Patriots vs Saints Prediction, Picks & Odds | 12 Oct 2025

NFL Betting Preview: Patriots vs Saints

The New England Patriots go up against the New Orleans Saints in this NFL Week 6 matchup at Caesars Superdome, with kickoff scheduled for 13:00 on Sunday, October 12. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

We’re confident of backing the Patriots to cover the -3.5 spread when they clash with the Saints. This is a more than generous line and they look a value pick at -105.

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New England Patriots won their previous game 23-20. This road victory at Highmark Stadium against Buffalo Bills was their second on the spin. The Patriots totaled 338 yards, split between 267 passing and 71 rushing yards. The offense produced 21 first downs and found the end zone twice.

New Orleans Saints were winners last time out. It was a 26-14 home victory against New York Giants at Caesars Superdome. The Saints put up 332 total yards, made up of 244 through the air and 88 on the ground. They picked up 18 first downs to go along with two touchdowns.

Head-to-Head Statistics

The Saints beat the Patriots in their last head-to-head matchup. It was a 34-0 scoreline at Gillette Stadium.

Quarterbacks

Drake Maye

235.5 Passing Yards

Over -112

Under -112

Spencer Rattler

211.5 Passing Yards

Over -112

Under -112

Patriots vs Saints Prediction & Picks

Our Patriots vs Saints betting preview covers everything you need, including a key match prediction, correct score insight, top player prop bets and a value-packed bet builder recommendation.

Game Prediction

Get with the betting favorites with a -3.5 spread. We’re backing the Patriots at odds of -105 to enjoy a solid victory in this NFL matchup.

The NFL handicappers at Sportsgambler.com stay on top of injuries and team form that could impact the outcome. We also leave no stone unturned when analyzing the latest stats to support every prediction.

Key Patriots vs Saints stats:

• The +3.5 line hasn’t been covered by Saints in 4 of their last 5 games this season.
• The +3.5 line hasn’t been covered by Saints in 7 of their last 10 games.

Patriots -3.5 Probability

When you look at the latest betting odds, our pick has a 51.3% chance of winning. In our opinion, there’s actually a probability of success closer to 60%. It is therefore regarded as a value bet.

There’s the opportunity to sell points and that means moving the line until you’re happy with the wager. It means a riskier spread bet but a bigger return on the odds available.

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Our Game Prediction

Patriots -3.5 @ -105 Bet Now

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Player Prop Picks

Top Pick: TreVeyon Henderson Anytime TD +125

TreVeyon Henderson (Patriots) can be backed at +125 to record a TD. There are appealing odds on offer for this Anytime Touchdown Scorer pick, and we believe it's an attractive wager for him to punch it in.

Latest TreVeyon Henderson Player Prop Odds

Touchdown

Anytime

+135

First

+800

Receiving Yards

Over 16.5

-112

Under 16.5

-112

Rushing Yards

Over 35.5

-112

Under 35.5

-112

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Drake Maye Over 22.5 Rushing Yards -118

The odds for Drake Maye (Saints) to go over 22.5 rushing yards are -118. With confidence, we can back him to cover the generous Player Rushing Yards line, as all the signs point to him reaching the expected total.

Latest Drake Maye Player Prop Odds

Touchdown

Anytime

+240

First

+1200

Passing Yards

Over 235.5

-112

Under 235.5

-112

Rushing Yards

Over 23.5

-112

Under 23.5

-112

Correct Score Prediction

Patriots 24 - 13 Saints

The Patriots can be wagered in lots of different ways and this includes the correct score lines. There’s the chance to back them to win 24-13 for a big potential return.

Patriots vs Saints Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

For this game, the sportsbooks’ Moneyline betting odds mean New England Patriots are -167 favorites to win and that means a 63% chance of landing a victory. New Orleans Saints are trading at bigger odds than their opponents and they can be backed at +140.

3 is the spread and 43.5 is the total points line. The Totals offers NFL fans an alternative way of getting involved. If you’re going for Under 43.5, this outcome can be backed at -110.

Take a well-rounded approach when placing your bets. The top NFL betting sites are packed with team props and game lines, so focus on finding the selection that reflects your read on the matchup.

Moneyline

Patriots

-167

Saints

+140

Point Spread

Patriots -3

-110

Saints +3

-110

Total Points

Under 43.5

-110

Over 43.5

-110

There is +120 available that Rhamondre Stevenson scores a TD at any stage. He is available at +650 to record the first touchdown which makes him favorite.

