Lions vs Cardinals Prediction, Picks & Odds | 11 Oct 2026

Lions vs Cardinals Predictions

Best Bet

Under 54.5 Points @ -112

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Play the Unders at -112 when the Cardinals and the Lions take to the field. The 54.5 points line looks plenty big enough and we’re not sure the pair will combine to get this total.

Get our Lions vs Cardinals betting picks, including our Best Bet, Player Props, Same Game Parlay and Correct Score Prediction. Explore the full analysis behind each wager further down the page.

Lions vs Cardinals Preview

The Detroit Lions battle the Arizona Cardinals at State Farm Stadium, with kickoff scheduled for 16:25 on Sunday, October 11.

Detroit Lions have now lost back-to-back road games. In their previous game, Carolina Panthers won 32-26 at Bank of America Stadium. The Lions recorded 452 yards, breaking down to 406 passing and 46 rushing yards. The offense produced 24 first downs and scored two touchdowns.

Arizona Cardinals lost on the road in their last game, making it three straight defeats. New York Giants won 36-24 at MetLife Stadium. The Cardinals moved the ball for 270 yards, breaking down to 147 passing and 123 rushing yards. They picked up 19 first downs to go with 3 trips to the end zone.

H2H: 20-13 Win for Lions in Last H2H Clash

The Lions triumphed 20-13 when they last played the Cards. This head-to-head was played at State Farm Stadium. Looking at the past 4 H2H clashes, there has been one draw. The Lions have won three games and the Cards zero.

Quarterbacks

Jared Goff

280.5 Passing Yards

Over -114

Under -114

Jacoby Brissett

266.5 Passing Yards

Over -114

Under -114

Best Bet

In our opinion, the teams are unlikely to reach the 54.5 points line. Therefore, chance an Under bet at -112 and hope the number isn’t reached in this NFL matchup.

Key stats supporting our main match prediction:

• The 54.5 line hasn’t been covered in 15 of the last 20 Cardinals games at home.
• The 54.5 line hasn’t been covered in 7 of the last 10 Cardinals games at home.
• The 54.5 line hasn’t been covered in the last 2 Cardinals games at home.
• The 54.5 line hasn’t been covered in the last 4 games between these teams.

Our NFL picks are always well-researched, starting with a combination of the latest team news and current form. Once we’ve got a solid read on the matchup, we layer in the key data to back it up.

Under 54.5 Probability

The best betting apps make it a 52.9% chance that our pick is settled as a winner. After careful examination, our analysts have this probability close to 60%. This is why we regard this as a value bet.

We recommend moving the line if you want more juice from your Total wager. If you’re going Under, then consider a slightly riskier bet which has a bigger payout.

Our quick-access guide helps you unlock the best betting offers, generous promos, and the freshest free bets today.

Under 54.5 Points @ -112 Bet Now

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Player Prop Picks

Top Pick: Jared Goff Under 280.5 Passing Yards -114

The odds for Jared Goff (Lions) to finish with fewer than 280.5 passing yards stand at -114. The line looks too high and we’re confident he’ll fall short of the QB Passing Yards total.

Latest Jared Goff Player Prop Odds

Passing Yards

Over 280.5

-114

Under 280.5

-114

Rushing Yards

Over 0.5

-114

Under 0.5

-114

---

Tyler Allgeier Under 27.5 Rushing Yards -114

The odds for Tyler Allgeier (Cards) to record fewer than 27.5 rushing yards stand at -114. We're confident he’ll fall short of the Player Rushing Yards line, so we're backing the Under.

Latest Tyler Allgeier Player Prop Odds

Receiving Yards

Over 9.5

-114

Under 9.5

-114

Rushing Yards

Over 27.5

-114

Under 27.5

-114

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Lions 30 - 20 Cardinals

We’re going for the Lions to win by a 30-20 scoreline, something which is available at huge odds. This speculative wager can provide a big return for a small stake.

