Cardinals vs Giants Prediction, Picks & Odds | 04 Oct 2026

Cardinals vs Giants Predictions

Best Bet

Giants +2.5 @ -110

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There’s some excellent value on the spread and we like the Giants +2.5. We’re very happy to take Big Blue with this advantage against the Cardinals at -110.

We highlight the top Cardinals vs Giants predictions with our Best Bet, Player Props, Same Game Parlay and Correct Score Pick. Full analysis of each play is detailed in the dedicated segments below.

Cardinals vs Giants Preview

The Arizona Cardinals face the New York Giants in a Week 4 matchup at MetLife Stadium, with kickoff scheduled for 13:00 on Sunday, October 4.

Arizona’s trip to the Meadowlands offers a matchup of veteran quarterbacks, with Jacoby Brissett and Jameis Winston entrusted with their respective offenses. There is some historical familiarity between these franchises from their long-ago days as division rivals, but compared with Week 4’s divisional showdowns, prime-time games and marquee quarterback matchups, this carries a more modest national profile.

The Arizona Cardinals are 1-2 after suffering their second straight loss, falling 36-30 to the San Francisco 49ers at Levi's Stadium. Arizona finished with 365 total yards, including 272 net passing and 93 rushing, while recording 27 first downs and scoring three touchdowns.

Jacoby Brissett completed 38-of-52 passes for 280 yards and two touchdowns without an interception, while also adding a rushing score. Michael Wilson led Arizona's receiving corps with 11 catches for 89 yards and a touchdown on 17 targets.

The New York Giants are 2-1 after earning their second win of the season with a 12-7 home victory over the Tennessee Titans at MetLife Stadium. New York finished with 238 total yards, including 100 net passing and 138 rushing, while recording 16 first downs.

Jameis Winston completed 14-of-22 passes for 118 yards without a touchdown or interception. Cam Skattebo led the Giants with 20 carries for 60 yards and added three catches for 40 yards to finish with 100 yards from scrimmage, while Najee Harris contributed 52 rushing yards on nine carries.

H2H: Cards Have Won 2 of the Last 3 Meetings

New York took the most recent matchup, rallying for a 31-28 road victory over Arizona at State Farm Stadium in September 2023. Despite that result, the Cards have won two of the last three meetings between the teams.

Quarterbacks

Jacoby Brissett

230.5 Passing Yards

Over -114

Under -114

Jameis Winston

208.5 Passing Yards

Over -114

Under -114

Best Bet

We wouldn’t be surprised to see the Giants win this NFL matchup. In terms of landing extra value, it makes sense to take +2.5 when it comes to the spread at -110.

Key stats supporting our main match prediction:

• The +2.5 line has been covered by Giants in 4 of their last 5 games.
• The +2.5 line has been covered by Giants in 3 consecutive games at home.
• The -2.5 line hasn’t been covered by Cardinals in 9 of their last 10 games.
• The -2.5 line hasn’t been covered by Cardinals in 16 of their last 20 games.
• The -2.5 line hasn’t been covered by Cardinals in 2 consecutive games.

Our expert NFL predictions always start with checking the latest team news and understanding how it might impact the matchup. From there, we dive into the most valuable stats to uncover the insights that matter most.

Giants +2.5 Probability

The best sportsbooks are estimating that there is a 52.4% likelihood of this pick winning. However, our cappers think that the probability sits between 55-60% taking all factors into consideration. That means we are regarding it as a value wager.

There’s an opportunity to secure bigger odds and this can be achieved by moving the line. Squeeze more juice from your pick by taking an alternative wagering view.

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Giants +2.5 @ -110 Bet Now

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Player Prop Picks

Top Pick: Jameis Winston Over 208.5 Passing Yards -114

The odds for Jameis Winston (Giants) to accumulate over 208.5 passing yards are -114. The line for him on the Overs looks attractive and bettors can get plenty of juice from this QB Passing Yards wager.

Latest Jameis Winston Player Prop Odds

Touchdown

Anytime

+800

First

+4000

Passing Yards

Over 208.5

-114

Under 208.5

-114

Rushing Yards

Over 5.5

-114

Under 5.5

-114

---

Najee Harris Over 23.5 Rushing Yards -114

Najee Harris (Giants) is available at -114 to record more than 23.5 rushing yards. We feel confident that he’ll cover the Player Rushing Yards line, which looks generous.

Latest Najee Harris Player Prop Odds

Touchdown

Anytime

+340

First

+1700

Rushing Yards

Over 23.5

-114

Under 23.5

-114

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Cardinals 24 - 27 Giants

Don’t pass up the opportunity to have a speculative wager on the Giants to claim a 27-24 victory. We don’t think that there will be too much between the teams.

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Cardinals vs Giants Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

There are betting odds of +118 that New York Giants land victory, with Arizona Cardinals alternatively at -139. This means the top sportsbooks give the road team a 58% chance of winning.

The spread is currently 2.5, with the total points line at 44.5. NFL fans regularly enjoy the opportunity to bet on the Totals. Those who wager Under 44.5 can get -115.

