Notre Dame vs Purdue Prediction, Picks & Odds | 26 Sep 2026
College Football Betting Preview: Notre Dame vs Purdue
Notre Dame go up against Purdue at Ross-Ade Stadium, with kickoff scheduled for 14:00 on Saturday, September 26.
If you agree with our prediction that Notre Dame can be superior to Purdue, you can get -118 for this pick against the spread. The favorites should be capable of covering the -27.5 betting line.
Notre Dame Fighting Irish beat Michigan State Spartans in their previous game, making it three straight victories. It was a 27-10 home win at Notre Dame Stadium.
Purdue Boilermakers have suffered defeat in their last two games. Most recently, a 52-38 scoreline occurred on the road at Rose Bowl against UCLA Bruins.
Head-to-Head Statistics
Notre Dame beat Purdue in their last head-to-head matchup. It was a 56-30 scoreline at Notre Dame Stadium. In the previous 3 H2H meetings, Notre Dame have won every time.
Quarterbacks
CJ Carr
Ryan Browne
Notre Dame vs Purdue Prediction & Picks
Get ahead of the game with our Notre Dame vs Purdue betting rundown, featuring our trusted match prediction, likely score outcome, standout player prop plays and a fully loaded bet builder.
Game Prediction
Notre Dame can finish well clear in this college football matchup and that means we’re going for the favorites against the spread. There is -118 on offer that they are able to cover the -27.5 betting line.
We only publish our CFB predictions once we’ve got a clear and confident read on team news and the latest form. We also stay sharp by digging into the most valuable stats to support every pick we make.
Key Notre Dame vs Purdue stats:
Notre Dame -27.5 Probability
If you go by the best sportsbooks, our pick has a 54.1% prospect of winning. However, our cappers think that the probability is close to 60% taking all factors into consideration. It's why we think it’s worth placing this college wager.
As a betting option, you can choose to buy or sell points when it comes to your selection. Buy if you want a safer wager and sell to get more juice from the line.
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Player Prop Picks
Ryan Browne (Purdue) is available at -114 to end with fewer than 217.5 passing yards. We're confident he’ll fall short of the QB Passing Yards line, so we're backing the Under.
Micah Gilbert (Purdue) is priced at -114 to record fewer than 54.5 receiving yards. The line looks too high and we’re confident he’ll fall short of the Player Receiving Yards total.
Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.
Same Game Parlay Picks
We’ve compiled a same game parlay that includes Notre Dame -27.5 on the spread, combined with Under 58.5 and Ryan Browne (Purdue) to go Under 217.5 passing yards.
The same game parlay option allows you to combine different outcomes within the same game. You need all your predictions to be correct although bettors love to place a tailored football bet on the event which interests them most.
Correct Score Prediction
41
-
10
Purdue
We’re going for the Irish to claim a 41-10 victory and the good news is that there are huge odds for this outcome. A small stake can return a potentially large amount.
Notre Dame vs Purdue Odds
The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.
You might not get rich backing Notre Dame at -5000. However, the sportsbooks’ betting odds imply a 98% chance of winning this college game. The market suggests that Purdue are least likely to win at +1600.
The current spread is 27.5 and the total points line is 58.5. Football fans love the chance to get an alternative angle by going for a Total wager. If you fancy Under 58.5, then the odds are -114.
The best betting apps provide tons of game lines and team props for nearly every college football matchup. Take a few moments to browse all the markets so you can place a bet that matches your insight.
Receiving Yards
Rushing Yards
Passing Yards
Purdue Home Record Reads Seven Losses in Previous Ten Matches
Purdue own a 3-7 mark in their past 10 home games, scoring 23.60 points per contest and conceding 31.60.
Notre Dame have rattled off four road wins in a row. They have gone 9-1 across their last 10 road games, putting up 37.20 points on average and giving up 18.10.