Touchdown

Rhamondre Stevenson (Patriots)

First TD

+650

Anytime TD

+120

TreVeyon Henderson (Patriots)

First TD

+800

Anytime TD

+135

Alvin Kamara (Saints)

First TD

+900

Anytime TD

+160

Stefon Diggs (Patriots)

First TD

+950

Anytime TD

+175

Chris Olave (Saints)

First TD

+1100

Anytime TD

+210

Hunter Henry (Patriots)

First TD

+1100

Anytime TD

+195

Drake Maye (Patriots)

First TD

+1200

Anytime TD

+240

Taysom Hill (Saints)

First TD

+1300

Anytime TD

+250

Rashid Shaheed (Saints)

First TD

+1400

Anytime TD

+250

Kayshon Boutte (Patriots)

First TD

+1600

Anytime TD

+320

Juwan Johnson (Saints)

First TD

+1600

Anytime TD

+290

Kendre Miller (Saints)

First TD

+1800

Anytime TD

+360

Foster Moreau (Saints)

First TD

+3000

Anytime TD

+550

DeMario Douglas (Patriots)

First TD

+3000

Anytime TD

+650

Mack Hollins (Patriots)

First TD

+3000

Anytime TD

+650

Brandin Cooks (Saints)

First TD

+3500

Anytime TD

+700

Spencer Rattler (Saints)

First TD

+3500

Anytime TD

+750

Austin Hooper (Patriots)

First TD

+4000

Anytime TD

+750

Jack Stoll (Saints)

First TD

+8000

Anytime TD

+1700

Devaughn Vele (Saints)

First TD

+8000

Anytime TD

+1300

Terrell Jennings (Patriots)

First TD

+8000

Anytime TD

+1600

Kyle Williams (Patriots)

First TD

+10000

Anytime TD

+2200

Mason Tipton (Saints)

First TD

+10000

Anytime TD

+3300

Jack Westover (Patriots)

First TD

+10000

Anytime TD

+4000

Devin Neal (Saints)

First TD

+10000

Anytime TD

+1700

Receiving Yards

Stefon Diggs (Patriots)

Over 63.5

-112

Under 63.5

-112

Chris Olave (Saints)

Over 54.5

-112

Under 54.5

-112

Rashid Shaheed (Saints)

Over 44.5

-112

Under 44.5

-112

Hunter Henry (Patriots)

Over 42.5

-112

Under 42.5

-112

Juwan Johnson (Saints)

Over 38.5

-112

Under 38.5

-112

Kayshon Boutte (Patriots)

Over 29.5

-112

Under 29.5

-112

Alvin Kamara (Saints)

Over 18.5

-112

Under 18.5

-112

TreVeyon Henderson (Patriots)

Over 16.5

-112

Under 16.5

-112

Brandin Cooks (Saints)

Over 15.5

-112

Under 15.5

-112

Rhamondre Stevenson (Patriots)

Over 15.5

-112

Under 15.5

-112

Mack Hollins (Patriots)

Over 8.5

-112

Under 8.5

-112

Rushing Yards

Rhamondre Stevenson (Patriots)

Over 45.5

-112

Under 45.5

-112

Alvin Kamara (Saints)

Over 36.5

-112

Under 36.5

-112

TreVeyon Henderson (Patriots)

Over 35.5

-112

Under 35.5

-112

Kendre Miller (Saints)

Over 31.5

-112

Under 31.5

-112

Drake Maye (Patriots)

Over 23.5

-112

Under 23.5

-112

Spencer Rattler (Saints)

Over 18.5

-112

Under 18.5

-112

Taysom Hill (Saints)

Over 16.5

-112

Under 16.5

-112

Passing Yards

Drake Maye (Patriots)

Over 235.5

-112

Under 235.5

-112

Spencer Rattler (Saints)

Over 211.5

-112

Under 211.5

-112

Among the various options for wagering on the NFL, you will find that micro betting is provided. It focuses on short-term in-game outcomes such as whether a touchdown will be scored within the next 10 minutes.

Saints Have Seven Losses From Past Ten at Home

The Saints are 3-7 in their last 10 home games, putting up 19.50 points on average and giving up 24.10.

The Patriots are 3-7 in their last 10 road games, averaging 17.70 points scored and 24.40 points allowed.

Last 10 Games		W-L	P	PF	PA	O45.5	U45.5
Saints Home Stats		3-7	43.60	19.50	24.10	3	7
Patriots Away Stats		3-7	42.10	17.70	24.40	4	6

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O45.5 = Games Over 45.5 Points
• U45.5 = Games Under 45.5 Points

Latest regular season and playoff games stats.

