49ers vs Cowboys Prediction, Picks & Odds | 15 Nov 2026

49ers vs Cowboys Predictions

Best Bet

Under 55.5 Points @ -105

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Go for Under at -105. It might be defenses on top when the Cowboys clash with the Niners, with the 55.5 points line looking on the high side when it comes to the totals.

We highlight the top Niners vs Cowboys picks with our Best Bet, Player Props, Same Game Parlay and Correct Score Prediction. Dive into the sections below for a closer look at the card.

49ers vs Cowboys Preview

The San Francisco 49ers square off against the Dallas Cowboys at AT&T Stadium, with kickoff scheduled for 16:25 on Sunday, November 15.

San Francisco 49ers previous game saw them claim a 38-17 home win over Las Vegas Raiders at Levi's Stadium. The 49ers recorded 414 yards, breaking down to 224 passing and 190 rushing yards. The offense moved the chains 27 times and managed 5 touchdowns, with 2 through the air and 2 on the ground.

Dallas Cowboys have suffered three home defeats on the bounce. Their last victory was a 27-23 road success at Lucas Oil Stadium against Indianapolis Colts. The Cowboys recorded 508 yards, split between 329 passing and 179 rushing yards. The offense moved the chains 22 times and produced 3 touchdowns in total, with 2 through the air and one rushing TD.

H2H: 4 Wins in Previous 5 H2H Games for Niners

The Niners had the edge in the most recent matchup between these teams. At Levi's Stadium, they recorded a 30-24 win over the Cowboys. The Niners have won four of the past 5 games that these teams have played.

Quarterbacks

Brock Purdy

256.5 Passing Yards

Over -114

Under -114

Dak Prescott

269.5 Passing Yards

Over -114

Under -114

Best Bet

Under 55.5 points looks like an attractive selection on the totals. The teams might not be able to reach this combined amount and we can profit with this NFL pick at -105.

Key stats supporting our main match prediction:

• The 55.5 line hasn’t been covered in 8 of the last 10 49ers games.
• The 55.5 line hasn’t been covered in 4 of the last 5 49ers games.
• The 55.5 line hasn’t been covered in the last 3 49ers games.
• The 55.5 line hasn’t been covered in 3 of the last 5 Cowboys games.
• The 55.5 line hasn’t been covered in 11 of the last 20 Cowboys games at home.
• The 55.5 line hasn’t been covered in the last 4 games between these teams.

The NFL handicappers at Sportsgambler.com regularly track injury updates and pair that with current form. We also tap into a deep stats database to highlight the key numbers that help shape our predictions.

Under 55.5 Probability

If you go by the best betting sites, our pick has a 51.3% chance of winning. However, our analysts have this number closer to 60% based on their in-depth research. This is why we can recommend this wager.

Bigger odds are always a good thing and bettors can regularly move the line when it comes to betting Under on the Totals. Choose the option which suits you best.

Discover valuable betting promo codes, welcome offers, and free bets in our updated bonus guide before you play.

Under 55.5 Points @ -105 Watch Live Bet Now

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Player Prop Picks

Top Pick: George Kittle Anytime TD +115

You can place a bet on George Kittle (Niners) to record a TD at +115. All things considered, we believe the odds are appealing for betting on him in the Anytime Touchdown Scorer market.

Latest George Kittle Player Prop Odds

Touchdown

Anytime

+115

First

+1000

Receiving Yards

Over 61.5

-114

Under 61.5

-114

---

Javonte Williams Under 61.5 Rushing Yards -114

You can back Javonte Williams (Niners) at -114 to finish with fewer than 61.5 rushing yards. We’re confident he’ll fall short of the Player Rushing Yards line, as the total looks too high.

Latest Javonte Williams Player Prop Odds

Touchdown

Anytime

-169

First

+500

Receiving Yards

Over 13.5

-114

Under 13.5

-114

Rushing Yards

Over 61.5

-114

Under 61.5

-114

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

49ers 27 - 24 Cowboys

There might not be too much between these teams, with our correct score prediction being a 27-24 win for the Niners. There are enormous odds available when it comes to this pick.

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49ers vs Cowboys Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

San Francisco 49ers are -213 favorites and that means a 68% chance of winning this game according to the Moneyline betting odds with the sportsbooks. Dallas Cowboys are trading at bigger odds than their opponents and they can be backed at +180.

The spread is calculated to be 4.5, while total points comes in at 55.5. A Total wager relates to the number of points that will be scored overall. If you want to bet Under 55.5, there are odds of -105.

You can find a wide range of game lines and team props for every matchup, with the best NFL sportsbooks creating lots of different options. Explore the pre-game and in-game selections before placing your bets.

