49ers vs Falcons Prediction, Picks & Odds | 25 Oct 2026

49ers vs Falcons Predictions

Best Bet

49ers Moneyline @ -143

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The Niners should be able to outscore the Falcons and our prediction is to side with them on the Moneyline. There is a tempting -143 should you wish to follow suit.

Our expert Niners vs Falcons betting coverage includes our Best Bet, Player Props, Same Game Parlay and Correct Score Prediction. Scroll down to see the full breakdown and reasoning behind the card.

49ers vs Falcons Preview

The San Francisco 49ers square off against the Atlanta Falcons at Mercedes-Benz Stadium, with kickoff scheduled for 12:00 on Sunday, October 25.

San Francisco 49ers made it six consecutive wins after a 23-17 home success over Washington Commanders at Levi's Stadium. The 49ers recorded 375 total yards, made up of 249 through the air and 126 on the ground. They moved the chains 20 times and produced 3 touchdowns.

Atlanta Falcons have lost on their last three home outings. In a recent game at Mercedes-Benz Stadium, they were turned over 31-23 by Chicago Bears. The Falcons put up 257 yards, including 194 passing and 63 rushing yards. The offense moved the chains 13 times and produced 3 touchdowns, each one a passing score.

H2H: Niners Too Good for Falcons in Last H2H

The Niners won the last matchup between the pair. Enjoying a 20-10 triumph when facing the Falcons at Levi's Stadium. There has been two wins apiece in the past 4 H2H meetings.

Quarterbacks

Brock Purdy

240.5 Passing Yards

Over -114

Under -114

Michael Penix Jr.

227.5 Passing Yards

Over -114

Under -114

Best Bet

The value wager could involve heading to the Moneyline where you can back the Niners to win this NFL matchup. Our pick is currently available at an attractive -143.

Key stats supporting our main match prediction:

• 49ers have won 6 consecutive games.
• 49ers have won 8 of their last 10 games.
• 49ers have won 15 of their last 20 games.
• Falcons have lost their last 3 games at home.
• Falcons have lost 4 of their last 6 games this season.
• Falcons have lost 6 of their last 10 games at home.

It’s important to know which players are unavailable for the upcoming action along with the current form of each franchise. If you're after stats, you're in the right place because they form the foundation of our NFL picks.

Niners Moneyline Probability

According to the top sportsbooks, there’s a 58.8% likelihood of our pick landing a return. After careful examination, our analysts have this probability somewhere between 65-70%. It is the reason why we are recommending this wager.

If you can correctly predict that the Niners will triumph along with the number of points, then you are able to combine the two picks and get bigger odds on the Result & Total lines.

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49ers Moneyline @ -143 Watch Live Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Oct 23, 18:25). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: George Kittle Anytime TD +120

George Kittle (Niners) can be backed at +120 to reach the end zone. The Anytime Touchdown Scorer odds look attractive based on the evidence, and we’ll back him to take it to the house.

Latest George Kittle Player Prop Odds

Touchdown

Anytime

+120

First

+900

Receiving Yards

Over 69.5

-114

Under 69.5

-114

---

Michael Penix Jr. Over 227.5 Passing Yards -114

Michael Penix Jr. (Falcons) is available at -114 to record more than 227.5 passing yards. We believe it makes sense to stick with him on the Over and bettors can be confident in this QB Passing Yards pick.

Latest Michael Penix Jr. Player Prop Odds

Touchdown

Anytime

+850

First

+4000

Passing Yards

Over 227.5

-114

Under 227.5

-114

Rushing Yards

Over 2.5

-102

Under 2.5

-128

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

49ers 27 - 17 Falcons

The Niners might get the upper hand and it might be worth backing them to achieve a specific correct score. Try an outcome of 27-17 for a big possible return from your stake.

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49ers vs Falcons Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

The sportsbooks’ betting odds have San Francisco 49ers as -143 favorites for this game, implying that they are 59% likely to win. Atlanta Falcons are the underdogs at +120 and they’re regarded as least likely to win.

The spread is calculated to be 2.5, while total points comes in at 49.5. The advantage of the Totals is that you only have to choose from one of two options. There’s the chance to back Under 49.5 at -110.

The top NFL sportsbooks offer a huge selection of game lines and team props when it comes to this popular league. Make sure you look through all the available options before deciding which bet to place.

Moneyline

49ers

-143

Falcons

+120

Point Spread

49ers -2.5

-114

Falcons +2.5

-106

Total Points

Under 49.5

-110

Over 49.5

-110

Those interested in Bijan Robinson to score a touchdown at anytime are able to get -312. There is an opportunity to back the favorite to get the first TD at odds of +290.

