Mississippi State vs South Carolina Prediction, Picks & Odds | 19 Sep 2026

College Football Betting Preview: Mississippi State vs South Carolina

Mississippi State face South Carolina at Williams-Brice Stadium, with kickoff scheduled for 16:15 on Saturday, September 19.

It’s great to see South Carolina with a -3.5 line on the spread at -115 as we’re expecting a bigger margin of victory when playing Mississippi State.

Mississippi State Bulldogs have won two on the spin, triumphing 38-13 in their previous game. This was on the road against Minnesota Golden Gophers at Huntington Bank Stadium.

South Carolina Gamecocks last game was a 45-9 home win. This victory over Towson Tigers at Williams-Brice Stadium made it back-to-back victories.

Head-to-Head Statistics

It was South Carolina who came out on top when they last played Mississippi State. At Williams-Brice Stadium, a 37-30 win was recorded.

Quarterbacks

Kamario Taylor

244.5 Passing Yards

Over -114

Under -114

LaNorris Sellers

239.5 Passing Yards

Over -114

Under -114

Mississippi State vs South Carolina Prediction & Picks

We dive into the best Mississippi State vs South Carolina betting angles, including an expert match prediction, correct score forecast, top player prop bets and a value-focused bet builder.

Game Prediction

It’s time to go for South Carolina against the spread, especially with an attractive -3.5 line at -115. Our pick is that the favorites can achieve a comfortable win in this college football battle.

Team news plays a key role in our college football forecasts and we’re always tracking players with injury concerns. We also stay on top of the form guide, supported by detailed stats that help paint a clearer picture of what to expect

Key Mississippi State vs South Carolina stats:

• The -3.5 line has been covered by South Carolina in 6 of their last 10 games at home.
• The -3.5 line has been covered by South Carolina in 3 of their last 5 games.
• The -3.5 line has been covered by South Carolina in 2 consecutive games.
• The +3.5 line hasn’t been covered by Mississippi State in 13 of their last 20 games on the road.
• The +3.5 line hasn’t been covered by Mississippi State in 6 of their last 10 games.

South Carolina -3.5 Probability

According to the latest betting odds, our pick has a 53.5% chance of winning. Our experts think there’s a stronger chance of success and calculate the probability to be closer to 60%. This college wager can therefore be backed with confidence.

If the initial odds don’t grab your fancy, there’s the option to shoot for more juice by moving the line when it comes to your spread pick. It all comes down to how confident you feel.

Before placing your bets, take advantage of our guide packed with up-to-date free bets and the latest bonus offers.

Our Game Prediction

South Carolina -3.5 @ -115 Bet Now

BetMGM Promo Up To $1500 in Bonus Bets Get Bonus T&C apply. Gamble responsibly 18+

Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Sep 17, 22:26). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: LaNorris Sellers Over 239.5 Passing Yards -114

LaNorris Sellers (South Carolina) is priced at -114 to rack up over 239.5 passing yards. We’re tempted to back him to cover the QB Passing Yards line, with plenty of juice on offer.

Latest LaNorris Sellers Player Prop Odds

Passing Yards

Over 239.5

-114

Under 239.5

-114

Rushing Yards

Over 38.5

-114

Under 38.5

-114

---

Nyck Harbor Over 59.5 Receiving Yards -114

Nyck Harbor (South Carolina) can be backed at -114 to record more than 59.5 receiving yards. We believe it makes sense to stick with him on the Over and bettors can be confident in this Player Receiving Yards pick.

Latest Nyck Harbor Player Prop Odds

Receiving Yards

Over 59.5

-114

Under 59.5

-114

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

MS State 21 - 28 South Carolina

There are lots of different betting angles including the chance to bet on the Gamecocks on the correct score lines. For example, a 28-21 win in their favor is available at huge odds.

T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Mississippi State vs South Carolina Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

For this college game, the sportsbooks’ Moneyline betting odds mean South Carolina are -182 favorites to win and that means a 65% chance of landing a victory. If you’re looking for an alternative angle, Mississippi State are trading at +150.

