Ohio State vs Indiana Prediction, Picks & Odds | 17 Oct 2026
Ohio State vs Indiana Predictions
With Indiana capable of remaining close to Ohio State, backing them on the spread could be the way forward. Odds of -114 is available that the +3.5 is covered.
Get our expert Ohio State vs Indiana predictions, including our Best Bet, Player Props, Same Game Parlay and Correct Score Pick. Browse the dedicated sections below for a comprehensive look at the wagers.
Ohio State vs Indiana Preview
Ohio State go up against Indiana at Memorial Stadium, with kickoff scheduled for 12:00 on Saturday, October 17.
Ohio State Buckeyes made it four consecutive wins after a 45-16 home success over Maryland Terrapins at Ohio Stadium.
Indiana Hoosiers got a sixth straight win in their last game. It was a 20-17 road triumph at Memorial Stadium when meeting Nebraska Cornhuskers.
H2H: 6 Ohio State Victories in Last 7 H2H Matchups
Indiana won the most recent matchup between these teams. A 13-10 victory was registered against Ohio State at Lucas Oil Stadium. The previous 7 games featuring these teams have resulted in six Ohio State victories.
Quarterbacks
Julian Sayin
Josh Hoover
Best Bet
We’re confident that Indiana can push for a victory in this college football showdown and the +3.5 about them on the spread makes lots of appeal. Take -114 that they cover the line.
Key stats supporting our main match prediction:
The CFB handicappers at Sportsgambler.com stay on top of injuries and team form that could impact the outcome. We also leave no stone unturned when analyzing the latest stats to support every prediction.
Indiana +3.5 Probability
According to the top sportsbooks, there’s a 53.2% likelihood of our pick landing a return. However, our research has found that the actual probability is closer to 60%. This college bet can therefore be backed with confidence.
If you’re looking for an option to wagering Indiana on the spread, then consider the Winning Margin lines. You can choose from a wide range of fixed intervals and prices.
Smart bettors check the promos first. Browse our updated guide for the best welcome bonuses available today.
Player Prop Picks
You can back Josh Hoover (Indiana) at -114 to exceed 216.5 passing yards. With confidence, we can back him to cover the generous QB Passing Yards line, as all the signs point to him reaching the expected total.
The odds for Nick Marsh (Indiana) to surpass 74.5 receiving yards stand at -114. The line for him on the Overs looks attractive and bettors can get plenty of juice from this Player Receiving Yards wager.
Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.
Same Game Parlay Pick
Try out our same game parlay pick which starts with Indiana +3.5. We’ve also gone for Under 50.5 points and Josh Hoover (Indiana) to go Over 216.5 passing yards.
A football same game parlay is a single event wager where you make predictions that are going to happen in a particular game. Should a bettor get these picks correct, then they can achieve a big return from a small stake.
Correct Score Prediction
20
-
23
Indiana
A close battle could be on the cards. We’ll bet on the Hoosiers to claim a 23-20 victory at huge odds and this correct score pick should hopefully be a fun one.
Ohio State vs Indiana Odds
The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.
Ohio State are regarded as having a 63% chance of winning this college game according to the latest betting odds. The sportsbooks have priced them up at -169. For those wanting to oppose the market leader, you can get +140 about Indiana.
The spread is 3.5 and the total points line is currently 50.5. A Total wager is always available and can often provide value selections. If you want to bet Under 50.5, there are odds of -115.
If you’re getting ready to place a college football bet, head over to one of the top betting apps and explore the wide variety of game lines and team props. Take your time to spot the most appealing opportunities.
Receiving Yards
Rushing Yards
Passing Yards
Will Indiana Extend Their Home Winning Streak?
Indiana are 10-0 in their last 10 home games, scoring 49.10 points per contest and conceding 8.40.
Ohio State have nine wins and one loss in the last 10 games away from home, posting 31.00 points per contest while yielding 13.70.
