Broncos vs Cardinals Prediction, Picks & Odds | 25 Oct 2026

Broncos vs Cardinals Predictions

Best Bet

Broncos -4.5 @ -108

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Back the Broncos against the spread, with a generous betting line of -4.5 that they get the better of the Cardinals. There are odds of -108 that are currently on offer for this value pick.

We've selected our preferred Broncos vs Cardinals wagers, including our Best Bet, Player Props, Same Game Parlay and Correct Score Prediction. Browse the dedicated sections below for an in-depth look at the card.

Broncos vs Cardinals Preview

The Denver Broncos battle the Arizona Cardinals at State Farm Stadium, with kickoff scheduled for 15:05 on Sunday, October 25.

Denver Broncos claimed a home victory in their previous game. A 17-14 (OT) triumph against Seattle Seahawks at Empower Field at Mile High made it back-to-back wins. The Broncos totaled 168 yards, split between 94 passing and 74 rushing yards. They moved the chains 13 times and crossed the goal line twice.

Arizona Cardinals have suffered back-to-back home defeats. In their last game, they beat Los Angeles Rams 18-16 on the road at SoFi Stadium. The Cardinals totaled 338 yards, split between 218 passing and 120 rushing yards. They allowed 19 first downs and picked up 22.

H2H: 24-15 Victory for Broncos in Previous H2H Clash

The Broncos had the edge in the most recent matchup between these teams. At Empower Field at Mile High, they recorded a 24-15 win over the Cards.

Quarterbacks

Bo Nix

219.5 Passing Yards

Over -114

Under -114

Jacoby Brissett

225.5 Passing Yards

Over -114

Under -114

Best Bet

Our pick is for the Broncos to cover the appealing -4.5 line in this NFL battle. They should be able to win by a more comfortable margin and odds of -108 are available for the favorites.

Key stats supporting our main match prediction:

• The -4.5 line has been covered by Broncos in 3 of their last 5 games on the road.
• The +4.5 line hasn’t been covered by Cardinals in 4 consecutive games at home.
• The +4.5 line hasn’t been covered by Cardinals in 8 of their last 10 games.
• The +4.5 line hasn’t been covered by Cardinals in 11 of their last 20 games.

The NFL handicappers at Sportsgambler.com regularly track injury updates and pair that with current form. We also tap into a deep stats database to highlight the key numbers that help shape our predictions.

Broncos -4.5 Probability

Based on the odds from the top NFL betting sites, there’s a 51.8% likelihood of our pick delivering a return. However, our analysts think that the probability is close to 60% taking all factors into consideration. This is why we can recommend this bet.

If you want a viable alternative to backing the Broncos on the spread, then the Winning Margin lines could be up your street. Choose from a range of options.

Discover the best value in betting. Our expert guide lists today’s top free bets, promo codes and new customer bonuses.

Broncos -4.5 @ -108 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Oct 23, 21:25). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Bo Nix Over 219.5 Passing Yards -114

Bo Nix (Broncos) is priced at -114 to exceed 219.5 passing yards. We feel confident that he’ll cover the QB Passing Yards line, which looks generous.

Latest Bo Nix Player Prop Odds

Touchdown

Anytime

+380

First

+1700

Passing Yards

Over 219.5

-114

Under 219.5

-114

Rushing Yards

Over 10.5

-114

Under 10.5

-114

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Jaylen Waddle Over 50.5 Receiving Yards -114

The odds for Jaylen Waddle (Broncos) to surpass 50.5 receiving yards are -114. We're confident in him covering the Player Receiving Yards line and hitting our Over bet.

Latest Jaylen Waddle Player Prop Odds

Touchdown

Anytime

+190

First

+1100

Receiving Yards

Over 50.5

-114

Under 50.5

-114

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Broncos 31 - 21 Cardinals

The Broncos to win by a 31-21 scoreline could be worth a chance. There’s a massive potential return if you can land this bet on the money and it should provide some entertainment.

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Broncos vs Cardinals Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

For this game, the sportsbooks’ Moneyline betting odds mean Denver Broncos are -227 favorites to win and that means a 69% chance of landing a victory. At +188, Arizona Cardinals are regarded as having a lower probability of winning.

The spread is calculated to be 4.5, while total points comes in at 43.5. A Total bet is always available and can often provide value selections. Those that want to back Under 43.5 can find odds of -110 available.

The good news is that you can access a wide range of game lines and team props for every National Football League matchup. The best betting apps offer a great selection of pre-game and in-game wagering options.

Moneyline

Broncos

-227

Cardinals

+188

Point Spread

Broncos -4.5

-108

Cardinals +4.5

-112

Total Points

Under 43.5

-110

Over 43.5

-110

Favorite J.K. Dobbins is priced at +550 to be the first player to score a touchdown. There’s also the opportunity to back him to score a TD at anytime at odds of +125.

