SMU vs Louisville Prediction, Picks & Odds | 19 Sep 2026
College Football Betting Preview: SMU vs Louisville
SMU battle Louisville at L&N Federal Credit Union Stadium, with kickoff scheduled for 15:30 on Saturday, September 19.
The -115 about Under 59.5 points makes lots of appeal and represents value in our eyes. We’re not sure that Louisville and SMU can combine to reach that total.
SMU Mustangs made it back-to-back wins after a 56-10 home success over California-Davis Aggies at Gerald J. Ford Stadium.
Louisville Cardinals were winners last time out. It was a 59-13 home victory against Villanova at L&N Federal Credit Union Stadium.
Head-to-Head Statistics
SMU beat Louisville when the teams last met. It was a 38-6 scoreline at Gerald J. Ford Stadium.
Quarterbacks
Kevin Jennings
Lincoln Kienholz
SMU vs Louisville Prediction & Picks
Take in the full SMU vs Louisville betting outlook — from our expert match prediction and correct score pick to player prop insights and a bet builder tailored for value.
Game Prediction
In our opinion, the teams are unlikely to reach the 59.5 points line. Therefore, chance an Under bet at -115 and hope the number isn’t reached in this college football showdown.
The CFB handicappers at Sportsgambler.com stay on top of injuries and team form that could impact the outcome. We also leave no stone unturned when analyzing the latest stats to support every prediction.
Key SMU vs Louisville stats:
Under 59.5 Probability
Based on the odds from the top betting apps, our pick has a 53.5% chance of landing a return. However, our cappers research has found that the actual probability is closer to 60%. The bet can be recommended for this precise reason.
More juice from your Unders bet can be found by combining this selection on the Result & Total lines. Choose the odds which match your prediction.
Before placing your wager, discover the best bonus deals. Our guide highlights the most rewarding betting offers available.
Player Prop Picks
You can place a bet on Kevin Jennings (SMU) at -114 to have less than 287.5 passing yards. If you agree with our verdict that the line is too high, this QB Passing Yards wager is worth backing.
The odds for Kendrick Raphael (Louisville) to finish with fewer than 50.5 rushing yards stand at -114. If you agree with our verdict that the line is too high, this Player Rushing Yards wager is worth backing.
Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.
Same Game Parlay Picks
Get in the game with a same game parlay. Our picks are Under 59.5 on the total, Louisville to cover the -1.5 spread and Kevin Jennings (SMU) to go Under 287.5 passing yards.
We recommend a same game parlay as it’s a great way of betting on a single event. Many football bettors like to create a personalised wager which reflects their predictions for how a game is going to play out.
Correct Score Prediction
24
-
28
Louisville
There might not be too much between these teams, with our correct score pick being a 28-24 victory for the Cards. There are huge odds available when it comes to this prediction.
SMU vs Louisville Odds
The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.
The betting odds about Louisville winning is -127, with SMU priced up at +105 to achieve victory. From a percentage point-of-view, the leading sportsbooks give the visitors a 49% chance of success.
There is a spread of 1.5 and total points has a line of 59.5. The beauty of the Totals is that you only have to choose from one of two options. If you fancy Under 59.5, then the odds are -115.
The top sportsbooks cover every college football matchup with a great mix of game lines and team props. Whether you prefer to bet before kickoff or during the action, make sure to explore all available options.
Receiving Yards
Rushing Yards
Passing Yards
Louisville Keep Delivering at Home
Louisville have strung together three in a row at L&N Federal Credit Union Stadium. They have seven wins and three losses in the last 10 games at home, averaging 35.60 points on offense and surrendering 18.60 on defense.
SMU are 6-4 in their last 10 road games, averaging 27.70 points scored and 22.90 points allowed.
