Clemson vs LSU Prediction, Picks & Odds | 05 Sep 2026

College Football Betting Preview: Clemson vs LSU

Clemson go up against LSU at Tiger Stadium, with kickoff scheduled for 19:30 on Saturday, September 5.

It’s all about Clemson to stay ahead of the curve against LSU. We really like this wager and the +10.5 spread looks generous at odds of -118.

Clemson Tigers lost their previous game, being beaten to Penn State Nittany Lions 22-10 at Yankee Stadium.

LSU Tigers were defeated in their last game. They suffered a 38-35 reverse against Houston Cougars at NRG Stadium.

Head-to-Head Statistics

LSU won the last matchup between the pair. Enjoying a 17-10 triumph when facing Clemson at Memorial Stadium.

Quarterbacks

Christopher Vizzina

210.5 Passing Yards

Over -114

Under -114

Sam Leavitt

264.5 Passing Yards

Over -114

Under -114

Clemson vs LSU Prediction & Picks

Discover our expert Clemson vs LSU betting tips, featuring a key match prediction, correct score suggestion, top player prop picks and bet builder advice. Scroll down for full analysis.

Game Prediction

Let’s take a chance on Clemson and wager the big underdogs with a +10.5 start. They should be able to cover the spread in this college football matchup at odds of -118.

We closely track recent form and look for patterns that may impact the outcome. The same goes for injuries to key players. When combined with the most relevant stats, this gives us a strong foundation for accurate CFB picks.

Key Clemson vs LSU stats:

• The +10.5 line has been covered by Clemson in 5 consecutive games on the road.
• The +10.5 line has been covered by Clemson in 9 of their last 10 games on the road.
• The +10.5 line has been covered by Clemson in 16 of their last 20 games on the road.
• The -10.5 line hasn’t been covered by LSU in 9 consecutive games.
• The -10.5 line hasn’t been covered by LSU in 15 of their last 20 games.

Clemson +10.5 Probability

The top betting apps make it a 54.1% chance that our pick is settled as a winner. However, our cappers have this figure closer to 60% based on their in-depth research. This is why we regard this as a value wager.

If you want to land a big potential return from a small stake, then a Bet Builder could be a way to go. Bet on Clemson to cover the line in a combination with other selections.

Check out the most rewarding betting offers in our in-depth guide before your next wager. The best bonuses and free bets await.

Our Game Prediction

Clemson +10.5 @ -118 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Sep 4, 02:25). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Christopher Vizzina Over 210.5 Passing Yards -114

Christopher Vizzina (Clemson) can be backed at -114 to go over 210.5 passing yards. The line for QB Passing Yards looks attractive and we’re confident of securing a return.

Latest Christopher Vizzina Player Prop Odds

Passing Yards

Over 210.5

-114

Under 210.5

-114

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Jayce Brown Over 47.5 Receiving Yards -114

You can back Jayce Brown (Clemson) at -114 surpass 47.5 receiving yards. The line for him on the Overs is highly appealing, with Player Receiving Yards bettors able to get plenty of juice.

Latest Jayce Brown Player Prop Odds

Receiving Yards

Over 47.5

-114

Under 47.5

-114

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Clemson 20 - 23 LSU

We’re expecting a close battle so it might be worth going for LSU to triumph by a 23-20 scoreline. You can get a massive price and we should hopefully get a run for our money.

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Clemson vs LSU Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

LSU have short betting odds and they’re overwhelming -385 favorites for this college game. This means the sportsbooks give them a 79% chance of winning. For those wanting to oppose the market leader, you can get +310 about Clemson.

The spread is calculated to be 10.5, while total points comes in at 50.5. A Total bet relates to the number of points that will be scored overall. Those who wager Under 50.5 can get -105.

You can find a wide range of team props and game lines for every college football matchup, with the best sportsbooks creating lots of different options. Explore the pre-game and in-game selections before placing your wagers.

Moneyline

Clemson

+310

LSU

-385

Point Spread

Clemson +10.5

-118

LSU -10.5

-104

Total Points

Under 50.5

-105

Over 50.5

-115

Receiving Yards

Bryant Wesco Jr. (Clemson)

Over 51.5

-114

Under 51.5

-114

Jayce Brown (LSU)

Over 47.5

-114

Under 47.5

-114

Trey'Dez Green (LSU)

Over 46.5

-114

Under 46.5

-114

T.J. Moore (Clemson)

Over 43.5

-114

Under 43.5

-114

Jackson Harris (LSU)

Over 42.5

-114

Under 42.5

-114

Eugene Wilson III (LSU)

Over 28.5

-114

Under 28.5

-114

Rushing Yards

Dilin Jones (LSU)

Over 51.5

-114

Under 51.5

-114

Gideon Davidson (Clemson)

Over 44.5

-114

Under 44.5

-114

Sam Leavitt (LSU)

Over 25.5

-114

Under 25.5

-114

Passing Yards

Sam Leavitt (LSU)

Over 264.5

-114

Under 264.5

-114

Christopher Vizzina (Clemson)

Over 210.5

-114

Under 210.5

-114

LSU Sitting on Eight Wins in Past Ten at Home

LSU own a 8-2 mark in their past 10 home games, scoring 25.40 points per contest and conceding 19.40.

Clemson have built a run of four straight road victories. They own a 8-2 mark in their past 10 road games, putting up 30.30 points on average and giving up 19.40.

The last time these teams met at Tiger Stadium, LSU came out on top 42-25 against Clemson.

Last 10 Games		W-L	P	PF	PA	O50.5	U50.5
LSU Home Stats		8-2	44.80	25.40	19.40	4	6
Clemson Away Stats		8-2	49.70	30.30	19.40	4	6

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O50.5 = Games Over 50.5 Points
• U50.5 = Games Under 50.5 Points

Latest regular season and playoff games stats.

Clemson Tigers Stats

LSU Tigers Stats

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 8 wins and 2 defeats in the last 10 games on the road

Moneyline

• 4 wins and 6 defeats in the last 10 games
• 9 wins and 1 defeat in the last 10 home games

Point Spread

• +10.5 Betting Line: Have covered the spread in 7 of the last 10 games
• +10.5 Betting Line on the Road: Have covered the spread in 9 of the last 10 games on the road

Point Spread

• -10.5 Betting Line: Have covered the spread in 1 of the last 10 games
• -10.5 Betting Line at Home: Have covered the spread in 4 of the last 10 home games

Total Points

• Game Totals: An average of 50.60 pts in the previous 10 games
• Game Totals on the Road: An average of 49.70 pts in the previous 10 games on the road
• Over 50.5: Covered in 5 of the previous 10 games
• Over 50.5 on the Road: Covered in 4 of the previous 10 games on the road
• Team Totals: Have scored an average of 29.60 pts and allowed 21.00 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 30.30 pts and allowed 19.40 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 46.80 pts in the previous 10 games
• Game Totals at Home: An average of 46.80 pts in the previous 10 home games
• Over 50.5: Covered in 4 of the previous 10 games
• Over 50.5 at Home: Covered in 4 of the previous 10 home games
• Team Totals: Have scored an average of 23.70 pts and allowed 23.10 pts in the last 10 games
• Team Totals at Home: Have scored an average of 28.50 pts and allowed 18.30 pts in the last 10 home games

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