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Lions vs Cardinals Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

Detroit Lions are regarded as having a 71% chance of winning this game according to the latest betting odds. The sportsbooks have priced them up at -244. For those wanting to back Arizona Cardinals, you will find +198 about the underdogs.

The spread is currently 5.5, with the total points line at 54.5. NFL bettors love the chance to get an alternative angle by going for a Total wager. Those expecting a low total can back Under 54.5 at -112.

There’s no shortage of betting opportunities when it comes to the National Football League. The top sportsbooks offer a wide variety of game lines and team props for each matchup, so be sure to explore both the pre-game and in-game markets before making your pick.

Moneyline

Lions

-244

Cardinals

+198

Point Spread

Lions -5.5

-105

Cardinals +5.5

-115

Total Points

Under 54.5

-112

Over 54.5

-108

Receiving Yards

Trey McBride (Cardinals)

Over 81.5

-114

Under 81.5

-114

Amon-Ra St. Brown (Lions)

Over 78.5

-114

Under 78.5

-114

Michael Wilson (Cardinals)

Over 74.5

-114

Under 74.5

-114

Sam LaPorta (Lions)

Over 51.5

-114

Under 51.5

-114

Jameson Williams (Lions)

Over 51.5

-114

Under 51.5

-114

Jahmyr Gibbs (Lions)

Over 37.5

-114

Under 37.5

-114

Marvin Harrison Jr. (Cardinals)

Over 34.5

-114

Under 34.5

-114

Isaac TeSlaa (Lions)

Over 25.5

-114

Under 25.5

-114

Kendrick Bourne (Cardinals)

Over 23.5

-114

Under 23.5

-114

Jeremiyah Love (Cardinals)

Over 11.5

-114

Under 11.5

-114

Tyler Allgeier (Cardinals)

Over 9.5

-114

Under 9.5

-114

Rushing Yards

Jahmyr Gibbs (Lions)

Over 90.5

-114

Under 90.5

-114

Jeremiyah Love (Cardinals)

Over 46.5

-114

Under 46.5

-114

Tyler Allgeier (Cardinals)

Over 27.5

-114

Under 27.5

-114

Jacoby Brissett (Cardinals)

Over 8.5

-114

Under 8.5

-114

Sione Vaki (Lions)

Over 8.5

-114

Under 8.5

-114

Jared Goff (Lions)

Over 0.5

-114

Under 0.5

-114

Passing Yards

Jared Goff (Lions)

Over 280.5

-114

Under 280.5

-114

Jacoby Brissett (Cardinals)

Over 266.5

-114

Under 266.5

-114

Cards Currently at Eight Home Losses in a Row

The Cardinals have been handed eight consecutive losses at State Farm Stadium. They have gone 2-8 across their last 10 home games, putting up 22.70 points per contest and giving up 28.80.

The Lions have gone 4-6 across their last 10 road games, posting 26.50 points per contest while yielding 27.50.

The Lions beat the Cards 20-13 when they last met at State Farm Stadium.

Last 10 Games		W-L	P	PF	PA	O54.5	U54.5
Cardinals Home Stats		2-8	51.50	22.70	28.80	3	7
Lions Away Stats		4-6	54.00	26.50	27.50	6	4

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O54.5 = Games Over 54.5 Points
• U54.5 = Games Under 54.5 Points

Latest regular season and playoff games stats.

Detroit Lions Stats

Arizona Cardinals Stats

Moneyline

• 4 wins and 6 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 games on the road

Moneyline

• 1 win and 9 defeats in the last 10 games
• 2 wins and 8 defeats in the last 10 home games

Point Spread

• -5.5 Betting Line: Have covered the spread in 2 of the last 10 games
• -5.5 Betting Line on the Road: Have covered the spread in 3 of the last 10 games on the road

Point Spread

• +5.5 Betting Line: Have covered the spread in 2 of the last 10 games
• +5.5 Betting Line at Home: Have covered the spread in 6 of the last 10 home games