The last Ross-Ade Stadium meeting saw Notre Dame beat Purdue 66-7.
| Last 10 Games | W-L | P | PF | PA | O58.5 | U58.5 | |
|---|---|---|---|---|---|---|---|
 Purdue Home Stats |
3-7 | 55.20 | 23.60 | 31.60 | 5 | 5 | |
 Notre Dame Away Stats |
9-1 | 55.30 | 37.20 | 18.10 | 4 | 6 | |
- W-L = Wins-Losses
- P = Avg. Points
- PF = Avg. Points For
- PA = Avg. Points Against
- O58.5 = Games Over 58.5 Points
- U58.5 = Games Under 58.5 Points
Latest regular season and playoff games stats.
Notre Dame Fighting Irish Stats
Purdue Boilermakers Stats
- 10 wins and 0 defeats in the last 10 games
- 9 wins and 1 defeat in the last 10 games on the road
- -27.5 Betting Line: Have covered the spread in 6 of the last 10 games
- -27.5 Betting Line on the Road: Have covered the spread in 3 of the last 10 games on the road
- +27.5 Betting Line: Have covered the spread in 8 of the last 10 games
- +27.5 Betting Line at Home: Have covered the spread in 8 of the last 10 home games
- Game Totals: An average of 53.60 pts in the previous 10 games
- Game Totals on the Road: An average of 55.30 pts in the previous 10 games on the road
- Over 58.5: Covered in 3 of the previous 10 games
- Over 58.5 on the Road: Covered in 4 of the previous 10 games on the road
- Team Totals: Have scored an average of 42.00 pts and allowed 11.60 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 37.20 pts and allowed 18.10 pts in the last 10 games on the road
- Game Totals: An average of 54.60 pts in the previous 10 games
- Game Totals at Home: An average of 55.20 pts in the previous 10 home games
- Over 58.5: Covered in 5 of the previous 10 games
- Over 58.5 at Home: Covered in 5 of the previous 10 home games
- Team Totals: Have scored an average of 20.40 pts and allowed 34.20 pts in the last 10 games
- Team Totals at Home: Have scored an average of 23.60 pts and allowed 31.60 pts in the last 10 home games
| Big Ten | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
UCLA
|
3 | 0 | 125 | 72 | 53 | 2-0 | 1-0 | 3W |
USC
|
4 | 0 | 172 | 91 | 81 | 3-0 | 1-0 | 4W |
Indiana
|
3 | 0 | 145 | 16 | 129 | 3-0 | 0-0 | 3W |
Maryland
|
2 | 1 | 126 | 49 | 77 | 1-1 | 1-0 | 1L |
Wisconsin
|
2 | 1 | 103 | 60 | 43 | 2-0 | 0-1 | 2W |
Oregon
|
2 | 1 | 149 | 66 | 83 | 2-0 | 0-1 | 1W |
Ohio State
|
2 | 1 | 138 | 30 | 108 | 2-0 | 0-1 | 1W |
Minnesota
|
2 | 1 | 113 | 52 | 61 | 2-1 | 0-0 | 1W |
Michigan State
|
2 | 1 | 75 | 54 | 21 | 2-0 | 0-1 | 1L |
Illinois
|
2 | 1 | 117 | 64 | 53 | 2-1 | 0-0 | 1W |
Iowa
|
3 | 0 | 111 | 13 | 98 | 3-0 | 0-0 | 3W |
Washington
|
3 | 0 | 88 | 40 | 48 | 3-0 | 0-0 | 3W |
Penn State
|
3 | 0 | 127 | 22 | 105 | 2-0 | 1-0 | 3W |
Northwestern
|
2 | 0 | 75 | 25 | 50 | 2-0 | 0-0 | 2W |
Nebraska
|
3 | 0 | 139 | 35 | 104 | 3-0 | 0-0 | 3W |
Michigan
|
3 | 0 | 82 | 39 | 43 | 3-0 | 0-0 | 3W |
|
Purdue
|
1 | 2 | 118 | 109 | 9 | 1-1 | 0-1 | 2L |
Rutgers
|
0 | 3 | 77 | 107 | -30 | 0-2 | 0-1 | 3L |
| Independents I-A | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
|
Notre Dame
|
3 | 0 | 120 | 23 | 97 | 3-0 | 0-0 | 3W |
UConn
|
2 | 1 | 118 | 65 | 53 | 1-1 | 1-0 | 1W |
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