Oregon vs USC Prediction, Picks & Odds | 26 Sep 2026

College Football Betting Preview: Oregon vs USC

Oregon square off against USC at LA Memorial Coliseum, with kickoff scheduled for 19:30 on Saturday, September 26.

There’s some value on the spread and we like USC at +2.5. We’re very happy to take them with this advantage against Oregon at -100.

Oregon Ducks claimed a victory in their previous game. A 84-0 home win occurred against Portland State Vikings at Autzen Stadium.

USC Trojans got a fourth straight win in their last game. It was a 42-35 road triumph at SHI Stadium when meeting Rutgers Scarlet Knights.

Head-to-Head Statistics

Oregon won the last matchup between the pair. Enjoying a 42-27 triumph when facing USC at Autzen Stadium. In the past 4 H2H games, Oregon have won every time.

Quarterbacks

Dante Moore

271.5 Passing Yards

Over -114

Under -114

Jayden Maiava

263.5 Passing Yards

Over -114

Under -114

Oregon vs USC Prediction & Picks

Get the full betting picture for Oregon vs USC, including a key match prediction, our best correct score selection, top player prop picks and a ready-made bet builder.

Game Prediction

USC look easy to back at -100 considering they’ve been given a spread of +2.5. This looks a good number when squaring off in this college football battle.

The CFB handicappers at Sportsgambler.com start by analyzing recent form and staying on top of injury news before making any picks. From there, we interpret the story the stats are telling to help shape our predictions.

Key Oregon vs USC stats:

• The +2.5 line has been covered by USC in 11 consecutive games at home.
• The +2.5 line has been covered by USC in 16 of their last 20 games.
• The -2.5 line hasn’t been covered by Oregon in 3 of their last 5 games on the road.
• The -2.5 line hasn’t been covered by Oregon in 2 consecutive games on the road.

USC +2.5 Probability

If you go by the best sportsbooks, our pick has a 50% prospect of winning. Based on our in-depth research, our analysts calculate the actual probability to be 55-60%. It's therefore regarded as a value wager.

As a wagering alternative, you can choose to buy or sell points when it comes to your spread pick. Buy if you want a safer bet and sell to get more juice from the line.

Before placing a wager, see what betting offers are on the table. Our in-depth guide lists the top welcome bonuses right now.

Our Game Prediction

USC +2.5 @ -100 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Sep 25, 02:25). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Dante Moore Under 271.5 Passing Yards -114

The odds for Dante Moore (Oregon) to end with fewer than 271.5 passing yards are -114. We're confident he’ll fall short of the QB Passing Yards line, so we're backing the Under.

Latest Dante Moore Player Prop Odds

Passing Yards

Over 271.5

-114

Under 271.5

-114

Rushing Yards

Over 4.5

-114

Under 4.5

-114

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Jamari Johnson Under 41.5 Receiving Yards -114

Jamari Johnson (USC) is priced at -114 to finish with fewer than 41.5 receiving yards. It’s reasonable to expect he may fall short, making the Player Receiving Yards line appealing.

Latest Jamari Johnson Player Prop Odds

Receiving Yards

Over 41.5

-114

Under 41.5

-114

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Oregon 27 - 31 USC

Don’t pass up the opportunity to have a speculative bet on the Trojans to land a 31-27 win. We don’t think that there will be too much between the teams.

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Oregon vs USC Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

With the sportsbooks giving them a 60% probability of winning this college game, Oregon might be a popular parlay pick. That is reflected in their -149 Moneyline betting odds. USC are regarded as a long shot to win and you can currently back them at +125.

2.5 is the spread and 61.5 is the total points line. Football bettors regularly enjoy the opportunity to wager on the Totals. If you’re going for Under 61.5, this outcome can be backed at -110.

Whether you are wagering pre-game or in-game on college football, the top betting apps let you feast on a wide range of team props and game lines. The selections are practically endless, and it’s awesome to have so many options at your fingertips.

