Broncos vs 49ers Prediction, Picks & Odds | 04 Oct 2026

Broncos vs 49ers Predictions

Best Bet

49ers -2.5 @ -120

Bet Now T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

The Niners are available at odds of -120 when it comes to backing them against the spread. The -2.5 line could be covered with ease against the Broncos and this looks like a value bet.

Discover our expert Broncos vs Niners predictions, featuring our Best Bet, Player Props, Same Game Parlay and Correct Score Pick. Dive into each section for the full analysis of each play.

Broncos vs 49ers Preview

The Denver Broncos go up against the San Francisco 49ers in a Week 4 matchup at Levi's Stadium, with kickoff scheduled for 16:25 on Sunday, October 4.

Denver faces a major road test against San Francisco in a matchup between teams carrying legitimate expectations of playing deep into January. Brock Purdy and Bo Nix give the game an appealing quarterback dimension, while Kyle Shanahan and Sean Payton bring two of the NFL’s most accomplished offensive minds to a high-profile late-afternoon showdown.

The Denver Broncos are 2-1 after making it back-to-back wins with a 30-26 home victory over the Los Angeles Rams at Empower Field at Mile High. Denver finished with 257 total yards, including 179 passing and 78 rushing, while recording 20 first downs and scoring four touchdowns.

Bo Nix completed 17 of 34 passes for 186 yards, two touchdowns and one interception, while also adding a rushing touchdown. J.K. Dobbins led the Broncos on the ground with 17 carries for 49 yards, while Courtland Sutton caught three passes for 46 yards.

The San Francisco 49ers are 3-0 after extending their winning run with a 36-30 home victory over the Arizona Cardinals at Levi's Stadium. San Francisco piled up 437 total yards, including 297 passing and 140 rushing, while recording 23 first downs and scoring five touchdowns.

Brock Purdy completed 15 of 27 passes for 297 yards and four touchdowns without an interception. Christian McCaffrey rushed 15 times for 75 yards and a touchdown while adding four catches for 41 yards, while Deebo Samuel Sr. provided the biggest play through the air with an 80-yard touchdown reception.

H2H: Broncos Won the Last Meeting

The Broncos came out on top when these teams last met in September 2022, earning an 11-10 home victory over the Niners at Empower Field at Mile High.

Quarterbacks

Bo Nix

221.5 Passing Yards

Over -114

Under -114

Brock Purdy

233.5 Passing Yards

Over -114

Under -114

Best Bet

San Francisco really stand out in this NFL matchup. Back the Niners against the spread with the confidence that they can cover a generous -2.5 line at -120.

Key stats supporting our main match prediction:

• The -2.5 line has been covered by 49ers in 8 of their last 10 games.
• The -2.5 line has been covered by 49ers in 4 of their last 5 games.
• The -2.5 line has been covered by 49ers in 3 consecutive games.

Injuries are always factored in by the NFL handicappers at Sportsgambler.com. Our picks are also shaped by recent form, with up-to-date stats playing a key role before any selections are locked in.

Niners -2.5 Probability

If you go by the best betting sites, our pick has a 54.6% chance of winning. Taking all factors into consideration, our cappers think there’s a stronger chance of success and estimate the probability to be closer to 60%. The bet can be recommended for this precise reason.

There are lots of betting alternatives to the spread and we particularly like the Winning Margin lines. It’s great whether you’re expecting things to be close or comprehensive.

Make your bet go further. Browse our updated guide packed with the best free bets, sign-up offers and betting bonuses.

49ers -2.5 @ -120 Bet Now

BetMGM Promo Up To $1500 in Bonus Bets Get Bonus T&C apply. Gamble responsibly 18+

Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Oct 2, 22:25). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: George Kittle Anytime TD +155

George Kittle (Niners) is available at +155 to score a TD. There are appealing odds on offer for this Anytime Touchdown Scorer pick, and we believe it's an attractive wager for him to punch it in.

