Northwestern vs USC Prediction, Picks & Odds | 21 Jan 2026
College Basketball Betting Preview: Northwestern vs USC
The Northwestern Wildcats battle the USC Trojans, with tip-off scheduled for 23:00 on Wednesday, January 21.
It’s time to go for USC against the spread, especially with an attractive -6.5 line at -110. Our prediction is that this can be comfortably achieved in their meeting with Northwestern.
Northwestern Wildcats were beaten 77-58 in their previous game, being turned over at home to Nebraska Cornhuskers.
USC Trojans were defeated last time out. They were beaten at home to Purdue Boilmakers by a 69-64 scoreline.
Head-to-Head Statistics
The last matchup between Northwestern and USC saw the former win. It was a 77-75 scoreline.
| NCAAB | Overall | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|
USC
|
18-14 | 2515 | 2494 | 21 | 11-7 | 7-7 | 8L |
Northwestern
|
15-19 | 2487 | 2447 | 40 | 11-9 | 4-10 | 1L |
Northwestern vs USC Prediction & Picks
We’ve broken down Northwestern vs USC from every angle, offering our expert match prediction, expected final score, best player prop recommendations and a well-constructed bet builder.
Game Prediction
The best pick is to snap up the -110 that USC are able to cover the spread. The favorites are -6.5 for this college game and the margin of victory could be a good deal more significant.
To deliver the best possible basketball picks, we start by locking in the team news and taking time to review the latest form. There’s also no shortage of data to crunch from the most up-to-date college hoops stats available.
Key Northwestern vs USC stats:
USC -6.5 Probability
The latest odds at the best betting apps suggest our pick carries a 52.4% chance of winning. Based on our cappers in-depth research, we calculate the actual probability to be 55-60%. This is why we can recommend this college basketball wager.
Looking for more juice from your selection? By moving the betting line, you are able to get bigger odds although you will need to take a riskier bet.
Before your next wager, read our guide featuring today’s top betting offers, free bet deals, and sign-up bonuses.
Player Prop Picks
Nick Martinelli (Northwestern) can be wagered to total Under 25.5 points at -130. When it comes to his Player Points outcome, we are fairly confident he will total below the line.
Latest Nick Martinelli Player Prop Odds
Ezra Ausar (USC) can be backed to rack up Over 6.5 rebounds at -149. In our opinion, there is value when it comes to him covering a generous Player Rebounds line.
Latest Ezra Ausar Player Prop Odds
Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.
Same Game Parlay Picks
Try out our same game parlay pick which starts with USC -6.5. We’ve also gone for Under 150.5 and Nick Martinelli (Northwestern) to score Under 25.5 points.
A basketball same game parlay is a single event wager where you make predictions that are going to happen in a particular game. Should a bettor get these picks correct, then they can achieve a big payout from a small stake.
Correct Score Prediction
68
-
77
USC
If you want to take a chance on a correct score, then the Trojans to enjoy a 77-68 win could be along the right lines. There are enormous odds for this particular outcome.
Northwestern vs USC Odds
The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.
The sportsbooks’ betting odds have USC as -323 favorites for this college game, implying that they are 76% likely to win. The market suggests that Northwestern are least likely to win at +255.
The current spread is 6.5 and total points is 150.5. There are many ways to bet on basketball including the Totals. Those expecting a low total can back Under 150.5 at -115.
If you’re betting on college basketball, we recommend heading to the top betting sites and scanning through the wide range of team props and game lines. There’s the opportunity to wager pre-game and in-game.
Nick Martinelli is favorite when it comes to landing the most baskets. You can get -100 that he goes Over 25.5 points and -130 when it comes to Under.
Micro betting is something that’s really popular with bettors, with college basketball fans essentially being able to wager in-game when it comes to score, player and team props. Check out the two-way lines where you can bet whether the next shot will be a Two-pointer or a Three-pointer.
Latest regular season and playoff games stats.
Northwestern Stats
USC Stats
- 3 wins and 7 defeats in the last 10 games
- 4 wins and 6 defeats in the last 10 games on the road
- +6.5 Betting Line: Have covered the spread in 7 of the last 10 games
- +6.5 Betting Line on the Road: Have covered the spread in 6 of the last 10 games on the road
- -6.5 Betting Line: Have covered the spread in 5 of the last 10 games
- -6.5 Betting Line at Home: Have covered the spread in 6 of the last 10 home games
- Game Totals: An average of 146.70 pts in the previous 10 games
- Game Totals on the Road: An average of 139.20 pts in the previous 10 games on the road
- Over 152.5: Covered in 3 of the previous 10 games
- Over 152.5 on the Road: Covered in 2 of the previous 10 games on the road
- Team Totals: Have scored an average of 74.40 pts and allowed 72.30 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 69.40 pts and allowed 69.80 pts in the last 10 games on the road
- Game Totals: An average of 152.00 pts in the previous 10 games
- Game Totals at Home: An average of 164.10 pts in the previous 10 home games
- Over 152.5: Covered in 6 of the previous 10 games
- Over 152.5 at Home: Covered in 8 of the previous 10 home games
- Team Totals: Have scored an average of 77.60 pts and allowed 74.40 pts in the last 10 games
- Team Totals at Home: Have scored an average of 88.60 pts and allowed 75.50 pts in the last 10 home games
NCAAB Table Select Season
| Big Ten | Overall | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|
Michigan
|
31-3 | 2952 | 2353 | 599 | 19-2 | 12-1 | 1L |
Nebraska
|
26-6 | 2473 | 2119 | 354 | 19-3 | 7-3 | 1L |
Michigan State
|
25-7 | 2526 | 2189 | 337 | 17-3 | 8-4 | 2L |
Purdue
|
27-8 | 2858 | 2455 | 403 | 16-5 | 11-3 | 4W |
Illinois
|
24-8 | 2700 | 2234 | 466 | 15-6 | 9-2 | 1L |
Wisconsin
|
24-10 | 2822 | 2581 | 241 | 16-2 | 8-8 | 1L |
UCLA
|
23-11 | 2643 | 2414 | 229 | 18-3 | 5-8 | 1L |
Ohio State
|
21-12 | 2633 | 2402 | 231 | 15-5 | 6-7 | 1L |
Iowa
|
21-12 | 2482 | 2177 | 305 | 17-3 | 4-9 | 1L |
Indiana
|
18-14 | 2501 | 2309 | 192 | 15-6 | 3-8 | 2L |
|
USC
|
18-14 | 2515 | 2494 | 21 | 11-7 | 7-7 | 8L |
Washington
|
16-17 | 2545 | 2430 | 115 | 11-6 | 5-11 | 1L |
Minnesota
|
15-17 | 2241 | 2193 | 48 | 13-8 | 2-9 | 1L |
|
Northwestern
|
15-19 | 2487 | 2447 | 40 | 11-9 | 4-10 | 1L |
Rutgers
|
14-19 | 2329 | 2479 | -150 | 11-7 | 3-12 | 1L |
Oregon
|
12-20 | 2267 | 2366 | -99 | 10-10 | 2-10 | 1L |
Penn State
|
12-20 | 2358 | 2539 | -181 | 10-10 | 2-10 | 3L |
Maryland
|
12-21 | 2300 | 2527 | -227 | 9-8 | 3-13 | 1L |
- Overall = Overall Wins-Losses
- PF = Total Points For
- PA = Total Points Against
- N. Pts = Point Differential
- Home = Home Record
- Away = Away Record
- Strk = Current Streak
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