Total Points

• Game Totals: An average of 57.10 pts in the previous 10 games
• Game Totals on the Road: An average of 54.00 pts in the previous 10 games on the road
• Over 54.5: Covered in 7 of the previous 10 games
• Over 54.5 on the Road: Covered in 6 of the previous 10 games on the road
• Team Totals: Have scored an average of 27.40 pts and allowed 29.70 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 26.50 pts and allowed 27.50 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 51.60 pts in the previous 10 games
• Game Totals at Home: An average of 51.50 pts in the previous 10 home games
• Over 54.5: Covered in 5 of the previous 10 games
• Over 54.5 at Home: Covered in 3 of the previous 10 home games
• Team Totals: Have scored an average of 19.40 pts and allowed 32.20 pts in the last 10 games
• Team Totals at Home: Have scored an average of 22.70 pts and allowed 28.80 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 373.80 Yds. Allowed 390.20 Yds
• Rushing Yards: Gained 91.10 Yds. Allowed 130.70 Yds
• Passing Yards: Gained 282.70 Yds. Allowed 259.50 Yds
• Total Touchdowns: Scored 3.00 TD. Allowed 3.40 TD
• Rushing Touchdowns: Scored 0.50 TD. Allowed 0.80 TD
• Passing Touchdowns: Scored 1.20 TD. Allowed 1.00 TD
• Total 1st Downs: Picked up 22.40. Allowed 23.60
• Total Turnovers: Committed 0.80. Committed by opponents 1.00
• Total Penalties: Committed 6.60. Committed by opponents 5.00
• Penalty Yards: Lost 42.40 Yds. Gained 42.70 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 305.60 Yds. Allowed 377.90 Yds
• Rushing Yards: Gained 87.30 Yds. Allowed 137.20 Yds
• Passing Yards: Gained 218.30 Yds. Allowed 240.70 Yds
• Total Touchdowns: Scored 2.10 TD. Allowed 3.90 TD
• Rushing Touchdowns: Scored 0.00 TD. Allowed 0.90 TD
• Passing Touchdowns: Scored 1.20 TD. Allowed 1.50 TD
• Total 1st Downs: Picked up 18.50. Allowed 22.40
• Total Turnovers: Committed 1.20. Committed by opponents 0.90
• Total Penalties: Committed 6.10. Committed by opponents 5.10
• Penalty Yards: Lost 51.90 Yds. Gained 39.10 Yds

Last 10 Games on the Road

• Total Yards: Gained 381.80 Yds. Allowed 339.60 Yds
• Rushing Yards: Gained 111.20 Yds. Allowed 123.50 Yds
• Passing Yards: Gained 270.60 Yds. Allowed 216.10 Yds
• Total Touchdowns: Scored 3.00 TD. Allowed 3.40 TD
• Rushing Touchdowns: Scored 0.70 TD. Allowed 0.90 TD
• Passing Touchdowns: Scored 1.60 TD. Allowed 1.50 TD
• Total 1st Downs: Picked up 21.90. Allowed 21.70
• Total Turnovers: Committed 0.90. Committed by opponents 0.60
• Total Penalties: Committed 6.20. Committed by opponents 4.80
• Penalty Yards: Lost 42.10 Yds. Gained 33.80 Yds

Last 10 Home Games

• Total Yards: Gained 322.80 Yds. Allowed 366.60 Yds
• Rushing Yards: Gained 92.80 Yds. Allowed 130.60 Yds
• Passing Yards: Gained 230.00 Yds. Allowed 236.00 Yds
• Total Touchdowns: Scored 2.60 TD. Allowed 3.40 TD
• Rushing Touchdowns: Scored 0.80 TD. Allowed 1.10 TD
• Passing Touchdowns: Scored 1.50 TD. Allowed 1.80 TD
• Total 1st Downs: Picked up 19.10. Allowed 23.00
• Total Turnovers: Committed 1.30. Committed by opponents 1.50
• Total Penalties: Committed 7.60. Committed by opponents 6.20
• Penalty Yards: Lost 53.60 Yds. Gained 52.20 Yds

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