If you’re betting on the National Football League, we recommend visiting the top betting apps and scanning through the many team props and game lines. There’s the opportunity to wager pre-game and in-game.

Moneyline

Cardinals

-139

Giants

+118

Point Spread

Cardinals -2.5

-110

Giants +2.5

-110

Total Points

Under 44.5

-115

Over 44.5

-105

Favorite Jeremiyah Love is priced at +450 to be the first player to score a touchdown. There’s also the opportunity to back him to score a TD at anytime at odds of -135.

Touchdown

Jeremiyah Love (Cardinals)

First TD

+450

Anytime TD

-135

Cam Skattebo (Giants)

First TD

+460

Anytime TD

-141

Trey McBride (Cardinals)

First TD

+850

Anytime TD

+155

Malik Nabers (Giants)

First TD

+1100

Anytime TD

+200

Michael Wilson (Cardinals)

First TD

+1200

Anytime TD

+220

Tyler Allgeier (Cardinals)

First TD

+1500

Anytime TD

+290

Isaiah Likely (Giants)

First TD

+1600

Anytime TD

+280

Najee Harris (Giants)

First TD

+1700

Anytime TD

+340

Marvin Harrison Jr. (Cardinals)

First TD

+1800

Anytime TD

+350

Malachi Fields (Giants)

First TD

+2200

Anytime TD

+460

Kendrick Bourne (Cardinals)

First TD

+2500

Anytime TD

+600

Jacoby Brissett (Cardinals)

First TD

+2700

Anytime TD

+500

Darnell Mooney (Giants)

First TD

+3000

Anytime TD

+650

Theo Johnson (Giants)

First TD

+3500

Anytime TD

+800

Jameis Winston (Giants)

First TD

+4000

Anytime TD

+800

Elijah Higgins (Cardinals)

First TD

+4500

Anytime TD

+1200

Tyrone Tracy Jr. (Giants)

First TD

+4500

Anytime TD

+1000

Devin Singletary (Giants)

First TD

+4500

Anytime TD

+1000

Braxton Berrios (Giants)

First TD

+5500

Anytime TD

+1200

Hunter Long (Cardinals)

First TD

+5500

Anytime TD

+1400

Jalen Brooks (Cardinals)

First TD

+7000

Anytime TD

+2000

Devin Duvernay (Cardinals)

First TD

+7500

Anytime TD

+1800

Bam Knight (Cardinals)

First TD

+8000

Anytime TD

+1600

Charlie Jones (Giants)

First TD

+8000

Anytime TD

+1800

Chris Manhertz (Giants)

First TD

+10000

Anytime TD

+2700

Patrick Ricard (Giants)

First TD

+10000

Anytime TD

+2700

Thomas Fidone (Giants)

First TD

+10000

Anytime TD

+2700

Simi Fehoko (Cardinals)

First TD

+10000

Anytime TD

+3300

Reggie Virgil (Cardinals)

First TD

+10000

Anytime TD

+3300

Receiving Yards

Trey McBride (Cardinals)

Over 63.5

-114

Under 63.5

-114

Michael Wilson (Cardinals)

Over 56.5

-114

Under 56.5

-114

Malik Nabers (Giants)

Over 54.5

-114

Under 54.5

-114

Isaiah Likely (Giants)

Over 41.5

-114

Under 41.5

-114

Marvin Harrison Jr. (Cardinals)

Over 34.5

-114

Under 34.5

-114

Malachi Fields (Giants)

Over 23.5

-114

Under 23.5

-114

Darnell Mooney (Giants)

Over 20.5

-114

Under 20.5

-114

Kendrick Bourne (Cardinals)

Over 19.5

-114

Under 19.5

-114

Cam Skattebo (Giants)

Over 18.5

-114

Under 18.5

-114

Jeremiyah Love (Cardinals)

Over 16.5

-114

Under 16.5

-114

Theo Johnson (Giants)

Over 8.5

-114

Under 8.5

-114

Elijah Higgins (Cardinals)

Over 4.5

-114

Under 4.5

-114

Rushing Yards

Jeremiyah Love (Cardinals)

Over 66.5

-114

Under 66.5

-114

Cam Skattebo (Giants)

Over 62.5

-114

Under 62.5

-114

Najee Harris (Giants)

Over 23.5

-114

Under 23.5

-114

Tyler Allgeier (Cardinals)

Over 22.5

-114

Under 22.5

-114

Jacoby Brissett (Cardinals)

Over 7.5

-114

Under 7.5

-114

Jameis Winston (Giants)

Over 5.5

-114

Under 5.5

-114

Passing Yards

Jacoby Brissett (Cardinals)

Over 230.5

-114

Under 230.5

-114

Jameis Winston (Giants)

Over 208.5

-114

Under 208.5

-114

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Can Giants Keep Their Home Form Going?

The Giants have put together three consecutive victories at MetLife Stadium. Big Blue has five wins and five losses in the last 10 games at home, averaging 21.60 points scored and 20.70 points allowed.

The Cards have two wins and eight losses in the last 10 games away from home, putting up 21.80 points on average and giving up 29.20.

The Cards beat the Giants 26-7 when the teams last met at MetLife Stadium.