SMU beat Louisville 34-27 when the teams last met at L&N Federal Credit Union Stadium.
| Last 10 Games | W-L | P | PF | PA | O59.5 | U59.5 | |
|---|---|---|---|---|---|---|---|
 Louisville Home Stats |
7-3 | 54.20 | 35.60 | 18.60 | 3 | 7 | |
 SMU Away Stats |
6-4 | 50.60 | 27.70 | 22.90 | 1 | 9 | |
- W-L = Wins-Losses
- P = Avg. Points
- PF = Avg. Points For
- PA = Avg. Points Against
- O59.5 = Games Over 59.5 Points
- U59.5 = Games Under 59.5 Points
Latest regular season and playoff games stats.
SMU Stats
Louisville Cardinals Stats
- 8 wins and 2 defeats in the last 10 games
- 6 wins and 4 defeats in the last 10 games on the road
- +1.5 Betting Line: Have covered the spread in 9 of the last 10 games
- +1.5 Betting Line on the Road: Have covered the spread in 7 of the last 10 games on the road
- -1.5 Betting Line: Have covered the spread in 6 of the last 10 games
- -1.5 Betting Line at Home: Have covered the spread in 7 of the last 10 home games
- Game Totals: An average of 50.90 pts in the previous 10 games
- Game Totals on the Road: An average of 50.60 pts in the previous 10 games on the road
- Over 59.5: Covered in 2 of the previous 10 games
- Over 59.5 on the Road: Covered in 1 of the previous 10 games on the road
- Team Totals: Have scored an average of 33.20 pts and allowed 17.70 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 27.70 pts and allowed 22.90 pts in the last 10 games on the road
- Game Totals: An average of 53.00 pts in the previous 10 games
- Game Totals at Home: An average of 54.20 pts in the previous 10 home games
- Over 59.5: Covered in 3 of the previous 10 games
- Over 59.5 at Home: Covered in 3 of the previous 10 home games
- Team Totals: Have scored an average of 30.60 pts and allowed 22.40 pts in the last 10 games
- Team Totals at Home: Have scored an average of 35.60 pts and allowed 18.60 pts in the last 10 home games
| Atlantic Coast | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
Miami
|
2 | 0 | 122 | 13 | 109 | 1-0 | 1-0 | 2W |
Pittsburgh
|
3 | 0 | 98 | 34 | 64 | 3-0 | 0-0 | 3W |
|
SMU
|
2 | 0 | 83 | 34 | 49 | 1-0 | 1-0 | 2W |
Virginia
|
2 | 0 | 93 | 11 | 82 | 2-0 | 0-0 | 2W |
California
|
1 | 1 | 45 | 63 | -18 | 0-1 | 1-0 | 1W |
Duke
|
2 | 0 | 48 | 30 | 18 | 1-0 | 1-0 | 2W |
|
Louisville
|
1 | 1 | 97 | 54 | 43 | 1-0 | 0-1 | 1W |
Clemson
|
1 | 1 | 32 | 58 | -26 | 1-0 | 0-1 | 1W |
Boston College
|
1 | 1 | 43 | 55 | -12 | 1-0 | 0-1 | 1W |
Wake Forest
|
2 | 0 | 76 | 52 | 24 | 1-0 | 1-0 | 2W |
Virginia Tech
|
2 | 0 | 117 | 24 | 93 | 2-0 | 0-0 | 2W |
North Carolina
|
2 | 0 | 50 | 13 | 37 | 1-0 | 1-0 | 2W |
Georgia Tech
|
0 | 2 | 37 | 59 | -22 | 0-2 | 0-0 | 2L |
Florida State
|
1 | 1 | 58 | 44 | 14 | 1-1 | 0-0 | 1L |
NC State
|
1 | 1 | 81 | 34 | 47 | 1-0 | 0-1 | 1W |
Stanford
|
1 | 1 | 43 | 72 | -29 | 1-1 | 0-0 | 1L |
Syracuse
|
1 | 2 | 97 | 51 | 46 | 1-1 | 0-1 | 2L |
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