The last Memorial Stadium meeting saw Ohio State beat Indiana 23-3. The last 3 head-to-head matchups at Memorial Stadium have all gone the way of Ohio State.
| Last 10 Games | W-L | P | PF | PA | O50.5 | U50.5 | |
|---|---|---|---|---|---|---|---|
 Indiana Home Stats |
10-0 | 57.50 | 49.10 | 8.40 | 8 | 2 | |
 Ohio State Away Stats |
9-1 | 44.70 | 31.00 | 13.70 | 2 | 8 | |
- W-L = Wins-Losses
- P = Avg. Points
- PF = Avg. Points For
- PA = Avg. Points Against
- O50.5 = Games Over 50.5 Points
- U50.5 = Games Under 50.5 Points
Latest regular season and playoff games stats.
Ohio State Buckeyes Stats
Indiana Hoosiers Stats
- 7 wins and 3 defeats in the last 10 games
- 9 wins and 1 defeat in the last 10 games on the road
- 10 wins and 0 defeats in the last 10 games
- 10 wins and 0 defeats in the last 10 home games
- -3.5 Betting Line: Have covered the spread in 7 of the last 10 games
- -3.5 Betting Line on the Road: Have covered the spread in 9 of the last 10 games on the road
- +3.5 Betting Line: Have covered the spread in the last 10 games
- +3.5 Betting Line at Home: Have covered the spread in the last 10 home games
- Game Totals: An average of 48.30 pts in the previous 10 games
- Game Totals on the Road: An average of 44.70 pts in the previous 10 games on the road
- Over 50.5: Covered in 5 of the previous 10 games
- Over 50.5 on the Road: Covered in 2 of the previous 10 games on the road
- Team Totals: Have scored an average of 34.90 pts and allowed 13.40 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 31.00 pts and allowed 13.70 pts in the last 10 games on the road
- Game Totals: An average of 50.20 pts in the previous 10 games
- Game Totals at Home: An average of 53.10 pts in the previous 10 home games
- Over 50.5: Covered in 5 of the previous 10 games
- Over 50.5 at Home: Covered in 6 of the previous 10 home games
- Team Totals: Have scored an average of 37.50 pts and allowed 12.70 pts in the last 10 games
- Team Totals at Home: Have scored an average of 42.00 pts and allowed 11.10 pts in the last 10 home games
| Big Ten | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
|
Indiana
|
6 | 0 | 241 | 71 | 170 | 4-0 | 2-0 | 6W |
|
Ohio State
|
5 | 1 | 256 | 79 | 177 | 4-0 | 1-1 | 4W |
UCLA
|
5 | 0 | 196 | 90 | 106 | 2-0 | 3-0 | 5W |
Wisconsin
|
4 | 1 | 158 | 83 | 75 | 3-0 | 1-1 | 4W |
USC
|
6 | 1 | 255 | 176 | 79 | 4-1 | 2-0 | 2W |
Iowa
|
5 | 1 | 186 | 87 | 99 | 3-1 | 2-0 | 1W |
Nebraska
|
5 | 1 | 235 | 91 | 144 | 4-1 | 1-0 | 1L |
Minnesota
|
4 | 2 | 173 | 131 | 42 | 3-1 | 1-1 | 1L |
Purdue
|
3 | 3 | 193 | 188 | 5 | 2-2 | 1-1 | 2W |
Northwestern
|
4 | 1 | 177 | 81 | 96 | 4-0 | 0-1 | 2W |
Oregon
|
3 | 2 | 205 | 110 | 95 | 2-1 | 1-1 | 1L |
Illinois
|
3 | 3 | 191 | 167 | 24 | 2-2 | 1-1 | 1W |
Maryland
|
2 | 4 | 168 | 196 | -28 | 1-2 | 1-2 | 4L |
Michigan State
|
2 | 4 | 128 | 154 | -26 | 2-2 | 0-2 | 4L |
Michigan
|
3 | 2 | 115 | 79 | 36 | 3-1 | 0-1 | 2L |
Washington
|
3 | 3 | 157 | 133 | 24 | 3-2 | 0-1 | 3L |
Penn State
|
3 | 3 | 183 | 111 | 72 | 2-2 | 1-1 | 3L |
Rutgers
|
1 | 4 | 150 | 161 | -11 | 1-3 | 0-1 | 1L |
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