Dolphins vs 49ers Prediction, Picks & Odds | 20 Sep 2026

NFL Betting Preview: Dolphins vs Niners

The Miami Dolphins battle the San Francisco 49ers at Levi's Stadium, with kickoff scheduled for 16:25 on Sunday, September 20.

The Dolphins can give a good account of themselves against the Niners. They can prevent a big loss and there is -115 available that the underdogs cover the +13.5 spread.

The 49ers return to the United States after opening the season in Australia, with San Francisco facing a Miami team now led by Malik Willis. Brock Purdy and a deep 49ers offense present a significant road test for a Dolphins team looking to establish itself under its new quarterback.

Miami Dolphins opened their campaign with a 27-13 road defeat against Las Vegas Raiders at Allegiant Stadium. Miami finished with 259 total yards, including 185 net passing yards and 74 on the ground, while recording 13 first downs and scoring one touchdown.

Malik Willis completed 15 of 27 passes for 220 yards and an interception in his Dolphins debut, while also rushing for Miami's only touchdown on a 14-yard run. The offense struggled to sustain drives, converting just two of 10 third-down opportunities and allowing Willis to be sacked five times.

San Francisco 49ers kicked off their season with a 27-7 win against Los Angeles Rams at the Melbourne Cricket Ground in the NFL's first regular-season game in Australia. San Francisco generated 379 total yards, including 205 through the air and 174 on the ground, while recording 23 first downs and scoring three touchdowns.

Brock Purdy completed 25 of 34 passes for 205 yards and three touchdowns with one interception. Christian McCaffrey rushed for 68 yards and rookie Kaelon Black added 65, while San Francisco's defense held the Rams to seven points in an impressive all-around performance.

Head-to-Head Statistics

The last matchup between the Dolphins and the Niners saw the former win. It was a 29-17 scoreline at Hard Rock Stadium. The past 3 clashes between these teams have seen two Dolphins wins.

Quarterbacks

Malik Willis

185.5 Passing Yards

Over -114

Under -114

Brock Purdy

238.5 Passing Yards

Over -114

Under -114

Dolphins vs 49ers Prediction & Picks

Our expert Dolphins vs 49ers tips include betting advice on all fronts — from a main match prediction and player prop guidance to a correct score selection and a ready-made bet builder.

Game Prediction

The underdogs have been given a sizeable +13.5 on the spread and we’re looking to take advantage. Back the -115 that the Dolphins avoid a big defeat in this NFL battle.

Incoming team news often impacts the betting lines and odds in significant ways. Our NFL handicappers factor this in alongside recent form, while key stats are also carefully weighed to strengthen each pick.

Key Dolphins vs 49ers stats:

• The +13.5 line has been covered by Dolphins in 14 of their last 20 games.
• The +13.5 line has been covered by Dolphins in 6 of their last 10 games.
• The -13.5 line hasn’t been covered by 49ers in 10 consecutive games at home.
• The -13.5 line hasn’t been covered by 49ers in 18 of their last 20 games at home.
• The -13.5 line hasn’t been covered by 49ers in 2 of their last 3 games against Dolphins.

Fins +13.5 Probability

According to the best NFL sportsbooks, our pick has a 53.5% chance of winning. However, we have this figure at close to 60% based on our in-depth research. It is therefore regarded as a value bet.

If the odds on display doesn’t appeal, you can make the choice to secure a bigger price by moving the line for your point spread pick. It’s a case of taking a view which you are happy with.

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Our Game Prediction

Dolphins +13.5 @ -115 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Sep 18, 22:25). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Mike Evans Anytime TD +140

Mike Evans (Niners) can be backed at +140 to score a TD. The Anytime Touchdown Scorer odds look attractive based on the evidence, and we’ll back him to take it to the house.

Latest Mike Evans Player Prop Odds

Touchdown

Anytime

+135

First

+750

Receiving Yards

Over 48.5

-114

Under 48.5

-114

---

George Kittle Under 41.5 Receiving Yards -114

George Kittle (Dolphins) is available at -114 to have less than 41.5 receiving yards. He could struggle to reach the Player Receiving Yards line, making this prop bet highly appealing.

Latest George Kittle Player Prop Odds

Touchdown

Anytime

+185

First

+950

Receiving Yards

Over 39.5

-114

Under 39.5

-114

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Dolphins 17 - 21 49ers

There’s every chance that this is going to be a close battle and we’ll have a play on the 49ers enjoying a 21-17 winning scoreline. Hopefully this can go close.

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Dolphins vs 49ers Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

With an estimated 91% chance of winning, the sportsbooks are taking no chances with their -1000 betting odds about San Francisco 49ers triumphing in this game. For those wanting to oppose the market leader, you can get +660 about Miami Dolphins.

13.5 is the spread and 45.5 is the total points line. There are many ways to bet on the NFL including the Totals. Those who wager Under 45.5 can get -120.

National Football League bettors are spoilt for choice thanks to the hundreds of team props and game lines which are available for every matchup on the coupon. Head to the top sportsbooks and find the best value picks.