Last 10 Games		W-L	P	PF	PA	O44.5	U44.5
Giants Home Stats		5-5	42.30	21.60	20.70	6	4
Cardinals Away Stats		2-8	51.00	21.80	29.20	6	4

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O44.5 = Games Over 44.5 Points
• U44.5 = Games Under 44.5 Points

Latest regular season and playoff games stats.

Arizona Cardinals Stats

New York Giants Stats

Moneyline

• 1 win and 9 defeats in the last 10 games
• 2 wins and 8 defeats in the last 10 games on the road

Moneyline

• 4 wins and 6 defeats in the last 10 games
• 5 wins and 5 defeats in the last 10 home games

Point Spread

• -2.5 Betting Line: Have covered the spread in 1 of the last 10 games
• -2.5 Betting Line on the Road: Have covered the spread in 2 of the last 10 games on the road

Point Spread

• +2.5 Betting Line: Have covered the spread in 4 of the last 10 games
• +2.5 Betting Line at Home: Have covered the spread in 5 of the last 10 home games

Total Points

• Game Totals: An average of 50.70 pts in the previous 10 games
• Game Totals on the Road: An average of 51.00 pts in the previous 10 games on the road
• Over 44.5: Covered in 7 of the previous 10 games
• Over 44.5 on the Road: Covered in 6 of the previous 10 games on the road
• Team Totals: Have scored an average of 19.40 pts and allowed 31.30 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 21.80 pts and allowed 29.20 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 43.10 pts in the previous 10 games
• Game Totals at Home: An average of 42.30 pts in the previous 10 home games
• Over 44.5: Covered in 6 of the previous 10 games
• Over 44.5 at Home: Covered in 6 of the previous 10 home games
• Team Totals: Have scored an average of 21.00 pts and allowed 22.10 pts in the last 10 games
• Team Totals at Home: Have scored an average of 21.60 pts and allowed 20.70 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 311.20 Yds. Allowed 383.10 Yds
• Rushing Yards: Gained 80.50 Yds. Allowed 141.90 Yds
• Passing Yards: Gained 230.70 Yds. Allowed 241.20 Yds
• Total Touchdowns: Scored 2.10 TD. Allowed 3.80 TD
• Rushing Touchdowns: Scored 0.10 TD. Allowed 0.90 TD
• Passing Touchdowns: Scored 1.30 TD. Allowed 1.80 TD
• Total 1st Downs: Picked up 19.10. Allowed 22.50
• Total Turnovers: Committed 0.90. Committed by opponents 1.00
• Total Penalties: Committed 6.10. Committed by opponents 5.20
• Penalty Yards: Lost 51.70 Yds. Gained 40.70 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 315.40 Yds. Allowed 326.90 Yds
• Rushing Yards: Gained 132.00 Yds. Allowed 126.20 Yds
• Passing Yards: Gained 183.40 Yds. Allowed 200.70 Yds
• Total Touchdowns: Scored 2.30 TD. Allowed 2.60 TD
• Rushing Touchdowns: Scored 0.90 TD. Allowed 0.70 TD
• Passing Touchdowns: Scored 0.80 TD. Allowed 0.90 TD
• Total 1st Downs: Picked up 19.80. Allowed 19.20
• Total Turnovers: Committed 0.90. Committed by opponents 1.40
• Total Penalties: Committed 7.20. Committed by opponents 7.50
• Penalty Yards: Lost 64.50 Yds. Gained 65.40 Yds

Last 10 Games on the Road

• Total Yards: Gained 333.60 Yds. Allowed 362.20 Yds
• Rushing Yards: Gained 93.90 Yds. Allowed 126.60 Yds
• Passing Yards: Gained 239.70 Yds. Allowed 235.60 Yds
• Total Touchdowns: Scored 2.40 TD. Allowed 3.40 TD
• Rushing Touchdowns: Scored 0.30 TD. Allowed 0.90 TD
• Passing Touchdowns: Scored 1.60 TD. Allowed 1.50 TD
• Total 1st Downs: Picked up 20.80. Allowed 21.80
• Total Turnovers: Committed 0.90. Committed by opponents 1.10
• Total Penalties: Committed 5.50. Committed by opponents 5.20
• Penalty Yards: Lost 50.20 Yds. Gained 45.50 Yds

Last 10 Home Games

• Total Yards: Gained 306.80 Yds. Allowed 303.10 Yds
• Rushing Yards: Gained 146.20 Yds. Allowed 116.90 Yds
• Passing Yards: Gained 160.60 Yds. Allowed 186.20 Yds
• Total Touchdowns: Scored 2.50 TD. Allowed 2.40 TD
• Rushing Touchdowns: Scored 1.20 TD. Allowed 1.00 TD
• Passing Touchdowns: Scored 0.80 TD. Allowed 0.90 TD
• Total 1st Downs: Picked up 20.90. Allowed 19.50
• Total Turnovers: Committed 0.80. Committed by opponents 1.40
• Total Penalties: Committed 7.60. Committed by opponents 8.40
• Penalty Yards: Lost 60.90 Yds. Gained 72.40 Yds

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