Michigan State vs Notre Dame Prediction, Picks & Odds | 19 Sep 2026

College Football Betting Preview: Michigan State vs Notre Dame

Michigan State face Notre Dame at Notre Dame Stadium, with kickoff scheduled for 19:30 on Saturday, September 19.

We have decided to go for Notre Dame against the spread in order to get the best value. The Irish should be able to cover the -29.5 line at odds of -110 when they take on Michigan State.

Notre Dame and Michigan State renew one of the Midwest's traditional rivalries under the lights. The battle for the Megaphone Trophy adds some old-school rivalry flavor to one of Saturday night's most intriguing matchups.

Michigan State has opened the season 2-0 with a pair of home victories. The Spartans began with a 30-20 win over Toledo before comfortably beating Eastern Michigan 35-7 last time out, scoring 21 unanswered points in the second half.

Notre Dame has also made a perfect 2-0 start, beginning with a 41-13 home victory over Wisconsin. The Irish followed up with an emphatic 52-0 win against Rice at Notre Dame Stadium last time out.

Quarterbacks

Alessio Milivojevic

170.5 Passing Yards

Over -112

Under -112

CJ Carr

253.5 Passing Yards

Over -112

Under -112

Michigan State vs Notre Dame Prediction & Picks

Our Michigan State vs Notre Dame tips include the main match prediction, a correct score forecast, bet builder advice and top player prop picks. Each section below offers expert insight into the key betting angles.

Game Prediction

There’s a case to be made for Notre Dame on the spread in this college football showdown. Our prediction is that the betting favorites can cover the -29.5 line at odds of -110 considering they should be superior.

Knowing which players are injured gives us a valuable edge when making college football predictions. After reviewing the form guide, we turn to the latest stats to shape our picks.

Key Michigan State vs Notre Dame stats:

• The -29.5 line has been covered by Notre Dame in 3 of their last 5 games at home.
• Notre Dame has won 7 consecutive games at Notre Dame Stadium.
• MSU has suffered 9 straight defeats on the road.

Notre Dame -29.5 Probability

When you look at the latest odds, our pick has a 52.4% chance of delivering a return. In the opinion of our cappers, there’s actually a probability of success between 55-60%. This is why we regard this as a value bet.

There’s regularly the option to sell points and that allows you to leverage a bigger potential return. Conversely, buying points will give you a less-risky wager but shorter odds.

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Our Game Prediction

Notre Dame -29.5 @ -110 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Sep 18, 02:25). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Alessio Milivojevic Under 149.5 Passing Yards -114

You can back Alessio Milivojevic (Michigan State) at -114 to end with fewer than 149.5 passing yards. There’s a strong case for choosing him to fall short of the required line in the QB Passing Yards market.

Latest Alessio Milivojevic Player Prop Odds

Passing Yards

Over 170.5

-112

Under 170.5

-112

---

Cooper Flanagan Under 17.5 Receiving Yards -114

Cooper Flanagan (Michigan State) can be backed at -114 to have less than 17.5 receiving yards. There’s no reason to doubt our instinct, so we’ll bet on him falling short of the Player Receiving Yards line.

Latest Cooper Flanagan Player Prop Odds

Receiving Yards

Over 15.5

-110

Under 15.5

-116

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Michigan State 14 - 45 Notre Dame

There is a speculative bet that can be enjoyed on the Irish when it comes to the correct score lines. Taking them to win 45-14 should provide some entertainment.

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Michigan State vs Notre Dame Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

You might not get rich backing Notre Dame at -10000. However, the sportsbooks’ betting odds imply a 99% chance of winning this college game. If you’re looking for an alternative angle, Michigan State are trading at +2000.

There is a spread of 29.5 and total points has a line of 52.5. Having a bet on the Totals is one of the most popular football wagers. Those expecting a low total can back Under 52.5 at -115.

College football bettors are spoilt for choice thanks to the huge selection of team props and game lines which are available for every matchup on the coupon. Head to the top sportsbooks and find the best value wagers.

Moneyline

MSU

+2000

Notre Dame

-10000

Point Spread

MSU +29.5

-114

Notre Dame -29.5

-106

Total Points

Under 52.5

-115

Over 52.5

-105

Receiving Yards

Jordan Faison (Notre Dame)

Over 67.5

-112

Under 67.5

-112

Rodney Bullard Jr. (MSU)

Over 37.5

-112

Under 37.5

-112

Chrishon McCray (MSU)

Over 33.5

-112

Under 33.5

-112

Micah Gilbert (Notre Dame)

Over 28.5

-112

Under 28.5

-112

Cooper Flanagan (Notre Dame)

Over 15.5

-110

Under 15.5

-116

Aneyas Williams (Notre Dame)

Over 10.5

-112

Under 10.5

-112

Rushing Yards

Aneyas Williams (Notre Dame)

Over 88.5

-112

Under 88.5

-112

Cam Edwards (MSU)

Over 49.5

-112

Under 49.5

-112

Passing Yards

CJ Carr (Notre Dame)

Over 253.5

-112

Under 253.5

-112

Alessio Milivojevic (MSU)

Over 170.5

-112

Under 170.5

-112

Notre Dame Keep Cashing In at Home

Notre Dame has put together seven straight wins at Notre Dame Stadium. The Irish have gone 9-1 across their last 10 home games, averaging 44.10 points on offense and surrendering 15.70 on defense.

Michigan State has been beaten nine consecutive times away from home. The Spartans are 1-9 in their last 10 road games, averaging 19.70 points scored and 30.40 points allowed.

Last 10 Games		W-L	P	PF	PA	O52.5	U52.5
Notre Dame Home Stats		9-1	59.80	44.10	15.70	6	4
Michigan State Away Stats		1-9	50.10	19.70	30.40	3	7

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O52.5 = Games Over 52.5 Points
• U52.5 = Games Under 52.5 Points

Latest regular season and playoff games stats.

Michigan State Spartans Stats

Notre Dame Fighting Irish Stats

Moneyline

• 3 wins and 7 defeats in the last 10 games
• 1 win and 9 defeats in the last 10 games on the road

Moneyline

• 10 wins and 0 defeats in the last 10 games
• 8 wins and 2 defeats in the last 10 home games

Point Spread

• +29.5 Betting Line: Have covered the spread in the last 10 games
• +29.5 Betting Line on the Road: Have covered the spread in the last 10 games on the road

Point Spread

• -29.5 Betting Line: Have covered the spread in 3 of the last 10 games
• -29.5 Betting Line at Home: Have covered the spread in 3 of the last 10 home games

Total Points

• Game Totals: An average of 49.40 pts in the previous 10 games
• Game Totals on the Road: An average of 50.10 pts in the previous 10 games on the road
• Over 52.5: Covered in 2 of the previous 10 games
• Over 52.5 on the Road: Covered in 3 of the previous 10 games on the road
• Team Totals: Have scored an average of 22.30 pts and allowed 27.10 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 19.70 pts and allowed 30.40 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 53.40 pts in the previous 10 games
• Game Totals at Home: An average of 60.20 pts in the previous 10 home games
• Over 52.5: Covered in 5 of the previous 10 games
• Over 52.5 at Home: Covered in 7 of the previous 10 home games
• Team Totals: Have scored an average of 42.10 pts and allowed 11.30 pts in the last 10 games
• Team Totals at Home: Have scored an average of 42.90 pts and allowed 17.30 pts in the last 10 home games

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