49ers vs Rams Prediction, Picks & Odds | 10 Sep 2026

NFL Betting Preview: Niners vs Rams

The San Francisco 49ers battle the Los Angeles Rams at Melbourne Cricket Ground in Australia for the first international game of the NFL season, with kickoff scheduled for 20:35 on Thursday, September 10. The matchup will be broadcast live on Netflix.

Over 48.5 points are expected to be scored when the Rams and the Niners meet, with this prediction available at -105 and this looks like a value wager.

San Francisco 49ers finished last season with a 12-5 regular-season record before reaching the NFC Divisional Round. Their campaign ended with a 41-6 road loss to the Seattle Seahawks at Lumen Field, with Seattle later going on to win the Super Bowl. The Niners finished with 236 yards, including 128 passing and 108 rushing yards. They allowed 19 first downs and produced 15.

Los Angeles Rams also went 12-5 during the regular season but advanced one round further in the playoffs. They were also eliminated by the Seahawks, suffering a 31-27 road loss at Lumen Field in the NFC Championship Game. The Rams totaled 479 yards, with 365 through the air and 114 on the ground. The offense produced 26 first downs to go with 3 trips to the end zone.

Head-to-Head Statistics

The Rams claimed a 42-26 win over the 49ers at Levi's Stadium when these teams last met. The previous 10 matchups have been evenly split, with both teams recording five wins.

Quarterbacks

Brock Purdy

238.5 Passing Yards

Over -114

Under -114

Matthew Stafford

258.5 Passing Yards

Over -114

Under -114

49ers vs Rams Prediction & Picks

Get set for 49ers vs Rams with our full betting breakdown, complete with an expert match prediction, a likely final score, top player prop picks and a value-driven bet builder.

Game Prediction

We’re heading to the totals after finding that the line is set at a generous 48.5 points. Expect this number to be surpassed at -105 for this NFL battle.

Team news and current form always play a key role in shaping our expert NFL picks. We also dig into the latest stats and trends to help deliver the most accurate predictions possible.

Key 49ers vs Rams stats:

• The 48.5 line has been covered in 8 of the last 10 Rams games.
• The 48.5 line has been covered in 4 of the last 5 Rams games.
• The 48.5 line has been covered in the last 2 games between these teams.

Over 48.5 Probability

According to the latest betting odds, our pick has a 51.3% chance of winning. However, our analysts think that the probability is close to 60% taking all factors into consideration. This wager can therefore be backed with confidence.

There are ways to get bigger odds by betting Over on the Totals. Bettors often look to move the line so they can land a more profitable return if the selection wins.

Boost your betting strategy with exclusive offers, free bets, and welcome bonuses—all in our straightforward guide.

Our Game Prediction

Over 48.5 Points @ -105 Bet Now

BetMGM Promo Up To $1500 in Bonus Bets Get Bonus T&C apply. Gamble responsibly 18+

Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Sep 9, 03:25). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Kyren Williams Anytime TD -141

You can place a bet on Kyren Williams (Rams) to record a TD at -141. The Anytime Touchdown Scorer odds look attractive based on the evidence, and we’ll back him to take it to the house.

Latest Kyren Williams Player Prop Odds

Touchdown

Anytime

-115

First

+550

Receiving Yards

Over 10.5

-114

Under 10.5

-114

Rushing Yards

Over 54.5

-114

Under 54.5

-114

---

Brock Purdy Over 243.5 Passing Yards -114

The odds for Brock Purdy (Niners) to rack up over 243.5 passing yards are -114. There’s an opportunity to place a QB Passing Yards bet, with him capable of covering an appealing line.

Latest Brock Purdy Player Prop Odds

Touchdown

Anytime

+450

First

+2200

Passing Yards

Over 238.5

-114

Under 238.5

-114

Rushing Yards

Over 18.5

-114

Under 18.5

-114

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

49ers 23 - 31 Rams

The Rams are capable of landing a victory and we’re going for a correct score line of 31-23 at huge odds. There’s a big return that can be achieved with this wager.

T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

49ers vs Rams Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

The Los Angeles Rams odds have been priced up by the sportsbooks and they are -204 betting favorites to land victory in this game which means a 67% chance of winning. San Francisco 49ers are trading at bigger odds than their opponents and they can be backed at +172.

The spread is 3.5 and the total points line is currently 47.5. NFL bettors love the chance to get an alternative angle by going for a Total wager. If you fancy Over 47.5, this outcome can be backed at -114.

If you’re betting on the National Football League, we recommend visiting the top betting apps and scanning through the many team props and game lines. There’s the opportunity to wager pre-game and in-game.

Moneyline

49ers

+172

Rams

-204

Point Spread

49ers +3.5

-108

Rams -3.5

-112

Total Points

Under 47.5

-106

Over 47.5

-114

The First Touchdown Scorer favorite is Christian McCaffrey at +470. Similar odds can be found if you’re interested in this player to register the final TD.

