speculative wager on the Chiefs to claim a 24-23 victory. We don’t think that there will be too much between the teams.

T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Chiefs vs Giants Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

With the sportsbooks giving them a 76% probability of winning this game, Kansas City Chiefs might be a popular parlay pick. That is reflected in their -323 Moneyline betting odds. For those wanting to oppose the market leader, you can get +260 about New York Giants.

The spread is 5.5 and the total points line is currently 44.5. A bet on the Totals allows fans to use the latest NFL data to good effect. Those who wager Under 44.5 can get -110.

There are hundreds of team props and game lines when it comes to wagering on the National Football League and we recommend visiting the best sportsbooks to find the bet that matches your view on the game.

Moneyline

Chiefs

-323

Giants

+260

Point Spread

Chiefs -5.5

-120

Giants +5.5

-102

Total Points

Under 44.5

-110

Over 44.5

-110

Marquise Brown can be backed to score a TD at any stage at +130. There is the opportunity to back the market leader to grab the first touchdown at +650.

Touchdown

Marquise Brown (Chiefs)

First TD

+650

Anytime TD

+130

Travis Kelce (Chiefs)

First TD

+700

Anytime TD

+135

Malik Nabers (Giants)

First TD

+800

Anytime TD

+135

Xavier Worthy (Chiefs)

First TD

+800

Anytime TD

+160

Isiah Pacheco (Chiefs)

First TD

+900

Anytime TD

+190

Cam Skattebo (Giants)

First TD

+900

Anytime TD

+175

Kareem Hunt (Chiefs)

First TD

+1200

Anytime TD

+210

JuJu Smith-Schuster (Chiefs)

First TD

+1300

Anytime TD

+260

Tyquan Thornton (Chiefs)

First TD

+1500

Anytime TD

+320

Wan'Dale Robinson (Giants)

First TD

+1500

Anytime TD

+290

Patrick Mahomes (Chiefs)

First TD

+1600

Anytime TD

+360

Tyrone Tracy Jr. (Giants)

First TD

+1800

Anytime TD

+310

Darius Slayton (Giants)

First TD

+2200

Anytime TD

+450

Theo Johnson (Giants)

First TD

+2200

Anytime TD

+410

Noah Gray (Chiefs)

First TD

+2200

Anytime TD

+470

Russell Wilson (Giants)

First TD

+3000

Anytime TD

+700

Devin Singletary (Giants)

First TD

+7500

Anytime TD

+1600

Jalen Royals (Chiefs)

First TD

+8000

Anytime TD

+1700

Brashard Smith (Chiefs)

First TD

+8000

Anytime TD

+1900

Daniel Bellinger (Giants)

First TD

+8000

Anytime TD

+2000

Beaux Collins (Giants)

First TD

+8000

Anytime TD

+1700

Jason Brownlee (Chiefs)

First TD

+10000

Anytime TD

+1700

Elijah Mitchell (Chiefs)

First TD

+10000

Anytime TD

+1700

Jalin Hyatt (Giants)

First TD

+10000

Anytime TD

+3500

Nikko Remigio (Chiefs)

First TD

+10000

Anytime TD

+2700

Robert Tonyan (Chiefs)

First TD

+10000

Anytime TD

+3000

Jared Wiley (Chiefs)

First TD

+10000

Anytime TD

+1800

Gunner Olszewski (Giants)

First TD

+10000

Anytime TD

+3500

Chris Manhertz (Giants)

First TD

+10000

Anytime TD

+4500

Thomas Fidone (Giants)

First TD

+10000

Anytime TD

+3000

Receiving Yards

Malik Nabers (Giants)

Over 79.5

-112

Under 79.5

-112

Marquise Brown (Chiefs)

Over 54.5

-112

Under 54.5

-112

Travis Kelce (Chiefs)

Over 48.5

-112

Under 48.5

-112

Wan'Dale Robinson (Giants)

Over 45.5

-112

Under 45.5

-112

JuJu Smith-Schuster (Chiefs)

Over 30.5

-112

Under 30.5

-112

Tyquan Thornton (Chiefs)

Over 29.5

-112

Under 29.5

-112

Theo Johnson (Giants)

Over 22.5

-112

Under 22.5

-112

Darius Slayton (Giants)

Over 20.5

-112

Under 20.5

-112

Noah Gray (Chiefs)

Over 14.5

-112

Under 14.5

-112

Tyrone Tracy Jr. (Giants)

Over 13.5

-112

Under 13.5

-112

Cam Skattebo (Giants)

Over 11.5

-112

Under 11.5

-112

Isiah Pacheco (Chiefs)

Over 8.5

-118

Under 8.5

-108

Kareem Hunt (Chiefs)

Over 7.5

-112

Under 7.5

-112

Rushing Yards

Isiah Pacheco (Chiefs)

Over 41.5

-112

Under 41.5

-112

Cam Skattebo (Giants)

Over 37.5

-112

Under 37.5

-112

Kareem Hunt (Chiefs)

Over 29.5

-112

Under 29.5

-112

Patrick Mahomes (Chiefs)

Over 28.5

-112

Under 28.5

-112

Tyrone Tracy Jr. (Giants)

Over 21.5

-112

Under 21.5

-112

Russell Wilson (Giants)

Over 19.5

-112

Under 19.5

-112

Passing Yards

Patrick Mahomes (Chiefs)

Over 234.5

-112

Under 234.5

-112

Russell Wilson (Giants)

Over 224.5

-112

Under 224.5

-112

An increasing number of bettors are now enjoying micro betting on the NFL and it’s something which is available on an in-game basis. Wait for the action to start and then wager on something specific to happen.