Moneyline

Dolphins

+660

49ers

-1000

Point Spread

Dolphins +13.5

-115

49ers -13.5

-105

Total Points

Under 45.5

-120

Over 45.5

-102

Christian McCaffrey is the First Touchdown Scorer favorite at +260. Alternatively, there’s the chance to simply back him to score a TD anytime at -250.

Touchdown

Christian McCaffrey (49ers)

First TD

+260

Anytime TD

-250

Mike Evans (49ers)

First TD

+750

Anytime TD

+135

De'Von Achane (Dolphins)

First TD

+950

Anytime TD

+140

George Kittle (49ers)

First TD

+950

Anytime TD

+185

Deebo Samuel (49ers)

First TD

+1100

Anytime TD

+220

Kaelon Black (49ers)

First TD

+1400

Anytime TD

+290

Demarcus Robinson (49ers)

First TD

+1400

Anytime TD

+310

Brock Purdy (49ers)

First TD

+1600

Anytime TD

+310

Malik Willis (Dolphins)

First TD

+1800

Anytime TD

+330

Malik Washington (Dolphins)

First TD

+2700

Anytime TD

+440

Luke Farrell (49ers)

First TD

+2700

Anytime TD

+750

Caleb Douglas (Dolphins)

First TD

+3000

Anytime TD

+470

Greg Dulcich (Dolphins)

First TD

+3500

Anytime TD

+600

Chris Bell (Dolphins)

First TD

+3500

Anytime TD

+700

Kyle Juszczyk (49ers)

First TD

+4000

Anytime TD

+950

Jacob Cowing (49ers)

First TD

+4500

Anytime TD

+1100

Ollie Gordon II (Dolphins)

First TD

+6000

Anytime TD

+1100

Jalen Tolbert (Dolphins)

First TD

+7500

Anytime TD

+1400

Kevin Coleman Jr. (Dolphins)

First TD

+7500

Anytime TD

+1400

Will Kacmarek (Dolphins)

First TD

+7500

Anytime TD

+1300

Jaylen Wright (Dolphins)

First TD

+8000

Anytime TD

+1400

Brayden Willis (49ers)

First TD

+8000

Anytime TD

+2500

James Jordan (49ers)

First TD

+10000

Anytime TD

+1600

DJ Herman (Dolphins)

First TD

+10000

Anytime TD

+3500

Justin Joly (Dolphins)

First TD

+10000

Anytime TD

+3500

Ryan Miller (Dolphins)

First TD

+10000

Anytime TD

+4000

Seydou Traore (Dolphins)

First TD

+10000

Anytime TD

+3500

KhaDarel Hodge (49ers)

First TD

+10000

Anytime TD

+5000

Receiving Yards

Mike Evans (49ers)

Over 48.5

-114

Under 48.5

-114

George Kittle (49ers)

Over 39.5

-114

Under 39.5

-114

Christian McCaffrey (49ers)

Over 38.5

-114

Under 38.5

-114

Caleb Douglas (Dolphins)

Over 38.5

-114

Under 38.5

-114

Deebo Samuel (49ers)

Over 35.5

-114

Under 35.5

-114

Malik Washington (Dolphins)

Over 34.5

-114

Under 34.5

-114

De'Von Achane (Dolphins)

Over 27.5

-114

Under 27.5

-114

Demarcus Robinson (49ers)

Over 26.5

-114

Under 26.5

-114

Chris Bell (Dolphins)

Over 19.5

-114

Under 19.5

-114

Greg Dulcich (Dolphins)

Over 19.5

-114

Under 19.5

-114

Rushing Yards

Christian McCaffrey (49ers)

Over 59.5

-114

Under 59.5

-114

De'Von Achane (Dolphins)

Over 58.5

-114

Under 58.5

-114

Malik Willis (Dolphins)

Over 38.5

-114

Under 38.5

-114

Kaelon Black (49ers)

Over 37.5

-114

Under 37.5

-114

Brock Purdy (49ers)

Over 13.5

-114

Under 13.5

-114

Deebo Samuel (49ers)

Over 5.5

-128

Under 5.5

-100

Passing Yards

Brock Purdy (49ers)

Over 238.5

-114

Under 238.5

-114

Malik Willis (Dolphins)

Over 185.5

-114

Under 185.5

-114

It’s good to consider all wagering options when it comes to NFL and micro betting can be an exciting way to get involved in the action. When everything goes in-game, consider whether a player will make or miss a field goal.

Niners Sitting on Five Wins in Previous Ten at Home

The Niners are 5-5 in their last 10 home games, averaging 22.50 points on offense and surrendering 22.90 on defense.

The Dolphins have stumbled to three consecutive losses away from home. They have gone 2-8 across their last 10 games games on the road, scoring 18.50 points per contest and conceding 26.70.

The last time the Niners faced the Dolphins at Levi's Stadium, they won 33-17.