Touchdown

Christian McCaffrey (49ers)

First TD

+470

Anytime TD

-154

Kyren Williams (Rams)

First TD

+550

Anytime TD

-115

Davante Adams (Rams)

First TD

+750

Anytime TD

+115

Puka Nacua (Rams)

First TD

+800

Anytime TD

+125

Blake Corum (Rams)

First TD

+1100

Anytime TD

+185

Mike Evans (49ers)

First TD

+1400

Anytime TD

+220

George Kittle (49ers)

First TD

+1600

Anytime TD

+310

Colby Parkinson (Rams)

First TD

+1900

Anytime TD

+390

Deebo Samuel (49ers)

First TD

+2000

Anytime TD

+400

Brock Purdy (49ers)

First TD

+2200

Anytime TD

+450

Terrance Ferguson (Rams)

First TD

+2200

Anytime TD

+430

Tyler Higbee (Rams)

First TD

+2200

Anytime TD

+460

De'Zhaun Stribling (49ers)

First TD

+2500

Anytime TD

+480

Jake Tonges (49ers)

First TD

+4000

Anytime TD

+800

Jordan Whittington (Rams)

First TD

+4000

Anytime TD

+1000

Demarcus Robinson (49ers)

First TD

+4500

Anytime TD

+950

Kyle Juszczyk (49ers)

First TD

+5500

Anytime TD

+1100

Davis Allen (Rams)

First TD

+5500

Anytime TD

+1300

Xavier Smith (Rams)

First TD

+6000

Anytime TD

+1400

Tutu Atwell (Rams)

First TD

+6000

Anytime TD

+1400

Max Klare (Rams)

First TD

+6000

Anytime TD

+1400

Konata Mumpfield (Rams)

First TD

+6000

Anytime TD

+1600

James Jordan (49ers)

First TD

+7000

Anytime TD

+1000

CJ Daniels (Rams)

First TD

+7500

Anytime TD

+1900

Kaelon Black (49ers)

First TD

+7500

Anytime TD

+1000

Ronnie Rivers (Rams)

First TD

+10000

Anytime TD

+5000

Matthew Stafford (Rams)

First TD

+10000

Anytime TD

+2500

Jordan Watkins (49ers)

First TD

+10000

Anytime TD

+2200

Luke Farrell (49ers)

First TD

+10000

Anytime TD

+1300

Jacob Cowing (49ers)

First TD

+10000

Anytime TD

+2200

Receiving Yards

Puka Nacua (Rams)

Over 90.5

-114

Under 90.5

-114

Davante Adams (Rams)

Over 52.5

-114

Under 52.5

-114

Mike Evans (49ers)

Over 49.5

-114

Under 49.5

-114

Christian McCaffrey (49ers)

Over 39.5

-114

Under 39.5

-114

George Kittle (49ers)

Over 33.5

-114

Under 33.5

-114

Deebo Samuel (49ers)

Over 28.5

-114

Under 28.5

-114

De'Zhaun Stribling (49ers)

Over 27.5

-114

Under 27.5

-114

Terrance Ferguson (Rams)

Over 24.5

-114

Under 24.5

-114

Colby Parkinson (Rams)

Over 18.5

-114

Under 18.5

-114

Tyler Higbee (Rams)

Over 16.5

-114

Under 16.5

-114

Kyren Williams (Rams)

Over 10.5

-114

Under 10.5

-114

Demarcus Robinson (49ers)

Over 9.5

-114

Under 9.5

-114

Jake Tonges (49ers)

Over 9.5

-114

Under 9.5

-114

Kyle Juszczyk (49ers)

Over 6.5

-114

Under 6.5

-114

Jordan Whittington (Rams)

Over 5.5

-114

Under 5.5

-114

Blake Corum (Rams)

Over 2.5

+102

Under 2.5

-130

Rushing Yards

Christian McCaffrey (49ers)

Over 58.5

-114

Under 58.5

-114

Kyren Williams (Rams)

Over 54.5

-114

Under 54.5

-114

Blake Corum (Rams)

Over 42.5

-114

Under 42.5

-114

Brock Purdy (49ers)

Over 18.5

-114

Under 18.5

-114

Deebo Samuel (49ers)

Over 7.5

-100

Under 7.5

-128

Puka Nacua (Rams)

Over 2.5

+118

Under 2.5

-149

Matthew Stafford (Rams)

Over 0.5

+154

Under 0.5

-200

Passing Yards

Matthew Stafford (Rams)

Over 258.5

-114

Under 258.5

-114

Brock Purdy (49ers)

Over 238.5

-114

Under 238.5

-114

It’s possible to use stats to your advantage when it comes to NFL micro betting, especially if you’re predicting outcomes such as the Next Drive Result. Check out the live team, score and player props and see if you can find an angle.