There is a spread of 3.5 and total points has a line of 58.5. Having a bet on the Totals is one of the most popular football wagers. If you fancy Under 58.5, then the odds are -110.

You can find a nice selection of game lines and team props for every college football game, with the top betting apps creating many different options. Check out the pre-game and in-game selections before placing your bets.

Moneyline

MS State

+150

South Carolina

-182

Point Spread

MS State +3.5

-105

South Carolina -3.5

-115

Total Points

Under 58.5

-110

Over 58.5

-110

Receiving Yards

Anthony Evans III (MS State)

Over 82.5

-114

Under 82.5

-114

Nyck Harbor (South Carolina)

Over 59.5

-114

Under 59.5

-114

Mazeo Bennett Jr. (South Carolina)

Over 36.5

-114

Under 36.5

-114

Zion Ragins (MS State)

Over 36.5

-114

Under 36.5

-114

Brady Hunt (South Carolina)

Over 19.5

-114

Under 19.5

-114

Fluff Bothwell (MS State)

Over 14.5

-114

Under 14.5

-114

Rushing Yards

Fluff Bothwell (MS State)

Over 69.5

-114

Under 69.5

-114

Matt Fuller (South Carolina)

Over 54.5

-114

Under 54.5

-114

Kamario Taylor (MS State)

Over 48.5

-112

Under 48.5

-118

LaNorris Sellers (South Carolina)

Over 38.5

-114

Under 38.5

-114

Passing Yards

Kamario Taylor (MS State)

Over 244.5

-114

Under 244.5

-114

LaNorris Sellers (South Carolina)

Over 239.5

-114

Under 239.5

-114

South Carolina Own Six Victories From Previous Ten at Home

South Carolina have gone 6-4 across their last 10 home games, posting 33.20 points per contest while yielding 16.50.

Mississippi State have a 3-7 record in their last 10 road games, scoring 23.90 points per contest and conceding 30.30.

The most recent Williams-Brice Stadium meeting saw South Carolina claim a 37-30 win over Mississippi State.

Last 10 Games		W-L	P	PF	PA	O58.5	U58.5
South Carolina Home Stats		6-4	49.70	33.20	16.50	1	9
Mississippi State Away Stats		3-7	54.20	23.90	30.30	3	7

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O58.5 = Games Over 58.5 Points
• U58.5 = Games Under 58.5 Points

Latest regular season and playoff games stats.

Mississippi State Bulldogs Stats

South Carolina Gamecocks Stats

Moneyline

• 3 wins and 7 defeats in the last 10 games
• 3 wins and 7 defeats in the last 10 games on the road

Moneyline

• 4 wins and 6 defeats in the last 10 games
• 6 wins and 4 defeats in the last 10 home games

Point Spread

• +3.5 Betting Line: Have covered the spread in 4 of the last 10 games
• +3.5 Betting Line on the Road: Have covered the spread in 4 of the last 10 games on the road

Point Spread

• -3.5 Betting Line: Have covered the spread in 4 of the last 10 games
• -3.5 Betting Line at Home: Have covered the spread in 6 of the last 10 home games

Total Points

• Game Totals: An average of 63.30 pts in the previous 10 games
• Game Totals on the Road: An average of 54.20 pts in the previous 10 games on the road
• Over 58.5: Covered in 6 of the previous 10 games
• Over 58.5 on the Road: Covered in 3 of the previous 10 games on the road
• Team Totals: Have scored an average of 30.20 pts and allowed 33.10 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 23.90 pts and allowed 30.30 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 47.80 pts in the previous 10 games
• Game Totals at Home: An average of 46.40 pts in the previous 10 home games
• Over 58.5: Covered in 1 of the previous 10 games
• Over 58.5 at Home: Has not been covered in any of the previous 10 home games
• Team Totals: Have scored an average of 28.50 pts and allowed 19.30 pts in the last 10 games
• Team Totals at Home: Have scored an average of 30.00 pts and allowed 16.40 pts in the last 10 home games

Where to Bet on American Football Games

Top American Football Pages