Last 10 Games		W-L	P	PF	PA	O45.5	U45.5
49ers Home Stats		5-5	45.40	22.50	22.90	5	5
Dolphins Away Stats		2-8	45.20	18.50	26.70	4	6

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O45.5 = Games Over 45.5 Points
• U45.5 = Games Under 45.5 Points

Latest regular season and playoff games stats.

Miami Dolphins Stats

San Francisco 49ers Stats

Moneyline

• 5 wins and 5 defeats in the last 10 games
• 2 wins and 8 defeats in the last 10 games on the road

Moneyline

• 8 wins and 2 defeats in the last 10 games
• 5 wins and 5 defeats in the last 10 home games

Point Spread

• +13.5 Betting Line: Have covered the spread in 6 of the last 10 games
• +13.5 Betting Line on the Road: Have covered the spread in 6 of the last 10 games on the road

Point Spread

• -13.5 Betting Line: Have covered the spread in 4 of the last 10 games
• -13.5 Betting Line at Home: Have not covered the spread in any of the last 10 home games

Total Points

• Game Totals: An average of 42.20 pts in the previous 10 games
• Game Totals on the Road: An average of 45.20 pts in the previous 10 games on the road
• Over 45.5: Covered in 2 of the previous 10 games
• Over 45.5 on the Road: Covered in 4 of the previous 10 games on the road
• Team Totals: Have scored an average of 18.60 pts and allowed 23.60 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 18.50 pts and allowed 26.70 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 48.10 pts in the previous 10 games
• Game Totals at Home: An average of 45.40 pts in the previous 10 home games
• Over 45.5: Covered in 5 of the previous 10 games
• Over 45.5 at Home: Covered in 5 of the previous 10 home games
• Team Totals: Have scored an average of 27.30 pts and allowed 20.80 pts in the last 10 games
• Team Totals at Home: Have scored an average of 22.50 pts and allowed 22.90 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 308.10 Yds. Allowed 346.40 Yds
• Rushing Yards: Gained 133.00 Yds. Allowed 122.10 Yds
• Passing Yards: Gained 175.10 Yds. Allowed 224.30 Yds
• Total Touchdowns: Scored 1.90 TD. Allowed 3.00 TD
• Rushing Touchdowns: Scored 1.00 TD. Allowed 0.80 TD
• Passing Touchdowns: Scored 0.70 TD. Allowed 1.80 TD
• Total 1st Downs: Picked up 16.80. Allowed 20.10
• Total Turnovers: Committed 1.40. Committed by opponents 1.50
• Total Penalties: Committed 5.60. Committed by opponents 5.00
• Penalty Yards: Lost 42.90 Yds. Gained 41.00 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 338.20 Yds. Allowed 326.80 Yds
• Rushing Yards: Gained 122.00 Yds. Allowed 116.40 Yds
• Passing Yards: Gained 216.20 Yds. Allowed 210.40 Yds
• Total Touchdowns: Scored 3.20 TD. Allowed 2.50 TD
• Rushing Touchdowns: Scored 0.90 TD. Allowed 1.00 TD
• Passing Touchdowns: Scored 1.90 TD. Allowed 1.20 TD
• Total 1st Downs: Picked up 22.00. Allowed 19.00
• Total Turnovers: Committed 1.30. Committed by opponents 1.10
• Total Penalties: Committed 2.80. Committed by opponents 6.30
• Penalty Yards: Lost 25.60 Yds. Gained 44.70 Yds

Last 10 Games on the Road

• Total Yards: Gained 270.90 Yds. Allowed 328.00 Yds
• Rushing Yards: Gained 104.10 Yds. Allowed 139.20 Yds
• Passing Yards: Gained 166.80 Yds. Allowed 188.80 Yds
• Total Touchdowns: Scored 2.10 TD. Allowed 3.20 TD
• Rushing Touchdowns: Scored 0.60 TD. Allowed 1.30 TD
• Passing Touchdowns: Scored 1.40 TD. Allowed 1.30 TD
• Total 1st Downs: Picked up 16.80. Allowed 20.10
• Total Turnovers: Committed 1.70. Committed by opponents 0.90
• Total Penalties: Committed 6.30. Committed by opponents 5.40
• Penalty Yards: Lost 52.30 Yds. Gained 43.00 Yds

Last 10 Home Games

• Total Yards: Gained 356.60 Yds. Allowed 335.60 Yds
• Rushing Yards: Gained 108.00 Yds. Allowed 123.40 Yds
• Passing Yards: Gained 248.60 Yds. Allowed 212.20 Yds
• Total Touchdowns: Scored 2.60 TD. Allowed 2.60 TD
• Rushing Touchdowns: Scored 1.00 TD. Allowed 0.90 TD
• Passing Touchdowns: Scored 1.60 TD. Allowed 1.50 TD
• Total 1st Downs: Picked up 22.00. Allowed 20.00
• Total Turnovers: Committed 1.70. Committed by opponents 0.30
• Total Penalties: Committed 4.50. Committed by opponents 5.70
• Penalty Yards: Lost 37.00 Yds. Gained 41.10 Yds

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