Latest regular season and playoff games stats.

San Francisco 49ers Stats

Los Angeles Rams Stats

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 7 wins and 3 defeats in the last 10 games on the road

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 8 wins and 2 defeats in the last 10 home games

Point Spread

• +3.5 Betting Line: Have covered the spread in 7 of the last 10 games
• +3.5 Betting Line on the Road: Have covered the spread in 7 of the last 10 games on the road

Point Spread

• -3.5 Betting Line: Have covered the spread in 4 of the last 10 games
• -3.5 Betting Line at Home: Have covered the spread in 7 of the last 10 home games

Total Points

• Game Totals: An average of 51.50 pts in the previous 10 games
• Game Totals on the Road: An average of 50.50 pts in the previous 10 games on the road
• Over 48.5: Covered in 5 of the previous 10 games
• Over 48.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 27.20 pts and allowed 24.30 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 26.40 pts and allowed 24.10 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 58.00 pts in the previous 10 games
• Game Totals at Home: An average of 46.70 pts in the previous 10 home games
• Over 48.5: Covered in 8 of the previous 10 games
• Over 48.5 at Home: Covered in 4 of the previous 10 home games
• Team Totals: Have scored an average of 32.70 pts and allowed 25.30 pts in the last 10 games
• Team Totals at Home: Have scored an average of 28.30 pts and allowed 18.40 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 339.60 Yds. Allowed 337.90 Yds
• Rushing Yards: Gained 112.00 Yds. Allowed 116.80 Yds
• Passing Yards: Gained 227.60 Yds. Allowed 221.10 Yds
• Total Touchdowns: Scored 3.30 TD. Allowed 3.00 TD
• Rushing Touchdowns: Scored 1.00 TD. Allowed 1.20 TD
• Passing Touchdowns: Scored 2.20 TD. Allowed 1.60 TD
• Total 1st Downs: Picked up 22.10. Allowed 20.60
• Total Turnovers: Committed 1.40. Committed by opponents 0.90
• Total Penalties: Committed 3.30. Committed by opponents 5.90
• Penalty Yards: Lost 28.00 Yds. Gained 40.40 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 433.00 Yds. Allowed 348.40 Yds
• Rushing Yards: Gained 135.30 Yds. Allowed 119.50 Yds
• Passing Yards: Gained 297.70 Yds. Allowed 228.90 Yds
• Total Touchdowns: Scored 3.90 TD. Allowed 3.10 TD
• Rushing Touchdowns: Scored 1.20 TD. Allowed 0.70 TD
• Passing Touchdowns: Scored 2.20 TD. Allowed 1.70 TD
• Total 1st Downs: Picked up 23.80. Allowed 19.10
• Total Turnovers: Committed 0.90. Committed by opponents 1.30
• Total Penalties: Committed 4.20. Committed by opponents 5.10
• Penalty Yards: Lost 30.20 Yds. Gained 38.30 Yds

Last 10 Games on the Road

• Total Yards: Gained 328.10 Yds. Allowed 352.10 Yds
• Rushing Yards: Gained 93.30 Yds. Allowed 112.50 Yds
• Passing Yards: Gained 234.80 Yds. Allowed 239.60 Yds
• Total Touchdowns: Scored 2.90 TD. Allowed 2.90 TD
• Rushing Touchdowns: Scored 0.70 TD. Allowed 0.90 TD
• Passing Touchdowns: Scored 2.10 TD. Allowed 1.90 TD
• Total 1st Downs: Picked up 20.90. Allowed 20.50
• Total Turnovers: Committed 1.10. Committed by opponents 1.10
• Total Penalties: Committed 4.20. Committed by opponents 6.60
• Penalty Yards: Lost 32.60 Yds. Gained 44.30 Yds

Last 10 Home Games

• Total Yards: Gained 384.30 Yds. Allowed 315.40 Yds
• Rushing Yards: Gained 108.80 Yds. Allowed 96.90 Yds
• Passing Yards: Gained 275.50 Yds. Allowed 218.50 Yds
• Total Touchdowns: Scored 3.40 TD. Allowed 1.80 TD
• Rushing Touchdowns: Scored 0.60 TD. Allowed 0.30 TD
• Passing Touchdowns: Scored 2.60 TD. Allowed 1.50 TD
• Total 1st Downs: Picked up 22.20. Allowed 18.80
• Total Turnovers: Committed 0.70. Committed by opponents 1.70
• Total Penalties: Committed 5.00. Committed by opponents 5.80
• Penalty Yards: Lost 39.90 Yds. Gained 41.50 Yds

Where to Bet on American Football Games

Top American Football Pages