Touchdown

J.K. Dobbins (Broncos)

First TD

+550

Anytime TD

+125

Trey McBride (Cardinals)

First TD

+900

Anytime TD

+135

Jeremiyah Love (Cardinals)

First TD

+900

Anytime TD

+160

Tyler Allgeier (Cardinals)

First TD

+1100

Anytime TD

+200

Jaylen Waddle (Broncos)

First TD

+1100

Anytime TD

+190

Courtland Sutton (Broncos)

First TD

+1200

Anytime TD

+240

Bam Knight (Cardinals)

First TD

+1200

Anytime TD

+260

Michael Wilson (Cardinals)

First TD

+1400

Anytime TD

+240

RJ Harvey (Broncos)

First TD

+1500

Anytime TD

+280

Jonah Coleman (Broncos)

First TD

+1700

Anytime TD

+370

Bo Nix (Broncos)

First TD

+1700

Anytime TD

+380

Evan Engram (Broncos)

First TD

+1800

Anytime TD

+390

Kendrick Bourne (Cardinals)

First TD

+1900

Anytime TD

+360

Troy Franklin (Broncos)

First TD

+2700

Anytime TD

+600

Marvin Mims Jr. (Broncos)

First TD

+2700

Anytime TD

+550

Jalen Brooks (Cardinals)

First TD

+3000

Anytime TD

+700

Adam Trautman (Broncos)

First TD

+3000

Anytime TD

+800

Jacoby Brissett (Cardinals)

First TD

+3300

Anytime TD

+800

Elijah Higgins (Cardinals)

First TD

+3500

Anytime TD

+800

Tyler Badie (Broncos)

First TD

+4000

Anytime TD

+950

Nate Adkins (Broncos)

First TD

+4000

Anytime TD

+1000

Lil'Jordan Humphrey (Broncos)

First TD

+5500

Anytime TD

+1500

Teagan Quitoriano (Cardinals)

First TD

+6500

Anytime TD

+1600

Shawn Bowman (Cardinals)

First TD

+7500

Anytime TD

+1600

Reggie Virgil (Cardinals)

First TD

+8000

Anytime TD

+1900

Adam Prentice (Broncos)

First TD

+8000

Anytime TD

+2000

Dallen Bentley (Broncos)

First TD

+8000

Anytime TD

+2000

Devin Duvernay (Cardinals)

First TD

+8000

Anytime TD

+2000

Simi Fehoko (Cardinals)

First TD

+10000

Anytime TD

+4000

Receiving Yards

Trey McBride (Cardinals)

Over 63.5

-114

Under 63.5

-114

Jaylen Waddle (Broncos)

Over 50.5

-114

Under 50.5

-114

Michael Wilson (Cardinals)

Over 48.5

-114

Under 48.5

-114

Kendrick Bourne (Cardinals)

Over 34.5

-114

Under 34.5

-114

Courtland Sutton (Broncos)

Over 33.5

-114

Under 33.5

-114

RJ Harvey (Broncos)

Over 24.5

-108

Under 24.5

-120

Evan Engram (Broncos)

Over 22.5

-114

Under 22.5

-114

Jalen Brooks (Cardinals)

Over 16.5

-114

Under 16.5

-114

Marvin Mims Jr. (Broncos)

Over 14.5

-114

Under 14.5

-114

Troy Franklin (Broncos)

Over 14.5

-114

Under 14.5

-114

Elijah Higgins (Cardinals)

Over 12.5

-114

Under 12.5

-114

Tyler Allgeier (Cardinals)

Over 10.5

-114

Under 10.5

-114

J.K. Dobbins (Broncos)

Over 4.5

-114

Under 4.5

-114

Rushing Yards

J.K. Dobbins (Broncos)

Over 47.5

-114

Under 47.5

-114

Bam Knight (Cardinals)

Over 40.5

-114

Under 40.5

-114

Tyler Allgeier (Cardinals)

Over 30.5

-114

Under 30.5

-114

Jonah Coleman (Broncos)

Over 19.5

-114

Under 19.5

-114

RJ Harvey (Broncos)

Over 14.5

-108

Under 14.5

-120

Bo Nix (Broncos)

Over 10.5

-114

Under 10.5

-114

Jacoby Brissett (Cardinals)

Over 6.5

-114

Under 6.5

-114

Passing Yards

Jacoby Brissett (Cardinals)

Over 225.5

-114

Under 225.5

-114

Bo Nix (Broncos)

Over 219.5

-114

Under 219.5

-114

Cards Have Lost Nine Straight at Home

The Cardinals have dropped their last nine at State Farm Stadium. They own a 1-9 mark in their past 10 home games, putting up 20.10 points on average and giving up 30.90.

The Broncos have seven wins and three losses in the last 10 games on the road, scoring 19.00 points per contest and conceding 19.40.

The previous meeting at State Farm Stadium saw the Cards defeat the Broncos 18-17.

