Louisville vs Syracuse Prediction, Picks & Odds | 17 Oct 2026

Louisville vs Syracuse Predictions

Best Bet

Syracuse +14.5 @ -110

Bet Now T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

We’ve smashed into Syracuse +14.5 and this spread bet at -110 means we need the underdogs to avoid a big defeat against Louisville.

Discover our expert Louisville vs Syracuse betting picks, featuring our Best Bet, Player Props, Same Game Parlay and Correct Score Prediction. Read on for the full analysis behind each play.

Louisville vs Syracuse Preview

Louisville battle Syracuse at JMA Wireless Dome, with kickoff scheduled for 19:30 on Saturday, October 17.

Louisville Cardinals have lost their previous two on the road. Their most recent game was at home at L&N Federal Credit Union Stadium where they recorded a 44-20 victory over Florida State Seminoles.

Syracuse Orange were defeated in their last game. On the road, they suffered a 28-25 reverse against Virginia Cavaliers at Scott Stadium.

H2H: 31-7 Syracuse Victory in Previous H2H Meeting

Syracuse beat Louisville when the teams last met. It was a 31-7 scoreline at JMA Wireless Dome. In the past 4 H2H meetings, Louisville have won three.

Best Bet

Syracuse can avoid a heavy defeat in this college football showdown, with bettors able to back the underdogs against the spread. They should be able to cover +14.5 which have been made available at -110.

Key stats supporting our main match prediction:

• The +14.5 line has been covered by Syracuse in 5 consecutive games.
• The +14.5 line has been covered by Syracuse in 14 of their last 20 games at home.
• The +14.5 line has been covered by Syracuse in 6 of their last 10 games at home.
• The -14.5 line hasn’t been covered by Louisville in 7 consecutive games on the road.
• The -14.5 line hasn’t been covered by Louisville in 19 of their last 20 games on the road.
• The -14.5 line hasn’t been covered by Louisville in 9 of their last 10 games on the road.

Incoming team news often impacts the betting lines and odds in significant ways. Our college football handicappers factor this in alongside recent form, while key stats are also carefully weighed to strengthen each pick.

Syracuse +14.5 Probability

According to the top sportsbooks, there’s a 52.4% likelihood of our pick landing a return. After careful examination, our team of cappers calculate this probability to be closer to 60%. It's why we think it’s worth placing this college wager.

If you want a viable alternative to backing Syracuse on the spread, then the Winning Margin lines could be up your street. Choose from a wide range of options.

Before placing a wager, see what betting offers are on the table. Our in-depth guide lists the top welcome bonuses right now.

Syracuse +14.5 @ -110 Bet Now

BetMGM Promo Up To $1500 in Bonus Bets Get Bonus T&C apply. Gamble responsibly 18+

Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Oct 16, 02:25). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Lincoln Kienholz Under 220.5 Passing Yards -114

You can place a bet on Lincoln Kienholz (Louisville) at -114 to finish with fewer than 220.5 passing yards. We're confident he’ll fall short of the QB Passing Yards line, so we're backing the Under.

Latest Lincoln Kienholz Player Prop Odds

Passing Yards

Over 220.5

-114

Under 220.5

-114

Rushing Yards

Over 24.5

-114

Under 24.5

-114

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Louisville 34 - 28 Syracuse

There is a speculative bet that can be enjoyed on the Cards when it comes to the correct score lines. Taking them to win 34-28 should provide some entertainment.

T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Louisville vs Syracuse Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

The sportsbooks are taking no chances with their Moneyline odds of -714 about Louisville which reflects they have a 88% chance of winning this college game. For those wanting to back Syracuse, you will find +480 about the underdogs.

14.5 is where the spread lies, with total points being 55.5 right now. Having a bet on the Totals is one of the most popular football wagers. Those that want to back Under 55.5 can find odds of -108 available.

You’ll find a great variety of team props and game lines for most college football showdowns. The best betting apps provide a strong mix of pre-game and in-game options to suit your betting style.

Moneyline

Louisville

-714

Syracuse

+480

Point Spread

Louisville -14.5

-110

Syracuse +14.5

-110

Total Points

Under 55.5

-108

Over 55.5

-112

Rushing Yards

Lincoln Kienholz (Louisville)

Over 24.5

-114

Under 24.5

-114

Syracuse Sitting on Five Wins in Past Ten at Home

Syracuse are 5-5 in their last 10 home games, posting 28.80 points per contest while yielding 25.90.

Louisville have been beaten three straight times on the road. They are 6-4 in their last 10 road games, averaging 30.20 points on offense and surrendering 28.10 on defense.

The last time the teams met at JMA Wireless Dome, Syracuse defeated Louisville 31-7.

Last 10 Games		W-L	P	PF	PA	O55.5	U55.5
Syracuse Home Stats		5-5	54.70	28.80	25.90	3	7
Louisville Away Stats		6-4	58.30	30.20	28.10	5	5

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O55.5 = Games Over 55.5 Points
• U55.5 = Games Under 55.5 Points

Latest regular season and playoff games stats.

Louisville Cardinals Stats

Syracuse Orange Stats

Moneyline

• 5 wins and 5 defeats in the last 10 games
• 6 wins and 4 defeats in the last 10 games on the road

Moneyline

• 2 wins and 8 defeats in the last 10 games
• 5 wins and 5 defeats in the last 10 home games

Point Spread

• -14.5 Betting Line: Have covered the spread in 3 of the last 10 games
• -14.5 Betting Line on the Road: Have covered the spread in 1 of the last 10 games on the road

Point Spread

• +14.5 Betting Line: Have covered the spread in 5 of the last 10 games
• +14.5 Betting Line at Home: Have covered the spread in 6 of the last 10 home games

Total Points

• Game Totals: An average of 57.60 pts in the previous 10 games
• Game Totals on the Road: An average of 58.30 pts in the previous 10 games on the road
• Over 55.5: Covered in 6 of the previous 10 games
• Over 55.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 33.00 pts and allowed 24.60 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 30.20 pts and allowed 28.10 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 54.90 pts in the previous 10 games
• Game Totals at Home: An average of 54.70 pts in the previous 10 home games
• Over 55.5: Covered in 4 of the previous 10 games
• Over 55.5 at Home: Covered in 3 of the previous 10 home games
• Team Totals: Have scored an average of 21.90 pts and allowed 33.00 pts in the last 10 games
• Team Totals at Home: Have scored an average of 28.80 pts and allowed 25.90 pts in the last 10 home games

Where to Bet on American Football Games

Top American Football Pages