Moneyline

Oregon

-149

USC

+125

Point Spread

Oregon -2.5

-122

USC +2.5

-100

Total Points

Under 61.5

-110

Over 61.5

-110

Receiving Yards

Evan Stewart (Oregon)

Over 68.5

-114

Under 68.5

-114

Dakorien Moore (Oregon)

Over 55.5

-112

Under 55.5

-118

Tanook Hines (USC)

Over 54.5

-114

Under 54.5

-114

Jamari Johnson (Oregon)

Over 41.5

-114

Under 41.5

-114

Mark Bowman (USC)

Over 37.5

-114

Under 37.5

-114

Corey Simms (USC)

Over 31.5

-114

Under 31.5

-114

Messiah Hampton (Oregon)

Over 30.5

-114

Under 30.5

-114

Dierre Hill Jr. (Oregon)

Over 14.5

-114

Under 14.5

-114

Rushing Yards

King Miller (USC)

Over 72.5

-114

Under 72.5

-114

Jordon Davison (Oregon)

Over 66.5

-118

Under 66.5

-112

Dierre Hill Jr. (Oregon)

Over 56.5

-114

Under 56.5

-114

Waymond Jordan (USC)

Over 35.5

-114

Under 35.5

-114

Dante Moore (Oregon)

Over 4.5

-114

Under 4.5

-114

Jayden Maiava (USC)

Over 2.5

-114

Under 2.5

-114

Passing Yards

Dante Moore (Oregon)

Over 271.5

-114

Under 271.5

-114

Jayden Maiava (USC)

Over 263.5

-114

Under 263.5

-114

USC Looking to Extend Strong Home Form

USC have ten wins and zero loss in the last 10 games at home, averaging 43.10 points scored and 18.10 points allowed.

Oregon have gone 8-2 across their last 10 games games on the road, scoring 29.40 points per contest and conceding 20.30.

When the teams last met at LA Memorial Coliseum, Oregon beat USC 31-24.

Last 10 Games		W-L	P	PF	PA	O61.5	U61.5
USC Home Stats		10-0	61.20	43.10	18.10	5	5
Oregon Away Stats		8-2	49.70	29.40	20.30	3	7

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O61.5 = Games Over 61.5 Points
• U61.5 = Games Under 61.5 Points

Latest regular season and playoff games stats.

Oregon Ducks Stats

USC Stats

Moneyline

• 8 wins and 2 defeats in the last 10 games
• 8 wins and 2 defeats in the last 10 games on the road

Moneyline

• 8 wins and 2 defeats in the last 10 games
• 10 wins and 0 defeats in the last 10 home games

Point Spread

• -2.5 Betting Line: Have covered the spread in 7 of the last 10 games
• -2.5 Betting Line on the Road: Have covered the spread in 7 of the last 10 games on the road

Point Spread

• +2.5 Betting Line: Have covered the spread in 8 of the last 10 games
• +2.5 Betting Line at Home: Have covered the spread in the last 10 home games

Total Points

• Game Totals: An average of 59.90 pts in the previous 10 games
• Game Totals on the Road: An average of 49.70 pts in the previous 10 games on the road
• Over 61.5: Covered in 5 of the previous 10 games
• Over 61.5 on the Road: Covered in 3 of the previous 10 games on the road
• Team Totals: Have scored an average of 37.30 pts and allowed 22.60 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 29.40 pts and allowed 20.30 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 56.80 pts in the previous 10 games
• Game Totals at Home: An average of 61.20 pts in the previous 10 home games
• Over 61.5: Covered in 4 of the previous 10 games
• Over 61.5 at Home: Covered in 5 of the previous 10 home games
• Team Totals: Have scored an average of 34.00 pts and allowed 22.80 pts in the last 10 games
• Team Totals at Home: Have scored an average of 43.10 pts and allowed 18.10 pts in the last 10 home games

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