49ers vs Rams Prediction, Picks & Odds | 10 Sep 2026

NFL Betting Preview: Niners vs Rams

The San Francisco 49ers battle the Los Angeles Rams at Melbourne Cricket Ground, with kickoff scheduled for 20:35 on Thursday, September 10.

Over 48.5 points are expected to be scored when the Rams and the Niners meet, with this prediction available at -105 and this looks like a value wager.

San Francisco 49ers were defeated in their previous game. On the road, they suffered a 41-6 reverse against Seattle Seahawks at Lumen Field. The 49ers finished with 236 yards, including 128 passing and 108 rushing yards. They allowed 19 first downs and produced 15.

Los Angeles Rams were beaten last game and this was on the road at Lumen Field. Seattle Seahawks claimed a 31-27 win. The Rams totaled 479 yards, with 365 through the air and 114 on the ground. The offense produced 26 first downs to go with 3 trips to the end zone.

Head-to-Head Statistics

It was a 42-26 win for the Rams at Levi's Stadium when they last played the Niners. The previous 10 games have seen both teams achieve five victories.

Quarterbacks

Brock Purdy

243.5 Passing Yards

Over -114

Under -114

Matthew Stafford

263.5 Passing Yards

Over -114

Under -114

49ers vs Rams Prediction & Picks

Get set for 49ers vs Rams with our full betting breakdown, complete with an expert match prediction, a likely final score, top player prop picks and a value-driven bet builder.

Game Prediction

We’re heading to the totals after finding that the line is set at a generous 48.5 points. Expect this number to be surpassed at -105 for this NFL battle.

Team news and current form always play a key role in shaping our expert NFL picks. We also dig into the latest stats and trends to help deliver the most accurate predictions possible.

Key 49ers vs Rams stats:

• The 48.5 line has been covered in 8 of the last 10 Rams games.
• The 48.5 line has been covered in 4 of the last 5 Rams games.
• The 48.5 line has been covered in the last 2 games between these teams.

Over 48.5 Probability

According to the latest betting odds, our pick has a 51.3% chance of winning. However, our analysts think that the probability is close to 60% taking all factors into consideration. This wager can therefore be backed with confidence.

There are ways to get bigger odds by betting Over on the Totals. Bettors often look to move the line so they can land a more profitable return if the selection wins.

Boost your betting strategy with exclusive offers, free bets, and welcome bonuses—all in our straightforward guide.

Our Game Prediction

Over 48.5 Points @ -105 Watch Live Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Sep 9, 03:25). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Kyren Williams Anytime TD -141

You can place a bet on Kyren Williams (Rams) to record a TD at -141. The Anytime Touchdown Scorer odds look attractive based on the evidence, and we’ll back him to take it to the house.

Latest Kyren Williams Player Prop Odds

Touchdown

Anytime

-141

First

+500

Receiving Yards

Over 10.5

-114

Under 10.5

-114

Rushing Yards

Over 55.5

-114

Under 55.5

-114

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Brock Purdy Over 243.5 Passing Yards -114

The odds for Brock Purdy (Niners) to rack up over 243.5 passing yards are -114. There’s an opportunity to place a QB Passing Yards bet, with him capable of covering an appealing line.

Latest Brock Purdy Player Prop Odds

Touchdown

Anytime

+550

First

+2700

Passing Yards

Over 243.5

-114

Under 243.5

-114

Rushing Yards

Over 17.5

-114

Under 17.5

-114

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

49ers 23 - 31 Rams

The Rams are capable of landing a victory and we’re going for a correct score line of 31-23 at huge odds. There’s a big return that can be achieved with this wager.

T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

49ers vs Rams Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

The Los Angeles Rams odds have been priced up by the sportsbooks and they are -204 betting favorites to land victory in this game which means a 67% chance of winning. San Francisco 49ers are trading at bigger odds than their opponents and they can be backed at +172.

The spread is 3.5 and the total points line is currently 48.5. NFL bettors love the chance to get an alternative angle by going for a Total wager. If you fancy Over 48.5, this outcome can be backed at -105.

If you’re betting on the National Football League, we recommend visiting the top betting apps and scanning through the many team props and game lines. There’s the opportunity to wager pre-game and in-game.