Touchdown

Bijan Robinson (Falcons)

First TD

+290

Anytime TD

-312

Christian McCaffrey (49ers)

First TD

+360

Anytime TD

-238

George Kittle (49ers)

First TD

+900

Anytime TD

+120

Drake London (Falcons)

First TD

+1000

Anytime TD

+135

Kyle Pitts (Falcons)

First TD

+1800

Anytime TD

+270

Brock Purdy (49ers)

First TD

+1800

Anytime TD

+320

Kaelon Black (49ers)

First TD

+2000

Anytime TD

+390

Christian Kirk (49ers)

First TD

+2200

Anytime TD

+400

Brandin Cooks (49ers)

First TD

+2200

Anytime TD

+450

Jahan Dotson (Falcons)

First TD

+2500

Anytime TD

+420

Jordan Watkins (49ers)

First TD

+2700

Anytime TD

+500

Kyle Juszczyk (49ers)

First TD

+2700

Anytime TD

+550

Khalil Herbert (49ers)

First TD

+3500

Anytime TD

+600

Michael Penix Jr. (Falcons)

First TD

+4000

Anytime TD

+850

Jacob Cowing (49ers)

First TD

+4500

Anytime TD

+850

Luke Farrell (49ers)

First TD

+4500

Anytime TD

+1000

Zachariah Branch (Falcons)

First TD

+5000

Anytime TD

+950

Charlie Woerner (Falcons)

First TD

+5500

Anytime TD

+1200

Olamide Zaccheaus (Falcons)

First TD

+5500

Anytime TD

+1100

Austin Hooper (Falcons)

First TD

+6000

Anytime TD

+1200

James Jordan (49ers)

First TD

+10000

Anytime TD

+2200

Chris Blair (Falcons)

First TD

+10000

Anytime TD

+2500

Brayden Willis (49ers)

First TD

+10000

Anytime TD

+2700

Malik Turner (49ers)

First TD

+10000

Anytime TD

+2700

Nick Muse (Falcons)

First TD

+10000

Anytime TD

+3300

Receiving Yards

Drake London (Falcons)

Over 83.5

-114

Under 83.5

-114

George Kittle (49ers)

Over 69.5

-114

Under 69.5

-114

Christian McCaffrey (49ers)

Over 44.5

-114

Under 44.5

-114

Kyle Pitts (Falcons)

Over 34.5

-114

Under 34.5

-114

Jahan Dotson (Falcons)

Over 29.5

-114

Under 29.5

-114

Bijan Robinson (Falcons)

Over 28.5

-114

Under 28.5

-114

Christian Kirk (49ers)

Over 27.5

-114

Under 27.5

-114

Brandin Cooks (49ers)

Over 23.5

-114

Under 23.5

-114

Jordan Watkins (49ers)

Over 21.5

-114

Under 21.5

-114

Kyle Juszczyk (49ers)

Over 11.5

-114

Under 11.5

-114

Olamide Zaccheaus (Falcons)

Over 7.5

-108

Under 7.5

-120

Zachariah Branch (Falcons)

Over 5.5

-102

Under 5.5

-128

Austin Hooper (Falcons)

Over 4.5

-114

Under 4.5

-114

Brian Robinson Jr. (Falcons)

Over 3.5

-114

Under 3.5

-114

Rushing Yards

Bijan Robinson (Falcons)

Over 88.5

-114

Under 88.5

-114

Christian McCaffrey (49ers)

Over 60.5

-114

Under 60.5

-114

Kaelon Black (49ers)

Over 28.5

-114

Under 28.5

-114

Brian Robinson Jr. (Falcons)

Over 26.5

-114

Under 26.5

-114

Brock Purdy (49ers)

Over 19.5

-114

Under 19.5

-114

Michael Penix Jr. (Falcons)

Over 2.5

-102

Under 2.5

-128

Passing Yards

Brock Purdy (49ers)

Over 240.5

-114

Under 240.5

-114

Michael Penix Jr. (Falcons)

Over 227.5

-114

Under 227.5

-114

Falcons Currently at Three Home Losses in a Row

The Falcons have come up short in three consecutive outings at Mercedes-Benz Stadium. They are 4-6 in their last 10 home games, averaging 19.90 points on offense and surrendering 27.80 on defense.

The Niners have a 7-3 record in their last 10 games away from home, posting 27.10 points per contest while yielding 23.30.

When the teams last met at Mercedes-Benz Stadium, the Falcons beat the Niners 28-14.

Last 10 Games		W-L	P	PF	PA	O49.5	U49.5
Falcons Home Stats		4-6	47.70	19.90	27.80	5	5
49ers Away Stats		7-3	50.40	27.10	23.30	4	6

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O49.5 = Games Over 49.5 Points
• U49.5 = Games Under 49.5 Points

Latest regular season and playoff games stats.

