Cardinals vs 49ers Prediction, Picks & Odds | 27 Sep 2026

NFL Betting Preview: Cardinals vs Niners

The Arizona Cardinals battle the San Francisco 49ers at Levi's Stadium, with kickoff scheduled for 16:05 on Sunday, September 27.

The total line looks to be on the low side at 47.5. There’s a strong chance that the Niners and the Cardinals will conspire to go above the line and we’re backing Over at -118.

Arizona Cardinals were beaten 31-7 at State Farm Stadium in their previous game, being turned over at home to Seattle Seahawks. The Cardinals totaled 151 yards, split between 81 passing and 70 rushing yards. The offense scored one touchdown and picked up 10 first downs.

San Francisco 49ers have enjoyed back-to-back wins, most recently beating Miami Dolphins 35-13. It was a home success at Levi's Stadium. The 49ers totaled 382 yards, split between 287 passing and 95 rushing yards. They generated 23 first downs to go with 5 trips to the end zone.

Head-to-Head Statistics

The Niners have beaten the Cardinals in the last two meetings. They won 16-15 at Levi's Stadium and triumphed 41-22 at State Farm Stadium. The previous 10 H2H meetings have involved the Niners winning six times.

Quarterbacks

Jacoby Brissett

225.5 Passing Yards

Over -114

Under -114

Brock Purdy

235.5 Passing Yards

Over -114

Under -114

Cardinals vs 49ers Prediction & Picks

Take on Cardinals vs 49ers with our in-depth betting analysis, featuring an expert match prediction, scoreline advice, key player props and a value-driven bet builder.

Game Prediction

There are odds of -118 available for our NFL pick. We think that the points will be racked up cumulatively and we’re going for Over 47.5 in total.

We closely track recent form and look for patterns that may impact the outcome. The same goes for injuries to key players. When combined with the most relevant stats, this gives us a strong foundation for accurate NFL predictions.

Key Cardinals vs 49ers stats:

• The 47.5 line has been covered in 6 of the last 10 Cardinals games.
• The 47.5 line has been covered in 3 of the last 5 Cardinals games on the road.
• The 47.5 line has been covered in 3 of the last 5 49ers games at home.

Over 47.5 Probability

The top NFL sportsbooks make it a 54.1% chance that our pick is settled as a winner. However, our research has found that the actual probability is closer to 60%. This wager can therefore be backed with confidence.

It’s possible to increase the odds on your Over wager by combining it with other picks. A Bet Builder allows you to place multiple bets from the same game into one single parlay.

Tap into great value before you bet. Our guide rounds up today’s best free bets, promo codes and sign-up promotions.

Our Game Prediction

Over 47.5 Points @ -118 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Sep 25, 22:25). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Tyler Allgeier Anytime TD +175

The odds for Tyler Allgeier (Cardinals) to make it to the end zone are +175. He looks like an attractive wager to take it to the house and we recommend backing this Anytime Touchdown Scorer selection.

Latest Tyler Allgeier Player Prop Odds

Touchdown

Anytime

+175

First

+1000

Receiving Yards

Over 7.5

-114

Under 7.5

-114

Rushing Yards

Over 33.5

-114

Under 33.5

-114

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Kaelon Black Over 32.5 Rushing Yards -114

You can place a bet on Kaelon Black (Cardinals) at -114 to rack up over 32.5 rushing yards. We're confident in him covering the Player Rushing Yards line and hitting our Over bet.

Latest Kaelon Black Player Prop Odds

Touchdown

Anytime

+290

First

+1600

Rushing Yards

Over 32.5

-114

Under 32.5

-114

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Cardinals 23 - 34 49ers

There are many different ways to back the 49ers on the correct score betting and something like 34-23 in their favor might be along the right lines at huge odds.

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Cardinals vs 49ers Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

San Francisco 49ers are massive -455 favorites. They are regarded as 82% likely to win this game judging by the sportsbooks’ latest Moneyline odds. For those wanting to back Arizona Cardinals, you will find +350 about the underdogs.

There is a spread of 8.5 and total points has a line of 47.5. The Totals offers NFL fans an alternative way of getting involved. The Over 47.5 selection is available to back at -118.

You can find hundreds of team props and game lines for every National Football League matchup, with the top sportsbooks creating lots of different options. Check out the pre-game and in-game selections before placing your bets.

Moneyline

Cardinals

+350

49ers

-455

Point Spread

Cardinals +8.5

-110

49ers -8.5

-110

Total Points

Under 47.5

-104

Over 47.5

-118

Christian McCaffrey can be backed to score a TD at any stage at -270. There is the opportunity to back the market leader to grab the first touchdown at +300.