Latest George Kittle Player Prop Odds

Touchdown

Anytime

+155

First

+1000

Receiving Yards

Over 62.5

-114

Under 62.5

-114

---

Brock Purdy Over 229.5 Passing Yards -114

Brock Purdy (Niners) can be backed at -114 to reach over 229.5 passing yards. We’re happy to take him to cover the QB Passing Yards line and bettors can place this wager with confidence.

Latest Brock Purdy Player Prop Odds

Touchdown

Anytime

+360

First

+1900

Passing Yards

Over 233.5

-114

Under 233.5

-114

Rushing Yards

Over 17.5

-114

Under 17.5

-114

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Broncos 17 - 28 49ers

There are stacks of correct score lines on offer and we’re looking at the Niners to achieve a winning scoreline of 28-17 where a huge potential return is on the cards.

T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Broncos vs 49ers Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

For this game, the sportsbooks’ Moneyline betting odds mean San Francisco 49ers are -152 favorites to win and that means a 60% chance of landing a victory. The market suggests that Denver Broncos are least likely to win at +128.

The spread is calculated to be 2.5, while total points comes in at 48.5. NFL bettors love the chance to get an alternative angle by going for a Total wager. There’s the chance to back Under 48.5 at -118.

The top NFL sportsbooks offer a huge selection of game lines and team props when it comes to this popular league. Make sure you look through all the available options before deciding which bet to place.

Moneyline

Broncos

+128

49ers

-152

Point Spread

Broncos +2.5

-100

49ers -2.5

-122

Total Points

Under 48.5

-118

Over 48.5

-104

Favorite Christian McCaffrey is now available at +400 to be the First Touchdown Scorer. You will find similar odds apply when it comes to him scoring the last TD.

Touchdown

Christian McCaffrey (49ers)

First TD

+400

Anytime TD

-175

J.K. Dobbins (Broncos)

First TD

+700

Anytime TD

+135

George Kittle (49ers)

First TD

+1000

Anytime TD

+155

Mike Evans (49ers)

First TD

+1000

Anytime TD

+195

Deebo Samuel (49ers)

First TD

+1100

Anytime TD

+185

Jaylen Waddle (Broncos)

First TD

+1300

Anytime TD

+200

Courtland Sutton (Broncos)

First TD

+1400

Anytime TD

+210

RJ Harvey (Broncos)

First TD

+1400

Anytime TD

+230

Brock Purdy (49ers)

First TD

+1900

Anytime TD

+360

Kaelon Black (49ers)

First TD

+1900

Anytime TD

+370

Pat Bryant (Broncos)

First TD

+2000

Anytime TD

+350

Bo Nix (Broncos)

First TD

+2200

Anytime TD

+410

Evan Engram (Broncos)

First TD

+2500

Anytime TD

+470

Brandin Cooks (49ers)

First TD

+3000

Anytime TD

+600

KhaDarel Hodge (49ers)

First TD

+3500

Anytime TD

+750

Jacob Cowing (49ers)

First TD

+4500

Anytime TD

+950

Jordan Watkins (49ers)

First TD

+4500

Anytime TD

+950

Lil'Jordan Humphrey (Broncos)

First TD

+4500

Anytime TD

+950

Troy Franklin (Broncos)

First TD

+4500

Anytime TD

+950

Adam Trautman (Broncos)

First TD

+4500

Anytime TD

+850

Kyle Juszczyk (49ers)

First TD

+4500

Anytime TD

+850

Marvin Mims Jr. (Broncos)

First TD

+5000

Anytime TD

+1000

Dallen Bentley (Broncos)

First TD

+5000

Anytime TD

+1100

Tyler Badie (Broncos)

First TD

+5000

Anytime TD

+1100

Nate Adkins (Broncos)

First TD

+5000

Anytime TD

+1100

Malik Turner (49ers)