Moneyline

49ers

+172

Rams

-204

Point Spread

49ers +3.5

-102

Rams -3.5

-120

Total Points

Under 48.5

-115

Over 48.5

-105

The First Touchdown Scorer favorite is Kyren Williams at +500. Similar odds can be found if you’re interested in this player to register the final TD.

Touchdown

Kyren Williams (Rams)

First TD

+500

Anytime TD

-141

Christian McCaffrey (49ers)

First TD

+500

Anytime TD

-145

Puka Nacua (Rams)

First TD

+800

Anytime TD

+125

Davante Adams (Rams)

First TD

+800

Anytime TD

+120

Blake Corum (Rams)

First TD

+950

Anytime TD

+155

Mike Evans (49ers)

First TD

+1400

Anytime TD

+210

George Kittle (49ers)

First TD

+1500

Anytime TD

+290

Colby Parkinson (Rams)

First TD

+2000

Anytime TD

+400

Terrance Ferguson (Rams)

First TD

+2000

Anytime TD

+400

Deebo Samuel (49ers)

First TD

+2200

Anytime TD

+340

Brock Purdy (49ers)

First TD

+2700

Anytime TD

+550

Tyler Higbee (Rams)

First TD

+2700

Anytime TD

+550

Jordan Whittington (Rams)

First TD

+3500

Anytime TD

+900

Demarcus Robinson (49ers)

First TD

+4000

Anytime TD

+800

Kyle Juszczyk (49ers)

First TD

+4000

Anytime TD

+850

Jake Tonges (49ers)

First TD

+4500

Anytime TD

+600

Konata Mumpfield (Rams)

First TD

+5500

Anytime TD

+1300

CJ Daniels (Rams)

First TD

+5500

Anytime TD

+1300

Davis Allen (Rams)

First TD

+6000

Anytime TD

+1300

Max Klare (Rams)

First TD

+6000

Anytime TD

+1300

Kaelon Black (49ers)

First TD

+6500

Anytime TD

+950

James Jordan (49ers)

First TD

+6500

Anytime TD

+950

Matthew Stafford (Rams)

First TD

+10000

Anytime TD

+2200

Ronnie Rivers (Rams)

First TD

+10000

Anytime TD

+3500

Receiving Yards

Puka Nacua (Rams)

Over 90.5

-114

Under 90.5

-114

Davante Adams (Rams)

Over 51.5

-114

Under 51.5

-114

Mike Evans (49ers)

Over 49.5

-114

Under 49.5

-114

Christian McCaffrey (49ers)

Over 38.5

-114

Under 38.5

-114

George Kittle (49ers)

Over 36.5

-114

Under 36.5

-114

Deebo Samuel (49ers)

Over 29.5

-114

Under 29.5

-114

Terrance Ferguson (Rams)

Over 23.5

-114

Under 23.5

-114

Colby Parkinson (Rams)

Over 21.5

-114

Under 21.5

-114

Tyler Higbee (Rams)

Over 14.5

-114

Under 14.5

-114

Demarcus Robinson (49ers)

Over 11.5

-114

Under 11.5

-114

Kyren Williams (Rams)

Over 10.5

-114

Under 10.5

-114

Kyle Juszczyk (49ers)

Over 5.5

-114

Under 5.5

-114

Rushing Yards

Christian McCaffrey (49ers)

Over 59.5

-114

Under 59.5

-114

Kyren Williams (Rams)

Over 55.5

-114

Under 55.5

-114

Blake Corum (Rams)

Over 44.5

-114

Under 44.5

-114

Brock Purdy (49ers)

Over 17.5

-114

Under 17.5

-114

Puka Nacua (Rams)

Over 2.5

+102

Under 2.5

-132

Matthew Stafford (Rams)

Over 0.5

+136

Under 0.5

-179

Passing Yards

Matthew Stafford (Rams)

Over 263.5

-114

Under 263.5

-114

Brock Purdy (49ers)

Over 243.5

-114

Under 243.5

-114

Latest regular season and playoff games stats.