San Francisco 49ers Stats

Atlanta Falcons Stats

Moneyline

• 8 wins and 2 defeats in the last 10 games
• 7 wins and 3 defeats in the last 10 games on the road

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 home games

Point Spread

• -2.5 Betting Line: Have covered the spread in 8 of the last 10 games
• -2.5 Betting Line on the Road: Have covered the spread in 7 of the last 10 games on the road

Point Spread

• +2.5 Betting Line: Have covered the spread in 6 of the last 10 games
• +2.5 Betting Line at Home: Have covered the spread in 4 of the last 10 home games

Total Points

• Game Totals: An average of 47.20 pts in the previous 10 games
• Game Totals on the Road: An average of 50.40 pts in the previous 10 games on the road
• Over 49.5: Covered in 3 of the previous 10 games
• Over 49.5 on the Road: Covered in 4 of the previous 10 games on the road
• Team Totals: Have scored an average of 25.10 pts and allowed 22.10 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 27.10 pts and allowed 23.30 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 48.40 pts in the previous 10 games
• Game Totals at Home: An average of 47.70 pts in the previous 10 home games
• Over 49.5: Covered in 5 of the previous 10 games
• Over 49.5 at Home: Covered in 5 of the previous 10 home games
• Team Totals: Have scored an average of 24.30 pts and allowed 24.10 pts in the last 10 games
• Team Totals at Home: Have scored an average of 19.90 pts and allowed 27.80 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 346.60 Yds. Allowed 318.90 Yds
• Rushing Yards: Gained 120.50 Yds. Allowed 114.60 Yds
• Passing Yards: Gained 226.10 Yds. Allowed 204.30 Yds
• Total Touchdowns: Scored 3.20 TD. Allowed 2.30 TD
• Rushing Touchdowns: Scored 0.50 TD. Allowed 0.70 TD
• Passing Touchdowns: Scored 0.70 TD. Allowed 0.60 TD
• Total 1st Downs: Picked up 19.90. Allowed 19.10
• Total Turnovers: Committed 1.30. Committed by opponents 0.70
• Total Penalties: Committed 4.80. Committed by opponents 6.10
• Penalty Yards: Lost 46.80 Yds. Gained 45.20 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 343.70 Yds. Allowed 337.20 Yds
• Rushing Yards: Gained 142.80 Yds. Allowed 94.20 Yds
• Passing Yards: Gained 200.90 Yds. Allowed 243.00 Yds
• Total Touchdowns: Scored 2.70 TD. Allowed 2.70 TD
• Rushing Touchdowns: Scored 0.30 TD. Allowed 0.50 TD
• Passing Touchdowns: Scored 1.00 TD. Allowed 0.70 TD
• Total 1st Downs: Picked up 19.20. Allowed 19.30
• Total Turnovers: Committed 1.60. Committed by opponents 1.20
• Total Penalties: Committed 7.50. Committed by opponents 6.60
• Penalty Yards: Lost 61.50 Yds. Gained 49.60 Yds

Last 10 Games on the Road

• Total Yards: Gained 317.80 Yds. Allowed 330.50 Yds
• Rushing Yards: Gained 105.00 Yds. Allowed 113.60 Yds
• Passing Yards: Gained 212.80 Yds. Allowed 216.90 Yds
• Total Touchdowns: Scored 3.10 TD. Allowed 2.60 TD
• Rushing Touchdowns: Scored 0.70 TD. Allowed 0.90 TD
• Passing Touchdowns: Scored 1.60 TD. Allowed 1.30 TD
• Total 1st Downs: Picked up 19.60. Allowed 18.60
• Total Turnovers: Committed 1.40. Committed by opponents 1.40
• Total Penalties: Committed 3.90. Committed by opponents 6.30
• Penalty Yards: Lost 33.30 Yds. Gained 45.10 Yds

Last 10 Home Games

• Total Yards: Gained 317.60 Yds. Allowed 357.60 Yds
• Rushing Yards: Gained 122.60 Yds. Allowed 121.50 Yds
• Passing Yards: Gained 195.00 Yds. Allowed 236.10 Yds
• Total Touchdowns: Scored 2.00 TD. Allowed 3.10 TD
• Rushing Touchdowns: Scored 0.90 TD. Allowed 0.50 TD
• Passing Touchdowns: Scored 0.80 TD. Allowed 1.70 TD
• Total 1st Downs: Picked up 17.10. Allowed 19.40
• Total Turnovers: Committed 1.60. Committed by opponents 1.10
• Total Penalties: Committed 6.20. Committed by opponents 6.80
• Penalty Yards: Lost 47.70 Yds. Gained 58.80 Yds

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