Michigan State vs Notre Dame Prediction, Picks & Odds | 19 Sep 2026
College Football Betting Preview: Michigan State vs Notre Dame
Michigan State face Notre Dame at Notre Dame Stadium, with kickoff scheduled for 19:30 on Saturday, September 19.
We have decided to go for Notre Dame against the spread in order to get the best value. They should be able to cover the -29.5 line at odds of -110 when they take on Michigan State.
Michigan State Spartans made it back-to-back wins after a 35-7 home success over Eastern Michigan Eagles at Spartan Stadium.
Notre Dame Fighting Irish last game was a 52-0 home win. This victory over Rice Owls at Notre Dame Stadium made it back-to-back victories.
Quarterbacks
Alessio Milivojevic
CJ Carr
Michigan State vs Notre Dame Prediction & Picks
Our Michigan State vs Notre Dame tips include the main match prediction, a correct score forecast, bet builder advice and top player prop picks. Each section below offers expert insight into the key betting angles.
Game Prediction
There’s a case to be made for Notre Dame on the spread in this college football showdown. Our prediction is that the betting favorites can cover the -29.5 line at odds of -110 considering they should be superior.
Knowing which players are injured gives us a valuable edge when making college football predictions. After reviewing the form guide, we turn to the latest stats to shape our picks.
Key Michigan State vs Notre Dame stats:
Notre Dame -29.5 Probability
When you look at the latest odds, our pick has a 52.4% chance of delivering a return. In the opinion of our cappers, there’s actually a probability of success between 55-60%. This is why we regard this as a value bet.
There’s regularly the option to sell points and that allows you to leverage a bigger potential return. Conversely, buying points will give you a less-risky wager but shorter odds.
Get more from your bets—review the most up-to-date betting promo codes and sign-up offers in our exclusive bonus guide.
Player Prop Picks
You can back Alessio Milivojevic (Michigan State) at -114 to end with fewer than 149.5 passing yards. There’s a strong case for choosing him to fall short of the required line in the QB Passing Yards market.
Cooper Flanagan (Michigan State) can be backed at -114 to have less than 17.5 receiving yards. There’s no reason to doubt our instinct, so we’ll bet on him falling short of the Player Receiving Yards line.
Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.
Same Game Parlay Picks
We’ve loaded up a same game parlay with the combined picks of Notre Dame -29.5, Over 52.5 and Alessio Milivojevic (Michigan State) to go Under 149.5 passing yards.
A football same game parlay is a single event wager where you make predictions that are going to happen in a particular game. Should a bettor get these picks correct, then they can achieve a big return from a small stake.
Correct Score Prediction
14
-
45
Notre Dame
There is a speculative bet that can be enjoyed on the Irish when it comes to the correct score lines. Taking them to win 45-14 should provide some entertainment.
Michigan State vs Notre Dame Odds
The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.
You might not get rich backing Notre Dame at -10000. However, the sportsbooks’ betting odds imply a 99% chance of winning this college game. If you’re looking for an alternative angle, Michigan State are trading at +2400.
There is a spread of 29.5 and total points has a line of 52.5. Having a bet on the Totals is one of the most popular football wagers. Those expecting a low total can back Under 52.5 at -115.
College football bettors are spoilt for choice thanks to the huge selection of team props and game lines which are available for every matchup on the coupon. Head to the top sportsbooks and find the best value wagers.
Receiving Yards
Rushing Yards
Passing Yards
Notre Dame Keep Cashing In at Home
Notre Dame have put together seven straight wins at Notre Dame Stadium. They have gone 9-1 across their last 10 home games, averaging 44.10 points on offense and surrendering 15.70 on defense.
Michigan State have been beaten nine consecutive times away from home. They are 1-9 in their last 10 road games, averaging 19.70 points scored and 30.40 points allowed.
| Last 10 Games | W-L | P | PF | PA | O52.5 | U52.5 | |
|---|---|---|---|---|---|---|---|
 Notre Dame Home Stats |
9-1 | 59.80 | 44.10 | 15.70 | 6 | 4 | |
 Michigan State Away Stats |
1-9 | 50.10 | 19.70 | 30.40 | 3 | 7 | |
- W-L = Wins-Losses
- P = Avg. Points
- PF = Avg. Points For
- PA = Avg. Points Against
- O52.5 = Games Over 52.5 Points
- U52.5 = Games Under 52.5 Points
Latest regular season and playoff games stats.
