LSU vs Ole Miss Prediction, Picks & Odds | 19 Sep 2026

College Football Betting Preview: LSU vs Ole Miss

LSU battle Ole Miss at Vaught-Hemingway Stadium, with kickoff scheduled for 19:30 on Saturday, September 19.

We’ve lined up a prediction which requires Ole Miss to keep close to LSU. We think that the line of +2.5 can be covered and you can secure -102.

LSU Tigers have won their previous two games. The latest was a 45-14 home triumph at Tiger Stadium against Louisiana Tech Bulldogs.

Ole Miss Rebels won their last game 41-9, making it successive victories. This was a home win at Vaught-Hemingway Stadium against Charlotte 49ers.

Head-to-Head Statistics

Ole Miss beat LSU in their last head-to-head matchup. It was a 24-19 scoreline at Vaught-Hemingway Stadium. LSU have won four of the past 7 games that these teams have played.

Quarterbacks

Sam Leavitt

271.5 Passing Yards

Over -114

Under -114

Trinidad Chambliss

277.5 Passing Yards

Over -114

Under -114

LSU vs Ole Miss Prediction & Picks

The LSU vs Ole Miss betting tips feature sharp analysis across major markets, including a key match prediction, player prop bets, correct score guidance and a ready-made bet builder.

Game Prediction

Ole Miss look easy to back at -102 considering they’ve been given a spread of +2.5. This looks a good number when squaring off in this college football battle.

Our expert CFB handicappers study recent form and take injuries into account when assessing each matchup. Before delivering a verdict, we combine that insight with the latest stats to strengthen our analysis.

Key LSU vs Ole Miss stats:

• The +2.5 line has been covered by Ole Miss in 9 of their last 10 games.
• The +2.5 line has been covered by Ole Miss in 18 of their last 20 games at home.
• The +2.5 line has been covered by Ole Miss in 2 consecutive games.
• The -2.5 line hasn’t been covered by LSU in 5 consecutive games on the road.
• The -2.5 line hasn’t been covered by LSU in 7 of their last 10 games on the road.
• The -2.5 line hasn’t been covered by LSU in 12 of their last 20 games on the road.

Ole Miss +2.5 Probability

The top sportsbooks imply that our pick has a 50.5% prospect of winning. However, we think that the probability is close to 60% taking all factors into consideration. It is the reason why we are recommending this college wager.

The sportsbooks give you the chance to buy or sell points, meaning that you can select from a variety of lines. Buying means shorter prices, with selling sending the odds upwards.

Get more from your bets with our detailed guide, featuring the best free bets and generous welcome bonuses.

Our Game Prediction

Ole Miss +2.5 @ -102 Bet Now

BetMGM Promo Up To $1500 in Bonus Bets Get Bonus T&C apply. Gamble responsibly 18+

Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Sep 18, 02:25). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Trinidad Chambliss Over 277.5 Passing Yards -114

Trinidad Chambliss (Ole Miss) is priced at -114 to reach over 277.5 passing yards. We’re confident in taking him to cover the QB Passing Yards line and bettors can back this pick with conviction.

Latest Trinidad Chambliss Player Prop Odds

Passing Yards

Over 277.5

-114

Under 277.5

-114

Rushing Yards

Over 37.5

-114

Under 37.5

-114

---

Sam Leavitt Over 43.5 Rushing Yards -114

The odds for Sam Leavitt (LSU) to go beyond 43.5 rushing yards are -114. With confidence, we can back him to cover the generous Player Rushing Yards line, as all the signs point to him reaching the expected total.

Latest Sam Leavitt Player Prop Odds

Passing Yards

Over 271.5

-114

Under 271.5

-114

Rushing Yards

Over 43.5

-114

Under 43.5

-114

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

LSU 24 - 28 Ole Miss

There might not be too much between these teams, with our correct score pick being a 28-24 victory for the Rebels. There are huge odds available when it comes to this prediction.

T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

LSU vs Ole Miss Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

For this college game, the sportsbooks’ Moneyline betting odds mean LSU are -145 favorites to win and that means a 59% chance of landing a victory. For those wanting to oppose the market leader, you can get +122 about Ole Miss.