First TD

+6000

Anytime TD

+1100

Luke Farrell (49ers)

First TD

+8000

Anytime TD

+1500

Brayden Willis (49ers)

First TD

+8000

Anytime TD

+2000

Adam Prentice (Broncos)

First TD

+8000

Anytime TD

+2000

James Jordan (49ers)

First TD

+10000

Anytime TD

+3000

Receiving Yards

George Kittle (49ers)

Over 62.5

-114

Under 62.5

-114

Jaylen Waddle (Broncos)

Over 56.5

-114

Under 56.5

-114

Mike Evans (49ers)

Over 44.5

-114

Under 44.5

-114

Christian McCaffrey (49ers)

Over 41.5

-114

Under 41.5

-114

Courtland Sutton (Broncos)

Over 38.5

-114

Under 38.5

-114

Deebo Samuel (49ers)

Over 34.5

-114

Under 34.5

-114

Pat Bryant (Broncos)

Over 22.5

-114

Under 22.5

-114

RJ Harvey (Broncos)

Over 21.5

-114

Under 21.5

-114

Evan Engram (Broncos)

Over 17.5

-114

Under 17.5

-114

Kyle Juszczyk (49ers)

Over 8.5

-114

Under 8.5

-114

Troy Franklin (Broncos)

Over 5.5

-114

Under 5.5

-114

Adam Trautman (Broncos)

Over 4.5

-114

Under 4.5

-114

Rushing Yards

Christian McCaffrey (49ers)

Over 65.5

-114

Under 65.5

-114

J.K. Dobbins (Broncos)

Over 58.5

-114

Under 58.5

-114

Kaelon Black (49ers)

Over 20.5

-114

Under 20.5

-114

Brock Purdy (49ers)

Over 17.5

-114

Under 17.5

-114

Bo Nix (Broncos)

Over 16.5

-114

Under 16.5

-114

RJ Harvey (Broncos)

Over 15.5

-114

Under 15.5

-114

Passing Yards

Brock Purdy (49ers)

Over 233.5

-114

Under 233.5

-114

Bo Nix (Broncos)

Over 221.5

-114

Under 221.5

-114

For those looking to enjoy a thrilling in-game wager, then NFL micro betting could be up your street. You are now able to wager on what will happen on the next snap by staking your money on the Next Play Result.

Niners Hold Seven Wins in Previous Ten at Home

The Niners have seven wins and three losses in the last 10 games at home, putting up 25.60 points on average and giving up 22.00.

The Broncos have six wins and four losses in the last 10 games on the road, averaging 18.80 points on offense and surrendering 21.30 on defense.

The previous meeting at Levi's Stadium saw the Broncos defeat the Niners 30-9.

Last 10 Games		W-L	P	PF	PA	O47.5	U47.5
49ers Home Stats		7-3	47.60	25.60	22.00	5	5
Broncos Away Stats		6-4	40.10	18.80	21.30	2	8

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O47.5 = Games Over 47.5 Points
• U47.5 = Games Under 47.5 Points

Latest regular season and playoff games stats.

Denver Broncos Stats

San Francisco 49ers Stats

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 6 wins and 4 defeats in the last 10 games on the road

Moneyline

• 8 wins and 2 defeats in the last 10 games
• 7 wins and 3 defeats in the last 10 home games

Point Spread

• +2.5 Betting Line: Have covered the spread in 7 of the last 10 games
• +2.5 Betting Line on the Road: Have covered the spread in 7 of the last 10 games on the road

Point Spread

• -2.5 Betting Line: Have covered the spread in 8 of the last 10 games
• -2.5 Betting Line at Home: Have covered the spread in 6 of the last 10 home games