Michigan State Spartans Stats
Notre Dame Fighting Irish Stats
- 3 wins and 7 defeats in the last 10 games
- 1 win and 9 defeats in the last 10 games on the road
- +29.5 Betting Line: Have covered the spread in the last 10 games
- +29.5 Betting Line on the Road: Have covered the spread in the last 10 games on the road
- -29.5 Betting Line: Have covered the spread in 3 of the last 10 games
- -29.5 Betting Line at Home: Have covered the spread in 3 of the last 10 home games
- Game Totals: An average of 49.40 pts in the previous 10 games
- Game Totals on the Road: An average of 50.10 pts in the previous 10 games on the road
- Over 52.5: Covered in 2 of the previous 10 games
- Over 52.5 on the Road: Covered in 3 of the previous 10 games on the road
- Team Totals: Have scored an average of 22.30 pts and allowed 27.10 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 19.70 pts and allowed 30.40 pts in the last 10 games on the road
- Game Totals: An average of 53.40 pts in the previous 10 games
- Game Totals at Home: An average of 60.20 pts in the previous 10 home games
- Over 52.5: Covered in 5 of the previous 10 games
- Over 52.5 at Home: Covered in 7 of the previous 10 home games
- Team Totals: Have scored an average of 42.10 pts and allowed 11.30 pts in the last 10 games
- Team Totals at Home: Have scored an average of 42.90 pts and allowed 17.30 pts in the last 10 home games
| Independents I-A | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
|
Notre Dame
|
2 | 0 | 93 | 13 | 80 | 2-0 | 0-0 | 2W |
UConn
|
1 | 1 | 70 | 45 | 25 | 1-1 | 0-0 | 1L |
| Big Ten | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
Indiana
|
2 | 0 | 107 | 16 | 91 | 2-0 | 0-0 | 2W |
Washington
|
2 | 0 | 40 | 24 | 16 | 2-0 | 0-0 | 2W |
Wisconsin
|
1 | 1 | 49 | 50 | -1 | 1-0 | 0-1 | 1W |
Purdue
|
1 | 1 | 80 | 57 | 23 | 1-1 | 0-0 | 1L |
Oregon
|
1 | 1 | 65 | 66 | -1 | 1-0 | 0-1 | 1L |
Ohio State
|
1 | 1 | 79 | 27 | 52 | 1-0 | 0-1 | 1L |
Minnesota
|
1 | 1 | 72 | 45 | 27 | 1-1 | 0-0 | 1L |
Illinois
|
1 | 1 | 69 | 54 | 15 | 1-1 | 0-0 | 1L |
USC
|
3 | 0 | 130 | 56 | 74 | 3-0 | 0-0 | 3W |
Iowa
|
2 | 0 | 56 | 13 | 43 | 2-0 | 0-0 | 2W |
UCLA
|
2 | 0 | 73 | 34 | 39 | 1-0 | 1-0 | 2W |
Penn State
|
2 | 0 | 72 | 9 | 63 | 1-0 | 1-0 | 2W |
Northwestern
|
1 | 0 | 34 | 18 | 16 | 1-0 | 0-0 | 1W |
Nebraska
|
2 | 0 | 105 | 28 | 77 | 2-0 | 0-0 | 2W |
Michigan
|
2 | 0 | 30 | 22 | 8 | 2-0 | 0-0 | 2W |
|
Michigan State
|
2 | 0 | 65 | 27 | 38 | 2-0 | 0-0 | 2W |
Maryland
|
2 | 0 | 100 | 14 | 86 | 1-0 | 1-0 | 2W |
Rutgers
|
0 | 2 | 42 | 65 | -23 | 0-1 | 0-1 | 2L |
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