Touchdown

Christian McCaffrey (49ers)

First TD

+300

Anytime TD

-270

Mike Evans (49ers)

First TD

+900

Anytime TD

+145

Tyler Allgeier (Cardinals)

First TD

+1000

Anytime TD

+175

George Kittle (49ers)

First TD

+1000

Anytime TD

+170

Jeremiyah Love (Cardinals)

First TD

+1100

Anytime TD

+160

Deebo Samuel (49ers)

First TD

+1100

Anytime TD

+165

Brock Purdy (49ers)

First TD

+1400

Anytime TD

+250

Trey McBride (Cardinals)

First TD

+1500

Anytime TD

+195

Kaelon Black (49ers)

First TD

+1600

Anytime TD

+290

Michael Wilson (Cardinals)

First TD

+2000

Anytime TD

+290

Marvin Harrison Jr. (Cardinals)

First TD

+2200

Anytime TD

+350

KhaDarel Hodge (49ers)

First TD

+2700

Anytime TD

+600

Jacob Cowing (49ers)

First TD

+2700

Anytime TD

+600

Kyle Juszczyk (49ers)

First TD

+3000

Anytime TD

+600

Jacoby Brissett (Cardinals)

First TD

+3300

Anytime TD

+650

Luke Farrell (49ers)

First TD

+3500

Anytime TD

+900

Kendrick Bourne (Cardinals)

First TD

+4000

Anytime TD

+750

Hunter Long (Cardinals)

First TD

+7000

Anytime TD

+1200

Brayden Willis (49ers)

First TD

+7500

Anytime TD

+1900

Jordan Watkins (49ers)

First TD

+8000

Anytime TD

+2000

Elijah Higgins (Cardinals)

First TD

+10000

Anytime TD

+2000

Bam Knight (Cardinals)

First TD

+10000

Anytime TD

+2700

James Jordan (49ers)

First TD

+10000

Anytime TD

+2000

Devin Duvernay (Cardinals)

First TD

+10000

Anytime TD

+2700

Simi Fehoko (Cardinals)

First TD

+10000

Anytime TD

+2700

Jalen Brooks (Cardinals)

First TD

+10000

Anytime TD

+6000

Receiving Yards

Trey McBride (Cardinals)

Over 67.5

-114

Under 67.5

-114

Mike Evans (49ers)

Over 55.5

-114

Under 55.5

-114

George Kittle (49ers)

Over 44.5

-114

Under 44.5

-114

Michael Wilson (Cardinals)

Over 44.5

-114

Under 44.5

-114

Deebo Samuel (49ers)

Over 40.5

-114

Under 40.5

-114

Christian McCaffrey (49ers)

Over 38.5

-114

Under 38.5

-114

Marvin Harrison Jr. (Cardinals)

Over 33.5

-114

Under 33.5

-114

Kendrick Bourne (Cardinals)

Over 23.5

-114

Under 23.5

-114

Jeremiyah Love (Cardinals)

Over 14.5

-114

Under 14.5

-114

Tyler Allgeier (Cardinals)

Over 7.5

-114

Under 7.5

-114

Rushing Yards

Christian McCaffrey (49ers)

Over 55.5

-114

Under 55.5

-114

Jeremiyah Love (Cardinals)

Over 37.5

-114

Under 37.5

-114

Tyler Allgeier (Cardinals)

Over 33.5

-114

Under 33.5

-114

Kaelon Black (49ers)

Over 32.5

-114

Under 32.5

-114

Brock Purdy (49ers)

Over 16.5

-114

Under 16.5

-114

Jacoby Brissett (Cardinals)

Over 7.5

-114

Under 7.5

-114

Passing Yards

Brock Purdy (49ers)

Over 235.5

-114

Under 235.5

-114

Jacoby Brissett (Cardinals)

Over 225.5

-114

Under 225.5

-114

Niners Have Picked Up Six Wins From Last Ten Home Games

The Niners have gone 6-4 across their last 10 home games, posting 25.40 points per contest while yielding 23.00.

The Cardinals have three wins and seven losses in the last 10 games away from home, putting up 20.80 points on average and giving up 26.90.

The last time these teams met at Levi's Stadium, the Niners came out on top 16-15 against the Cardinals. Looking at the last 7 head-to-head matchups at Levi's Stadium, the Niners have four victories and the Cardinals three.

Last 10 Games		W-L	P	PF	PA	O47.5	U47.5
49ers Home Stats		6-4	48.40	25.40	23.00	5	5
Cardinals Away Stats		3-7	47.70	20.80	26.90	5	5

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O47.5 = Games Over 47.5 Points
• U47.5 = Games Under 47.5 Points

Latest regular season and playoff games stats.