Giants Home Record Reads Eight Defeats From Last Ten

The Giants are 2-8 in their last 10 home games, putting up 15.70 points on average and giving up 24.20.

The Chiefs have been beaten three consecutive times away from home. They have a 6-4 record in their last 10 road games, scoring 21.60 points per contest and conceding 22.70.

Last 10 Games		W-L	P	PF	PA	O44.5	U44.5
Giants Home Stats		2-8	39.90	15.70	24.20	3	7
Chiefs Away Stats		6-4	44.30	21.60	22.70	6	4

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O44.5 = Games Over 44.5 Points
• U44.5 = Games Under 44.5 Points

Latest regular season and playoff games stats.

Kansas City Chiefs Stats

New York Giants Stats

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 6 wins and 4 defeats in the last 10 games on the road

Moneyline

• 1 win and 9 defeats in the last 10 games
• 2 wins and 8 defeats in the last 10 home games

Point Spread

• -5.5 Betting Line: Have covered the spread in 4 of the last 10 games
• -5.5 Betting Line on the Road: Have covered the spread in 5 of the last 10 games on the road

Point Spread

• +5.5 Betting Line: Have covered the spread in 4 of the last 10 games
• +5.5 Betting Line at Home: Have covered the spread in 5 of the last 10 home games

Total Points

• Game Totals: An average of 43.20 pts in the previous 10 games
• Game Totals on the Road: An average of 44.30 pts in the previous 10 games on the road
• Over 44.5: Covered in 4 of the previous 10 games
• Over 44.5 on the Road: Covered in 6 of the previous 10 games on the road
• Team Totals: Have scored an average of 21.10 pts and allowed 22.10 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 21.60 pts and allowed 22.70 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 45.10 pts in the previous 10 games
• Game Totals at Home: An average of 39.90 pts in the previous 10 home games
• Over 44.5: Covered in 4 of the previous 10 games
• Over 44.5 at Home: Covered in 3 of the previous 10 home games
• Team Totals: Have scored an average of 17.70 pts and allowed 27.40 pts in the last 10 games
• Team Totals at Home: Have scored an average of 15.70 pts and allowed 24.20 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 296.70 Yds. Allowed 337.30 Yds
• Rushing Yards: Gained 90.10 Yds. Allowed 132.00 Yds
• Passing Yards: Gained 206.60 Yds. Allowed 205.30 Yds
• Total Touchdowns: Scored 2.40 TD. Allowed 2.50 TD
• Rushing Touchdowns: Scored 1.00 TD. Allowed 1.00 TD
• Passing Touchdowns: Scored 1.40 TD. Allowed 1.40 TD
• Total 1st Downs: Picked up 17.70. Allowed 20.70
• Total Turnovers: Committed 0.50. Committed by opponents 1.10
• Total Penalties: Committed 5.80. Committed by opponents 6.20
• Penalty Yards: Lost 49.40 Yds. Gained 49.20 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 299.30 Yds. Allowed 379.80 Yds
• Rushing Yards: Gained 90.90 Yds. Allowed 138.70 Yds
• Passing Yards: Gained 208.40 Yds. Allowed 241.10 Yds
• Total Touchdowns: Scored 2.00 TD. Allowed 3.30 TD
• Rushing Touchdowns: Scored 0.90 TD. Allowed 1.50 TD
• Passing Touchdowns: Scored 1.00 TD. Allowed 1.50 TD
• Total 1st Downs: Picked up 17.20. Allowed 22.80
• Total Turnovers: Committed 1.30. Committed by opponents 0.90
• Total Penalties: Committed 8.10. Committed by opponents 6.90
• Penalty Yards: Lost 72.50 Yds. Gained 56.20 Yds

Last 10 Games on the Road

• Total Yards: Gained 306.20 Yds. Allowed 331.00 Yds
• Rushing Yards: Gained 98.50 Yds. Allowed 110.20 Yds
• Passing Yards: Gained 207.70 Yds. Allowed 220.80 Yds
• Total Touchdowns: Scored 2.70 TD. Allowed 2.50 TD
• Rushing Touchdowns: Scored 0.90 TD. Allowed 1.00 TD
• Passing Touchdowns: Scored 1.80 TD. Allowed 1.40 TD
• Total 1st Downs: Picked up 18.00. Allowed 20.20
• Total Turnovers: Committed 1.00. Committed by opponents 1.40
• Total Penalties: Committed 6.60. Committed by opponents 6.10
• Penalty Yards: Lost 57.20 Yds. Gained 41.90 Yds

Last 10 Home Games

• Total Yards: Gained 290.70 Yds. Allowed 353.80 Yds
• Rushing Yards: Gained 89.10 Yds. Allowed 140.80 Yds
• Passing Yards: Gained 201.60 Yds. Allowed 213.00 Yds
• Total Touchdowns: Scored 1.80 TD. Allowed 3.10 TD
• Rushing Touchdowns: Scored 0.80 TD. Allowed 1.40 TD
• Passing Touchdowns: Scored 0.80 TD. Allowed 1.60 TD
• Total 1st Downs: Picked up 17.80. Allowed 19.60
• Total Turnovers: Committed 0.90. Committed by opponents 1.30
• Total Penalties: Committed 5.60. Committed by opponents 6.20
• Penalty Yards: Lost 53.80 Yds. Gained 51.80 Yds

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