Moneyline

49ers

-213

Cowboys

+180

Point Spread

49ers -4.5

-100

Cowboys +4.5

-120

Total Points

Under 55.5

-105

Over 55.5

-115

Christian McCaffrey can be backed to score a touchdown at anytime at -270. He is the favorite to score the first TD at odds of +410.

Touchdown

Christian McCaffrey (49ers)

First TD

+410

Anytime TD

-270

Javonte Williams (Cowboys)

First TD

+500

Anytime TD

-169

CeeDee Lamb (Cowboys)

First TD

+850

Anytime TD

-115

George Kittle (49ers)

First TD

+1000

Anytime TD

+115

George Pickens (Cowboys)

First TD

+1200

Anytime TD

+170

Deebo Samuel (49ers)

First TD

+1300

Anytime TD

+185

Ryan Flournoy (Cowboys)

First TD

+1800

Anytime TD

+220

Kaelon Black (49ers)

First TD

+1800

Anytime TD

+290

Demarcus Robinson (49ers)

First TD

+2000

Anytime TD

+290

Brock Purdy (49ers)

First TD

+2000

Anytime TD

+270

Keenan Allen (49ers)

First TD

+2500

Anytime TD

+350

Brevyn Spann-Ford (Cowboys)

First TD

+2500

Anytime TD

+350

Jordan Watkins (49ers)

First TD

+2700

Anytime TD

+420

Dak Prescott (Cowboys)

First TD

+3500

Anytime TD

+650

Kyle Juszczyk (49ers)

First TD

+4000

Anytime TD

+650

Jonathan Mingo (Cowboys)

First TD

+4500

Anytime TD

+700

KaVontae Turpin (Cowboys)

First TD

+4500

Anytime TD

+700

Jacob Cowing (49ers)

First TD

+4500

Anytime TD

+900

Hunter Luepke (Cowboys)

First TD

+4500

Anytime TD

+650

Brandin Cooks (49ers)

First TD

+4500

Anytime TD

+900

Luke Farrell (49ers)

First TD

+5000

Anytime TD

+1000

Luke Schoonmaker (Cowboys)

First TD

+5500

Anytime TD

+800

Camden Brown (Cowboys)

First TD

+8000

Anytime TD

+1500

James Jordan (49ers)

First TD

+10000

Anytime TD

+1400

Brayden Willis (49ers)

First TD

+10000

Anytime TD

+2500

Receiving Yards

CeeDee Lamb (Cowboys)

Over 90.5

-114

Under 90.5

-114

George Kittle (49ers)

Over 61.5

-114

Under 61.5

-114

George Pickens (Cowboys)

Over 61.5

-114

Under 61.5

-114

Ryan Flournoy (Cowboys)

Over 37.5

-114

Under 37.5

-114

Deebo Samuel (49ers)

Over 35.5

-114

Under 35.5

-114

Christian McCaffrey (49ers)

Over 32.5

-114

Under 32.5

-114

Demarcus Robinson (49ers)

Over 28.5

-114

Under 28.5

-114

Jordan Watkins (49ers)

Over 25.5

-114

Under 25.5

-114

Brevyn Spann-Ford (Cowboys)

Over 20.5

-114

Under 20.5

-114

Keenan Allen (49ers)

Over 18.5

-114

Under 18.5

-114

Javonte Williams (Cowboys)

Over 13.5

-114

Under 13.5

-114

Kyle Juszczyk (49ers)

Over 7.5

-106

Under 7.5

-122

Rushing Yards

Christian McCaffrey (49ers)

Over 62.5

-114

Under 62.5

-114

Javonte Williams (Cowboys)

Over 61.5

-114

Under 61.5

-114

Kaelon Black (49ers)

Over 34.5

-114

Under 34.5

-114

Brock Purdy (49ers)

Over 18.5

-114

Under 18.5

-114

Dak Prescott (Cowboys)

Over 9.5

-114

Under 9.5

-114

Deebo Samuel (49ers)

Over 6.5

-114

Under 6.5

-114

Passing Yards

Dak Prescott (Cowboys)

Over 269.5

-114

Under 269.5

-114

Brock Purdy (49ers)

Over 256.5

-114

Under 256.5

-114

Cowboys Record Shows Five Losses From Last Ten Home Games

The Cowboys have four wins, five losses and one tie in the last 10 home games, putting up 28.20 points on average and giving up 28.30.

The Niners have seven wins and three losses in the last 10 games on the road, averaging 27.20 points on offense and surrendering 23.20 on defense.

The Niners beat the Cowboys 23-17 when they last met at AT&T Stadium.

Last 10 Games		W-L	P	PF	PA	O55.5	U55.5
Cowboys Home Stats		4-5	56.50	28.20	28.30	6	4
49ers Away Stats		7-3	50.40	27.20	23.20	4	6

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O55.5 = Games Over 55.5 Points
• U55.5 = Games Under 55.5 Points

Latest regular season and playoff games stats.