New England Patriots Stats

New Orleans Saints Stats

Moneyline

• 4 wins and 6 defeats in the last 10 games
• 3 wins and 7 defeats in the last 10 games on the road

Moneyline

• 2 wins and 8 defeats in the last 10 games
• 3 wins and 7 defeats in the last 10 home games

Point Spread

• -3.5 Betting Line: Have covered the spread in 3 of the last 10 games
• -3.5 Betting Line on the Road: Have covered the spread in 2 of the last 10 games on the road

Point Spread

• +3.5 Betting Line: Have covered the spread in 3 of the last 10 games
• +3.5 Betting Line at Home: Have covered the spread in 4 of the last 10 home games

Total Points

• Game Totals: An average of 45.30 pts in the previous 10 games
• Game Totals on the Road: An average of 42.10 pts in the previous 10 games on the road
• Over 45.5: Covered in 5 of the previous 10 games
• Over 45.5 on the Road: Covered in 4 of the previous 10 games on the road
• Team Totals: Have scored an average of 21.70 pts and allowed 23.60 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 17.70 pts and allowed 24.40 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 40.60 pts in the previous 10 games
• Game Totals at Home: An average of 43.60 pts in the previous 10 home games
• Over 45.5: Covered in 4 of the previous 10 games
• Over 45.5 at Home: Covered in 3 of the previous 10 home games
• Team Totals: Have scored an average of 15.40 pts and allowed 25.20 pts in the last 10 games
• Team Totals at Home: Have scored an average of 19.50 pts and allowed 24.10 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 328.50 Yds. Allowed 329.80 Yds
• Rushing Yards: Gained 109.10 Yds. Allowed 118.40 Yds
• Passing Yards: Gained 219.40 Yds. Allowed 211.40 Yds
• Total Touchdowns: Scored 2.50 TD. Allowed 2.70 TD
• Rushing Touchdowns: Scored 1.00 TD. Allowed 0.80 TD
• Passing Touchdowns: Scored 1.30 TD. Allowed 1.60 TD
• Total 1st Downs: Picked up 19.70. Allowed 20.50
• Total Turnovers: Committed 1.40. Committed by opponents 0.90
• Total Penalties: Committed 7.30. Committed by opponents 7.40
• Penalty Yards: Lost 63.20 Yds. Gained 54.10 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 282.40 Yds. Allowed 346.90 Yds
• Rushing Yards: Gained 95.80 Yds. Allowed 138.30 Yds
• Passing Yards: Gained 186.60 Yds. Allowed 208.60 Yds
• Total Touchdowns: Scored 1.50 TD. Allowed 2.80 TD
• Rushing Touchdowns: Scored 0.30 TD. Allowed 0.90 TD
• Passing Touchdowns: Scored 1.10 TD. Allowed 1.80 TD
• Total 1st Downs: Picked up 18.40. Allowed 21.20
• Total Turnovers: Committed 0.90. Committed by opponents 1.00
• Total Penalties: Committed 7.70. Committed by opponents 8.30
• Penalty Yards: Lost 57.30 Yds. Gained 68.00 Yds

Last 10 Games on the Road

• Total Yards: Gained 290.30 Yds. Allowed 355.00 Yds
• Rushing Yards: Gained 96.40 Yds. Allowed 127.10 Yds
• Passing Yards: Gained 193.90 Yds. Allowed 227.90 Yds
• Total Touchdowns: Scored 1.90 TD. Allowed 2.70 TD
• Rushing Touchdowns: Scored 0.60 TD. Allowed 0.70 TD
• Passing Touchdowns: Scored 1.10 TD. Allowed 1.50 TD
• Total 1st Downs: Picked up 17.40. Allowed 20.80
• Total Turnovers: Committed 1.50. Committed by opponents 0.90
• Total Penalties: Committed 6.90. Committed by opponents 7.40
• Penalty Yards: Lost 54.50 Yds. Gained 55.00 Yds

Last 10 Home Games

• Total Yards: Gained 320.10 Yds. Allowed 389.00 Yds
• Rushing Yards: Gained 109.80 Yds. Allowed 155.70 Yds
• Passing Yards: Gained 210.30 Yds. Allowed 232.80 Yds
• Total Touchdowns: Scored 2.10 TD. Allowed 2.80 TD
• Rushing Touchdowns: Scored 0.50 TD. Allowed 0.80 TD
• Passing Touchdowns: Scored 1.40 TD. Allowed 1.90 TD
• Total 1st Downs: Picked up 17.60. Allowed 23.20
• Total Turnovers: Committed 1.10. Committed by opponents 1.10
• Total Penalties: Committed 7.00. Committed by opponents 6.50
• Penalty Yards: Lost 55.80 Yds. Gained 51.50 Yds

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