Last 10 Games		W-L	P	PF	PA	O43.5	U43.5
Cardinals Home Stats		1-9	51.00	20.10	30.90	7	3
Broncos Away Stats		7-3	38.40	19.00	19.40	1	9

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O43.5 = Games Over 43.5 Points
• U43.5 = Games Under 43.5 Points

Latest regular season and playoff games stats.

Denver Broncos Stats

Arizona Cardinals Stats

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 7 wins and 3 defeats in the last 10 games on the road

Moneyline

• 2 wins and 8 defeats in the last 10 games
• 1 win and 9 defeats in the last 10 home games

Point Spread

• -4.5 Betting Line: Have covered the spread in 4 of the last 10 games
• -4.5 Betting Line on the Road: Have covered the spread in 3 of the last 10 games on the road

Point Spread

• +4.5 Betting Line: Have covered the spread in 2 of the last 10 games
• +4.5 Betting Line at Home: Have covered the spread in 5 of the last 10 home games

Total Points

• Game Totals: An average of 37.40 pts in the previous 10 games
• Game Totals on the Road: An average of 38.40 pts in the previous 10 games on the road
• Over 43.5: Covered in 2 of the previous 10 games
• Over 43.5 on the Road: Covered in 1 of the previous 10 games on the road
• Team Totals: Have scored an average of 19.30 pts and allowed 18.10 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 19.00 pts and allowed 19.40 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 51.70 pts in the previous 10 games
• Game Totals at Home: An average of 51.00 pts in the previous 10 home games
• Over 43.5: Covered in 7 of the previous 10 games
• Over 43.5 at Home: Covered in 7 of the previous 10 home games
• Team Totals: Have scored an average of 19.90 pts and allowed 31.80 pts in the last 10 games
• Team Totals at Home: Have scored an average of 20.10 pts and allowed 30.90 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 258.60 Yds. Allowed 310.10 Yds
• Rushing Yards: Gained 89.80 Yds. Allowed 135.80 Yds
• Passing Yards: Gained 168.80 Yds. Allowed 174.30 Yds
• Total Touchdowns: Scored 1.90 TD. Allowed 1.80 TD
• Rushing Touchdowns: Scored 0.30 TD. Allowed 0.10 TD
• Passing Touchdowns: Scored 0.40 TD. Allowed 0.40 TD
• Total 1st Downs: Picked up 16.60. Allowed 18.70
• Total Turnovers: Committed 1.00. Committed by opponents 1.70
• Total Penalties: Committed 5.50. Committed by opponents 5.40
• Penalty Yards: Lost 35.60 Yds. Gained 47.20 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 302.10 Yds. Allowed 366.80 Yds
• Rushing Yards: Gained 90.30 Yds. Allowed 128.30 Yds
• Passing Yards: Gained 211.80 Yds. Allowed 238.50 Yds
• Total Touchdowns: Scored 2.00 TD. Allowed 3.90 TD
• Rushing Touchdowns: Scored 0.00 TD. Allowed 0.50 TD
• Passing Touchdowns: Scored 0.80 TD. Allowed 1.30 TD
• Total 1st Downs: Picked up 18.80. Allowed 22.40
• Total Turnovers: Committed 1.10. Committed by opponents 1.00
• Total Penalties: Committed 6.00. Committed by opponents 4.90
• Penalty Yards: Lost 54.00 Yds. Gained 38.30 Yds

Last 10 Games on the Road

• Total Yards: Gained 289.70 Yds. Allowed 280.20 Yds
• Rushing Yards: Gained 104.20 Yds. Allowed 110.00 Yds
• Passing Yards: Gained 185.50 Yds. Allowed 170.20 Yds
• Total Touchdowns: Scored 1.90 TD. Allowed 1.90 TD
• Rushing Touchdowns: Scored 0.70 TD. Allowed 0.20 TD
• Passing Touchdowns: Scored 0.70 TD. Allowed 0.80 TD
• Total 1st Downs: Picked up 17.40. Allowed 17.70
• Total Turnovers: Committed 0.90. Committed by opponents 0.70
• Total Penalties: Committed 7.10. Committed by opponents 4.50
• Penalty Yards: Lost 56.50 Yds. Gained 35.20 Yds

Last 10 Home Games

• Total Yards: Gained 316.20 Yds. Allowed 364.20 Yds
• Rushing Yards: Gained 83.30 Yds. Allowed 133.10 Yds
• Passing Yards: Gained 232.90 Yds. Allowed 231.10 Yds
• Total Touchdowns: Scored 2.30 TD. Allowed 3.70 TD
• Rushing Touchdowns: Scored 0.60 TD. Allowed 1.00 TD
• Passing Touchdowns: Scored 1.10 TD. Allowed 1.60 TD
• Total 1st Downs: Picked up 18.50. Allowed 22.80
• Total Turnovers: Committed 1.40. Committed by opponents 1.20
• Total Penalties: Committed 8.00. Committed by opponents 5.30
• Penalty Yards: Lost 57.60 Yds. Gained 46.80 Yds

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