San Francisco 49ers Stats

Dallas Cowboys Stats

Moneyline

• 8 wins and 2 defeats in the last 10 games
• 7 wins and 3 defeats in the last 10 games on the road

Moneyline

• 4 wins and 6 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 home games

Point Spread

• -4.5 Betting Line: Have covered the spread in 6 of the last 10 games
• -4.5 Betting Line on the Road: Have covered the spread in 5 of the last 10 games on the road

Point Spread

• +4.5 Betting Line: Have covered the spread in 6 of the last 10 games
• +4.5 Betting Line at Home: Have covered the spread in 6 of the last 10 home games

Total Points

• Game Totals: An average of 48.00 pts in the previous 10 games
• Game Totals on the Road: An average of 50.40 pts in the previous 10 games on the road
• Over 55.5: Covered in 2 of the previous 10 games
• Over 55.5 on the Road: Covered in 4 of the previous 10 games on the road
• Team Totals: Have scored an average of 26.40 pts and allowed 21.60 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 27.20 pts and allowed 23.20 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 53.30 pts in the previous 10 games
• Game Totals at Home: An average of 55.00 pts in the previous 10 home games
• Over 55.5: Covered in 5 of the previous 10 games
• Over 55.5 at Home: Covered in 6 of the previous 10 home games
• Team Totals: Have scored an average of 26.30 pts and allowed 27.00 pts in the last 10 games
• Team Totals at Home: Have scored an average of 27.30 pts and allowed 27.70 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 361.10 Yds. Allowed 292.30 Yds
• Rushing Yards: Gained 126.50 Yds. Allowed 96.20 Yds
• Passing Yards: Gained 234.60 Yds. Allowed 196.10 Yds
• Total Touchdowns: Scored 3.40 TD. Allowed 2.20 TD
• Rushing Touchdowns: Scored 0.60 TD. Allowed 0.50 TD
• Passing Touchdowns: Scored 0.70 TD. Allowed 0.80 TD
• Total 1st Downs: Picked up 21.10. Allowed 17.70
• Total Turnovers: Committed 1.60. Committed by opponents 1.20
• Total Penalties: Committed 5.40. Committed by opponents 5.90
• Penalty Yards: Lost 49.60 Yds. Gained 45.60 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 353.00 Yds. Allowed 373.40 Yds
• Rushing Yards: Gained 107.50 Yds. Allowed 148.80 Yds
• Passing Yards: Gained 245.50 Yds. Allowed 224.60 Yds
• Total Touchdowns: Scored 3.00 TD. Allowed 3.00 TD
• Rushing Touchdowns: Scored 0.70 TD. Allowed 0.60 TD
• Passing Touchdowns: Scored 0.60 TD. Allowed 0.80 TD
• Total 1st Downs: Picked up 22.40. Allowed 22.30
• Total Turnovers: Committed 1.10. Committed by opponents 0.90
• Total Penalties: Committed 8.30. Committed by opponents 9.20
• Penalty Yards: Lost 76.10 Yds. Gained 76.00 Yds

Last 10 Games on the Road

• Total Yards: Gained 321.50 Yds. Allowed 324.80 Yds
• Rushing Yards: Gained 110.60 Yds. Allowed 111.40 Yds
• Passing Yards: Gained 210.90 Yds. Allowed 213.40 Yds
• Total Touchdowns: Scored 3.30 TD. Allowed 2.50 TD
• Rushing Touchdowns: Scored 0.80 TD. Allowed 0.70 TD
• Passing Touchdowns: Scored 1.70 TD. Allowed 1.40 TD
• Total 1st Downs: Picked up 20.50. Allowed 18.80
• Total Turnovers: Committed 1.60. Committed by opponents 1.40
• Total Penalties: Committed 3.70. Committed by opponents 6.30
• Penalty Yards: Lost 32.30 Yds. Gained 45.90 Yds

Last 10 Home Games

• Total Yards: Gained 380.90 Yds. Allowed 381.40 Yds
• Rushing Yards: Gained 112.30 Yds. Allowed 148.30 Yds
• Passing Yards: Gained 268.60 Yds. Allowed 233.10 Yds
• Total Touchdowns: Scored 2.90 TD. Allowed 3.40 TD
• Rushing Touchdowns: Scored 0.70 TD. Allowed 1.00 TD
• Passing Touchdowns: Scored 1.10 TD. Allowed 1.40 TD
• Total 1st Downs: Picked up 22.00. Allowed 21.90
• Total Turnovers: Committed 1.10. Committed by opponents 0.80
• Total Penalties: Committed 6.90. Committed by opponents 8.10
• Penalty Yards: Lost 57.30 Yds. Gained 67.90 Yds

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