The spread is 2.5 and the total points line is currently 58.5. A Total wager is always available and can often provide value selections. If you’re going for Under 58.5, this outcome can be backed at -110.

Whether you are wagering pre-game or in-game on college football, the top betting apps let you feast on a wide range of team props and game lines. The selections are practically endless, and it’s awesome to have so many options at your fingertips.

Moneyline

LSU

-145

Ole Miss

+122

Point Spread

LSU -2.5

-120

Ole Miss +2.5

-102

Total Points

Under 58.5

-110

Over 58.5

-110

Receiving Yards

Deuce Alexander (Ole Miss)

Over 71.5

-114

Under 71.5

-114

Trey'Dez Green (LSU)

Over 60.5

-112

Under 60.5

-118

Horatio Fields (Ole Miss)

Over 43.5

-114

Under 43.5

-114

Eugene Wilson III (LSU)

Over 42.5

-114

Under 42.5

-114

Caleb Odom (Ole Miss)

Over 26.5

-114

Under 26.5

-114

Jackson Harris (LSU)

Over 24.5

-114

Under 24.5

-114

Kewan Lacy (Ole Miss)

Over 18.5

-114

Under 18.5

-114

Rushing Yards

Kewan Lacy (Ole Miss)

Over 84.5

-114

Under 84.5

-114

Dilin Jones (LSU)

Over 78.5

-114

Under 78.5

-114

Sam Leavitt (LSU)

Over 43.5

-114

Under 43.5

-114

Trinidad Chambliss (Ole Miss)

Over 37.5

-114

Under 37.5

-114

Passing Yards

Trinidad Chambliss (Ole Miss)

Over 277.5

-114

Under 277.5

-114

Sam Leavitt (LSU)

Over 271.5

-114

Under 271.5

-114

Ole Miss Tough to Crack at Home

Ole Miss have a 10-0 record in their last 10 home games, putting up 39.20 points on average and giving up 14.90.

LSU have dropped five road games in a row. They have gone 3-7 across their last 10 games away from home, averaging 22.60 points on offense and surrendering 24.80 on defense.

Ole Miss beat LSU 24-19 when they last met at Vaught-Hemingway Stadium. Looking at the last 4 head-to-heads at Vaught-Hemingway Stadium, Ole Miss have tallied three victories, with LSU winning once.

Last 10 Games		W-L	P	PF	PA	O58.5	U58.5
Ole Miss Home Stats		10-0	54.10	39.20	14.90	2	8
LSU Away Stats		3-7	47.40	22.60	24.80	3	7

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O58.5 = Games Over 58.5 Points
• U58.5 = Games Under 58.5 Points

Latest regular season and playoff games stats.

LSU Tigers Stats

Ole Miss Stats

Moneyline

• 5 wins and 5 defeats in the last 10 games
• 3 wins and 7 defeats in the last 10 games on the road

Moneyline

• 9 wins and 1 defeat in the last 10 games
• 9 wins and 1 defeat in the last 10 home games

Point Spread

• -2.5 Betting Line: Have covered the spread in 4 of the last 10 games
• -2.5 Betting Line on the Road: Have covered the spread in 3 of the last 10 games on the road

Point Spread

• +2.5 Betting Line: Have covered the spread in 9 of the last 10 games
• +2.5 Betting Line at Home: Have covered the spread in 9 of the last 10 home games

Total Points

• Game Totals: An average of 47.90 pts in the previous 10 games
• Game Totals on the Road: An average of 47.40 pts in the previous 10 games on the road
• Over 58.5: Covered in 4 of the previous 10 games
• Over 58.5 on the Road: Covered in 3 of the previous 10 games on the road
• Team Totals: Have scored an average of 25.80 pts and allowed 22.10 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 22.60 pts and allowed 24.80 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 57.90 pts in the previous 10 games
• Game Totals at Home: An average of 53.20 pts in the previous 10 home games
• Over 58.5: Covered in 3 of the previous 10 games
• Over 58.5 at Home: Covered in 1 of the previous 10 home games
• Team Totals: Have scored an average of 37.40 pts and allowed 20.50 pts in the last 10 games
• Team Totals at Home: Have scored an average of 35.60 pts and allowed 17.60 pts in the last 10 home games

Where to Bet on American Football Games

Top American Football Pages