San Francisco 49ers Stats

Los Angeles Rams Stats

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 7 wins and 3 defeats in the last 10 games on the road

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 8 wins and 2 defeats in the last 10 home games

Point Spread

• +3.5 Betting Line: Have covered the spread in 7 of the last 10 games
• +3.5 Betting Line on the Road: Have covered the spread in 7 of the last 10 games on the road

Point Spread

• -3.5 Betting Line: Have covered the spread in 4 of the last 10 games
• -3.5 Betting Line at Home: Have covered the spread in 7 of the last 10 home games

Total Points

• Game Totals: An average of 51.50 pts in the previous 10 games
• Game Totals on the Road: An average of 50.50 pts in the previous 10 games on the road
• Over 48.5: Covered in 5 of the previous 10 games
• Over 48.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 27.20 pts and allowed 24.30 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 26.40 pts and allowed 24.10 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 58.00 pts in the previous 10 games
• Game Totals at Home: An average of 46.70 pts in the previous 10 home games
• Over 48.5: Covered in 8 of the previous 10 games
• Over 48.5 at Home: Covered in 4 of the previous 10 home games
• Team Totals: Have scored an average of 32.70 pts and allowed 25.30 pts in the last 10 games
• Team Totals at Home: Have scored an average of 28.30 pts and allowed 18.40 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 339.60 Yds. Allowed 337.90 Yds
• Rushing Yards: Gained 112.00 Yds. Allowed 116.80 Yds
• Passing Yards: Gained 227.60 Yds. Allowed 221.10 Yds
• Total Touchdowns: Scored 3.30 TD. Allowed 3.00 TD
• Rushing Touchdowns: Scored 1.00 TD. Allowed 1.20 TD
• Passing Touchdowns: Scored 2.20 TD. Allowed 1.60 TD
• Total 1st Downs: Picked up 22.10. Allowed 20.60
• Total Turnovers: Committed 1.40. Committed by opponents 0.90
• Total Penalties: Committed 3.30. Committed by opponents 5.90
• Penalty Yards: Lost 28.00 Yds. Gained 40.40 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 433.00 Yds. Allowed 348.40 Yds
• Rushing Yards: Gained 135.30 Yds. Allowed 119.50 Yds
• Passing Yards: Gained 297.70 Yds. Allowed 228.90 Yds
• Total Touchdowns: Scored 3.90 TD. Allowed 3.10 TD
• Rushing Touchdowns: Scored 1.20 TD. Allowed 0.70 TD
• Passing Touchdowns: Scored 2.20 TD. Allowed 1.70 TD
• Total 1st Downs: Picked up 23.80. Allowed 19.10
• Total Turnovers: Committed 0.90. Committed by opponents 1.30
• Total Penalties: Committed 4.20. Committed by opponents 5.10
• Penalty Yards: Lost 30.20 Yds. Gained 38.30 Yds

Last 10 Games on the Road

• Total Yards: Gained 328.10 Yds. Allowed 352.10 Yds
• Rushing Yards: Gained 93.30 Yds. Allowed 112.50 Yds
• Passing Yards: Gained 234.80 Yds. Allowed 239.60 Yds
• Total Touchdowns: Scored 2.90 TD. Allowed 2.90 TD
• Rushing Touchdowns: Scored 0.70 TD. Allowed 0.90 TD
• Passing Touchdowns: Scored 2.10 TD. Allowed 1.90 TD
• Total 1st Downs: Picked up 20.90. Allowed 20.50
• Total Turnovers: Committed 1.10. Committed by opponents 1.10
• Total Penalties: Committed 4.20. Committed by opponents 6.60
• Penalty Yards: Lost 32.60 Yds. Gained 44.30 Yds

Last 10 Home Games

• Total Yards: Gained 384.30 Yds. Allowed 315.40 Yds
• Rushing Yards: Gained 108.80 Yds. Allowed 96.90 Yds
• Passing Yards: Gained 275.50 Yds. Allowed 218.50 Yds
• Total Touchdowns: Scored 3.40 TD. Allowed 1.80 TD
• Rushing Touchdowns: Scored 0.60 TD. Allowed 0.30 TD
• Passing Touchdowns: Scored 2.60 TD. Allowed 1.50 TD
• Total 1st Downs: Picked up 22.20. Allowed 18.80
• Total Turnovers: Committed 0.70. Committed by opponents 1.70
• Total Penalties: Committed 5.00. Committed by opponents 5.80
• Penalty Yards: Lost 39.90 Yds. Gained 41.50 Yds

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