Total Points

• Game Totals: An average of 42.00 pts in the previous 10 games
• Game Totals on the Road: An average of 40.10 pts in the previous 10 games on the road
• Over 47.5: Covered in 4 of the previous 10 games
• Over 47.5 on the Road: Covered in 2 of the previous 10 games on the road
• Team Totals: Have scored an average of 21.70 pts and allowed 20.30 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 18.80 pts and allowed 21.30 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 50.30 pts in the previous 10 games
• Game Totals at Home: An average of 47.60 pts in the previous 10 home games
• Over 47.5: Covered in 5 of the previous 10 games
• Over 47.5 at Home: Covered in 5 of the previous 10 home games
• Team Totals: Have scored an average of 28.30 pts and allowed 22.00 pts in the last 10 games
• Team Totals at Home: Have scored an average of 25.60 pts and allowed 22.00 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 309.00 Yds. Allowed 309.00 Yds
• Rushing Yards: Gained 97.80 Yds. Allowed 118.60 Yds
• Passing Yards: Gained 211.20 Yds. Allowed 190.40 Yds
• Total Touchdowns: Scored 2.40 TD. Allowed 2.00 TD
• Rushing Touchdowns: Scored 0.50 TD. Allowed 0.20 TD
• Passing Touchdowns: Scored 0.90 TD. Allowed 1.00 TD
• Total 1st Downs: Picked up 18.80. Allowed 18.60
• Total Turnovers: Committed 1.10. Committed by opponents 1.30
• Total Penalties: Committed 5.30. Committed by opponents 5.20
• Penalty Yards: Lost 40.10 Yds. Gained 41.60 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 358.00 Yds. Allowed 319.90 Yds
• Rushing Yards: Gained 121.30 Yds. Allowed 125.40 Yds
• Passing Yards: Gained 236.70 Yds. Allowed 194.50 Yds
• Total Touchdowns: Scored 3.50 TD. Allowed 2.50 TD
• Rushing Touchdowns: Scored 0.60 TD. Allowed 0.90 TD
• Passing Touchdowns: Scored 1.50 TD. Allowed 0.90 TD
• Total 1st Downs: Picked up 21.90. Allowed 19.40
• Total Turnovers: Committed 1.10. Committed by opponents 0.60
• Total Penalties: Committed 3.90. Committed by opponents 5.90
• Penalty Yards: Lost 38.20 Yds. Gained 42.30 Yds

Last 10 Games on the Road

• Total Yards: Gained 292.50 Yds. Allowed 315.10 Yds
• Rushing Yards: Gained 105.10 Yds. Allowed 118.20 Yds
• Passing Yards: Gained 187.40 Yds. Allowed 196.90 Yds
• Total Touchdowns: Scored 2.10 TD. Allowed 1.90 TD
• Rushing Touchdowns: Scored 0.80 TD. Allowed 0.40 TD
• Passing Touchdowns: Scored 1.10 TD. Allowed 1.10 TD
• Total 1st Downs: Picked up 17.60. Allowed 19.50
• Total Turnovers: Committed 0.80. Committed by opponents 0.40
• Total Penalties: Committed 6.80. Committed by opponents 5.30
• Penalty Yards: Lost 59.10 Yds. Gained 36.70 Yds

Last 10 Home Games

• Total Yards: Gained 371.90 Yds. Allowed 326.40 Yds
• Rushing Yards: Gained 117.70 Yds. Allowed 113.50 Yds
• Passing Yards: Gained 254.20 Yds. Allowed 212.90 Yds
• Total Touchdowns: Scored 3.10 TD. Allowed 2.50 TD
• Rushing Touchdowns: Scored 0.80 TD. Allowed 0.70 TD
• Passing Touchdowns: Scored 1.30 TD. Allowed 1.20 TD
• Total 1st Downs: Picked up 22.60. Allowed 20.30
• Total Turnovers: Committed 1.50. Committed by opponents 0.30
• Total Penalties: Committed 5.00. Committed by opponents 6.40
• Penalty Yards: Lost 46.20 Yds. Gained 45.00 Yds

Where to Bet on American Football Games

Top American Football Pages