Arizona Cardinals Stats

San Francisco 49ers Stats

Moneyline

• 1 win and 9 defeats in the last 10 games
• 3 wins and 7 defeats in the last 10 games on the road

Moneyline

• 8 wins and 2 defeats in the last 10 games
• 6 wins and 4 defeats in the last 10 home games

Point Spread

• +8.5 Betting Line: Have covered the spread in 4 of the last 10 games
• +8.5 Betting Line on the Road: Have covered the spread in 6 of the last 10 games on the road

Point Spread

• -8.5 Betting Line: Have covered the spread in 6 of the last 10 games
• -8.5 Betting Line at Home: Have covered the spread in 4 of the last 10 home games

Total Points

• Game Totals: An average of 50.40 pts in the previous 10 games
• Game Totals on the Road: An average of 47.70 pts in the previous 10 games on the road
• Over 47.5: Covered in 6 of the previous 10 games
• Over 47.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 18.60 pts and allowed 31.80 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 20.80 pts and allowed 26.90 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 46.60 pts in the previous 10 games
• Game Totals at Home: An average of 48.40 pts in the previous 10 home games
• Over 47.5: Covered in 4 of the previous 10 games
• Over 47.5 at Home: Covered in 5 of the previous 10 home games
• Team Totals: Have scored an average of 26.70 pts and allowed 19.90 pts in the last 10 games
• Team Totals at Home: Have scored an average of 25.40 pts and allowed 23.00 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 323.50 Yds. Allowed 367.50 Yds
• Rushing Yards: Gained 74.80 Yds. Allowed 137.40 Yds
• Passing Yards: Gained 248.70 Yds. Allowed 230.10 Yds
• Total Touchdowns: Scored 2.10 TD. Allowed 3.80 TD
• Rushing Touchdowns: Scored 0.20 TD. Allowed 1.10 TD
• Passing Touchdowns: Scored 1.50 TD. Allowed 2.10 TD
• Total 1st Downs: Picked up 18.80. Allowed 22.60
• Total Turnovers: Committed 1.20. Committed by opponents 0.90
• Total Penalties: Committed 6.80. Committed by opponents 4.60
• Penalty Yards: Lost 56.10 Yds. Gained 35.30 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 348.30 Yds. Allowed 306.40 Yds
• Rushing Yards: Gained 122.00 Yds. Allowed 123.00 Yds
• Passing Yards: Gained 226.30 Yds. Allowed 183.40 Yds
• Total Touchdowns: Scored 3.20 TD. Allowed 2.30 TD
• Rushing Touchdowns: Scored 0.70 TD. Allowed 0.90 TD
• Passing Touchdowns: Scored 1.60 TD. Allowed 1.00 TD
• Total 1st Downs: Picked up 21.90. Allowed 17.90
• Total Turnovers: Committed 1.30. Committed by opponents 0.80
• Total Penalties: Committed 3.40. Committed by opponents 5.30
• Penalty Yards: Lost 31.90 Yds. Gained 36.70 Yds

Last 10 Games on the Road

• Total Yards: Gained 324.70 Yds. Allowed 350.00 Yds
• Rushing Yards: Gained 99.20 Yds. Allowed 123.30 Yds
• Passing Yards: Gained 225.50 Yds. Allowed 226.70 Yds
• Total Touchdowns: Scored 2.30 TD. Allowed 3.00 TD
• Rushing Touchdowns: Scored 0.30 TD. Allowed 1.00 TD
• Passing Touchdowns: Scored 1.80 TD. Allowed 1.50 TD
• Total 1st Downs: Picked up 20.00. Allowed 21.60
• Total Turnovers: Committed 0.90. Committed by opponents 1.00
• Total Penalties: Committed 5.40. Committed by opponents 5.80
• Penalty Yards: Lost 47.00 Yds. Gained 47.50 Yds

Last 10 Home Games

• Total Yards: Gained 375.70 Yds. Allowed 333.80 Yds
• Rushing Yards: Gained 111.20 Yds. Allowed 119.40 Yds
• Passing Yards: Gained 264.50 Yds. Allowed 214.40 Yds
• Total Touchdowns: Scored 3.10 TD. Allowed 2.70 TD
• Rushing Touchdowns: Scored 1.00 TD. Allowed 0.90 TD
• Passing Touchdowns: Scored 1.60 TD. Allowed 1.50 TD
• Total 1st Downs: Picked up 23.20. Allowed 19.90
• Total Turnovers: Committed 1.60. Committed by opponents 0.30
• Total Penalties: Committed 4.80. Committed by opponents 6.00
• Penalty Yards: Lost 42.30 Yds. Gained 42.10 Yds

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