Mississippi State vs LSU Prediction, Picks & Odds | 17 Oct 2026

Mississippi State vs LSU Predictions

Best Bet

Over 56.5 Points @ -115

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LSU and Mississippi State are capable of exceeding the set points total line which leads us to predict Over 56.5 as a value wager at -115.

We highlight the top Mississippi State vs LSU picks with our Best Bet, Player Props, Same Game Parlay and Correct Score Prediction. Scroll down for a detailed breakdown of each play.

Mississippi State vs LSU Preview

Mississippi State face LSU at Tiger Stadium, with kickoff scheduled for 12:00 on Saturday, October 17.

Mississippi State Bulldogs have enjoyed back-to-back road victories. Their previous game was a 56-23 home defeat against Alabama Crimson Tide at Davis Wade Stadium.

LSU Tigers have won four home games on the spin. On the road at Kroger Field in their last game, they were beaten 35-34 (OT) by Kentucky Wildcats.

H2H: LSU Have Won 4 Out of 5 on the H2H

The last matchup between LSU and Mississippi State saw the former win. It was a 41-14 scoreline at Davis Wade Stadium. In the past 5 games between the teams, LSU have won four.

Best Bet

There are odds of -115 about Over 56.5 points and this looks generous for this college football showdown. The bar might have been set too low in terms of total.

Key stats supporting our main match prediction:

• The 56.5 line has been covered in 8 of the last 10 Mississippi State games.
• The 56.5 line has been covered in 3 of the last 5 Mississippi State games this season.
• The 56.5 line has been covered in 3 of the last 4 LSU games at home this season.
• The 56.5 line has been covered in 4 of the last 6 LSU games this season.
• The 56.5 line has been covered in the last 2 LSU games.

Team news and current form always play a key role in shaping our expert CFB predictions. We also dig into the latest stats and trends to help deliver the most accurate picks possible.

Over 56.5 Probability

The best betting apps imply that our pick has a 53.5% chance of winning. However, our analysts in-depth research has found that the actual probability is closer to 60%. It's therefore regarded as a value wager.

If you have a strong hunch for Overs but want to get bigger odds, consider the Result & Total lines. Get both predictions correct for a profitable return.

Before placing your wager, explore the best betting offers. Our in-depth bonus guide features a wide range of promotions to choose from.

Over 56.5 Points @ -115 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Oct 15, 18:25). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Sam Leavitt Over 245.5 Passing Yards -114

The odds for Sam Leavitt (LSU) to go accumulate over 245.5 passing yards stand at -114. There’s an opportunity to place a QB Passing Yards bet, with him capable of covering an appealing line.

Latest Sam Leavitt Player Prop Odds

Passing Yards

Over 245.5

-114

Under 245.5

-114

Rushing Yards

Over 31.5

-114

Under 31.5

-114

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

MS State 21 - 45 LSU

Rather than backing LSU to triumph, there’s the alternative to try your luck when it comes to the correct score lines. Take a chance on a 45-21 win in their favor.

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Mississippi State vs LSU Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

With an estimated 88% chance of winning, the sportsbooks are taking no chances with their -714 betting odds about LSU triumphing in this college game. If you’re looking for an alternative angle, Mississippi State are trading at +490.

15.5 is the spread and 56.5 is the total points line. The Totals offers football bettors an alternative way of getting involved. If you fancy Over 56.5, this outcome can be backed at -115. 

You can find a wide range of team props and game lines for every college football matchup, with the best sportsbooks creating lots of different options. Explore the pre-game and in-game selections before placing your wagers.

Moneyline

MS State

+490

LSU

-714

Point Spread

MS State +15.5

-110

LSU -15.5

-110

Total Points

Under 56.5

-105

Over 56.5

-115

Receiving Yards

Anthony Evans III (MS State)

Over 72.5

-114

Under 72.5

-114

Winston Watkins Jr. (LSU)

Over 59.5

-114

Under 59.5

-114

Jackson Harris (LSU)

Over 49.5

-114

Under 49.5

-114

Zion Ragins (MS State)

Over 31.5

-114

Under 31.5

-114

Sanfrisco Magee (MS State)

Over 30.5

-114

Under 30.5

-114

Eugene Wilson III (LSU)

Over 29.5

-114

Under 29.5

-114

Jayce Brown (LSU)

Over 17.5

-118

Under 17.5

-112

Sam West (MS State)

Over 13.5

-114

Under 13.5

-114

Rushing Yards

Dilin Jones (LSU)

Over 87.5

-114

Under 87.5

-114

Sam Leavitt (LSU)

Over 31.5

-114

Under 31.5

-114

Can LSU Keep Rolling at Home?

LSU have rattled off six consecutive victories at Tiger Stadium. They own a 9-1 mark in their past 10 home games, averaging 35.10 points on offense and surrendering 15.50 on defense.

Mississippi State have four wins and six losses in the last 10 road games, averaging 26.70 points on offense and surrendering 30.20 on defense.

LSU beat Mississippi State 31-16 in their most recent meeting at Tiger Stadium.

Last 10 Games		W-L	P	PF	PA	O56.5	U56.5
LSU Home Stats		9-1	50.60	35.10	15.50	5	5
Mississippi State Away Stats		4-6	56.90	26.70	30.20	4	6

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O56.5 = Games Over 56.5 Points
• U56.5 = Games Under 56.5 Points

Latest regular season and playoff games stats.

Mississippi State Bulldogs Stats

LSU Tigers Stats

Moneyline

• 5 wins and 5 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 games on the road

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 9 wins and 1 defeat in the last 10 home games

Point Spread

• +14.5 Betting Line: Have covered the spread in 6 of the last 10 games
• +14.5 Betting Line on the Road: Have covered the spread in 7 of the last 10 games on the road

Point Spread

• -14.5 Betting Line: Have covered the spread in 4 of the last 10 games
• -14.5 Betting Line at Home: Have covered the spread in 5 of the last 10 home games

Total Points

• Game Totals: An average of 67.50 pts in the previous 10 games
• Game Totals on the Road: An average of 56.90 pts in the previous 10 games on the road
• Over 56.5: Covered in 8 of the previous 10 games
• Over 56.5 on the Road: Covered in 4 of the previous 10 games on the road
• Team Totals: Have scored an average of 32.90 pts and allowed 34.60 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 26.70 pts and allowed 30.20 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 53.40 pts in the previous 10 games
• Game Totals at Home: An average of 50.60 pts in the previous 10 home games
• Over 56.5: Covered in 5 of the previous 10 games
• Over 56.5 at Home: Covered in 5 of the previous 10 home games
• Team Totals: Have scored an average of 33.60 pts and allowed 19.80 pts in the last 10 games
• Team Totals at Home: Have scored an average of 35.10 pts and allowed 15.50 pts in the last 10 home games

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